Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"GABAergic Neurons"”.
-
Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… of inhibitory versus excitatory (E/I balance) neurons. The combination of basic helix-loop-helix (bHLH) and homeodomain (HD) transcription factors is essential to generate the E/I balance required for correct functioning of neural networks. During dorsal spinal cord development, the bHLH factor …
-
The Role of PTF1A in Spinal Cord Development
… We show that PTF1a is present in precursors to GABAergic neurons in both the cerebellum and the spinal cord dorsal horn. A null mutation in Ptf1a reveals its requirement for the dorsal horn GABAergic neurons. Specifically, PTF1a is required for the generation of early born (dI4, E10.5) and late …
-
The JBS-associated E3 Ligase UBR-1 Maintains Synaptic Glutamate Homeostasis and Regulates Neurotransmitter Balance
… role of UBR-1-mediated glutamate homeostasis in GABAergic neurons. A simple GABAergic motor circuit controls C. elegans defecation. ubr-1 mutants exhibit defecation defects, coinciding with reduced activity of the GABAergic motor neurons, as well as reduced GABA signaling. I show that the reduced …
-
Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… transducing proteins at postsynaptic sites. Neurons were treated with latrunculin A to depolymerize actin, vincristine to depolymerize microtubules, or Triton X-100 to extract soluble proteins. Depolymerization of F-actin led to a decrease in both the number of synaptic NMDAR1 clusters and …
-
Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… neural precursor cells, and subsequently mature neurons and glia, by the introduction of the defined neural transcriptional factors SOX2 and PAX6. However, the understanding of the underlying gene changes that occur during reprogramming was limited, as gene characterisation in direct …
-
The nervous system of plant-parasitic nematodes and their behaviors
… in the number and structural properties of neurons among ten species across four clades. To further study the nervous system of plant-parasitic nematodes, I investigated how the neurotransmitter serotonin regulates their behaviors. Neurotransmitters are endogenous molecules used by neurons …
-
Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic cells in a tonic manner. Therefore, while traditional antipsychotics directly block dopamine receptors, some of the newly generated compounds are designed to modulate glutamate to normal …
-
Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
The roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult …
-
Fos induction within the ventral tegmental area following infusions of phencyclidine, MK-801, and nomifensine into the core and shell subterritories of the nucleus accumbens septi
… to inhibit a final common path: NAS intrinsic GABAergic output neurons projecting to the ventral tegmental area (VTA). Independent groups of animals were tested to determine whether infusions of PCP, MK-801, or nomifensine directly into the core or shell subterritory of the NAS would induce Fos …
-
The Role of Substance P in Opioid Induced Reward
… ventral tegmental area associated with dopamine neurons. Studies have shown that Substance P can potentiate positive reinforcement of opiates and may play a role in opioid reward. Here using in vivo microdialysis, we show that systemic morphine significantly increases SP release in the VTA, an …
-
Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… 32 Ⅰ. INTRODUCTION 34 A. Reelin expression in GABAergic neurons 34 B. Reelin structure 36 C. Reelin fragments 38 D. Reelin receptors and reelin signaling 39 E. The involvement of Reelin signaling in neuropsychiatric disorders 41 F. Astrogliosis 41 Ⅱ. MATERIALS AND METHODS 44 1. Animals 44 2. …
-
DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… uncovered cell type-specific changes, with GABAergic neurons and astrocytes showing the most pronounced age-related alterations. Investigating the role of DNA damage in HD, the thesis demonstrated that HD cells display increased sensitivity to genotoxic stress and impairments in specific DNA …
-
Anatomical and physiological properties of the superior paraolivary nucleus in the rat
… paraolivary nucleus (SPON) is a group of neurons located within the superior olivary complex, a constellation of brainstem nuclei involved in auditory processing. The major inputs to the SPON arise from the contralateral ear and SPON axons target primarily the ipsilateral inferior …
-
Inhibitory Control of Contextual Fear Memory and Memory Specificity
… inhibition in the brain is mainly achieved by GABAergic inhibitory neurons which exert their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of …
-
Studies on the mode of CRF action in the optic tectum of the African Clawed Frog, Xenopus laevis
… successfully showed interactions between CRF neurons and GABAergic neurons, which provided neuroanatomical evidence for the direct GABA regulation on CRF signaling pathway. The fourth chapter used the fluorescent Ca2+ marker to show the real-time Ca2+ concentration in response to CRF, but …
-
Investigating state-dependent pontine cholinergic activity during REM sleep and P-waves in vivo
… and laterodorsal tegmental nucleus (PPT/LDT) neurons have been implicated in the generation mechanisms of both REM sleep and P-waves. However, given that the PPT/LDT also contains glutamatergic and GABAergic neurons, and is surrounded by other sleep-wake regulating structures, the functional …
-
The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… of SVZ cell translocation. I demonstrated that neurons migrating in chains move rapidly along each other in the absence of glia, implying that chain migration is different from previously described radial migration. Using the in vitro assay I discovered two regions in the embryonic mouse ventral …
-
The neurotoxic effects of Manganese and the novel protective role of Drp1 in the autophagy pathway
… LC3 and p62, were identified in both DAergic and GABAergic neurons, indicative of impaired autophagy. These neurons exhibited normal mitochondrial morphology, corroborating results from previous chapters. No alterations in striatal TH density or microglial activation within the substantia nigra …
-
Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the …
-
Hippocampal Output to the Septum Regulates Locomotion and Exploration
… manipulated the DH pan-inhibitory interneurons (INs) and revealed that disrupting the DH inhibitory circuit is sufficient to acutely induce hyperlocomotion. Furthermore, we found that the DH-septum inhibitory pathway is critical for regulation of locomotion and exploratory behavior. …
Page 1 of 2