Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"GABAB receptors"”.
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Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk
… tools indicated the involvement of metabotropic GABAB receptors and ionotropic L-?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptors localized in the axon of stellate cells. Ca2+ imaging experiments performed with Two-photon Microscopy confirmed the role of presynaptic receptors …
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Characterization of Rimonabant effects on G protein activity
… (GPCRs) is the largest class of cell-surface receptors, and represents today the target of 40% of the drugs in the pharmaceutical market. In the absence of agonists, many GPCRs have found to exhibit spontaneous activity, which can be blocked by ligands that are referred to as inverse agonists …
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Inhibitory Control of Muscle Activity in Sleep
… is caused by glycinergic inhibition. These receptors are, however, important in the regulation of phasic muscle twitch activity. 2. GABAB receptors can modulate REM atonia but only when acting in concert with GABAA and glycine receptors. Blockade of all three receptor types results in a …
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Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… the activation of type 1 metabotropic glutamate receptors (mGluR1) and B type γ-aminobutyric acid (GABAB) receptors. Blocking one or both of these receptors with an antagonist inverts gain-up learning, while the agonist augments gain-up learning. Furthermore, we provide novel evidence that these …
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… chemistry, is also discussed. GABAA and GABAB receptors are then presented and the synthesis of neurosteroid antagonists acting at GABAA receptors is reported. The synthesis of such compounds was motivated to explore the mode of action of neurosteroids at GABA receptors. The observation …
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Genome-scale identification of cellular pathways required for cell surface recognition
… organisms. Interactions mediated by cell surface receptors can be challenging to detect in biochemical assays, because they are often highly transient, and membrane-embedded receptors are difficult to solubilise in their native conformation. The biochemical features of low-affinity extracellular …
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Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
… cells did not change. In mice lacking functional GABAB receptors there was a change in cell positions of neurons containing immunoreactive estrogen receptor (ER)α, which may be due to changes in cell movements and migration. There was no change in amount of cell positions of immunoreactive ERα …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… repertoire of GABAA receptor subunits as well as GABAB receptor subunits and potentially GABA transporters. NanoString nCounter analysis was utilised to confirm the gene expression of GABAA and GABAB receptor subunits by cerebrovascular cells in vitro, and protein expression was confirmed using …
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Gabab Regulation of Methamphetamine-Induced Associative Learning
… and memory). Accordingly, the metabotropic GABAB receptor has recently emerged as a potential therapeutic target for drug addiction. Administration of the direct acting GABAB receptor agonist baclofen has revealed positive outcomes in clinical trials; however, the side effects associated …
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Ethanol Enhancement of Two Distinct Inhibitory Pathways in the Rat Basolateral Amygdala: Implications for Anxiety and Alcoholism
… of GABA release, which could be regulated by GABAB autoreceptors. In contrast, EtOH enhancement of the lpcs pathway did not appear to involve an increase in GABA release, but did require activation of adrenergic receptors (ARs). Chapter III further examined the disparate nature of EtOH …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… brain, however it is now known that they have receptors that bind neurotransmitters released into the synapse, and in turn, can cause the release of gliotransmitters from the astrocyte (Araque, 2008; Araque et al., 1999; Parpura & Zorec, 2010; Perea et al., 2009). The most commonly released …
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Funktion und die Signalübertragung der GABAB-Rezeptoren im respiratorischem Netzwerk der Maus
GABAB-Rezeptoren gehören zu der Familie der metabotrophen Rezeptoren, welche eine langsame synaptische Übertragung im zentralen Nervensystem übermitteln. In dieser Arbeit haben wir die Funktion und die Signalübertragung der GABAB-Rezeptoren im pre-Bötzinger-Komplex untersucht. Unsere Daten stellen …