Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"GABAB receptor"”.
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Novel insights into the role of the GABAB receptor in depression and anxiety
The GABAB receptor is a functional heterodimer comprising the GABAB1 and GABAB2 subunits, with the GABAB1 subunit displaying two major isoforms, GABAB(1a) and GABAB(1b). Preclinical findings have strongly implicated the GABAB receptor in stress-related psychiatric disorders, however, the precise …
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Gabab Regulation of Methamphetamine-Induced Associative Learning
… and memory). Accordingly, the metabotropic GABAB receptor has recently emerged as a potential therapeutic target for drug addiction. Administration of the direct acting GABAB receptor agonist baclofen has revealed positive outcomes in clinical trials; however, the side effects associated …
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Male-specific mechanisms in a murine model of nociplastic pain
… by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic pain …
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Male-specific mechanisms in a murine model of nociplastic pain
… by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic pain …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… and in the human peripheral vasculature, but the receptor systems and cellular machinery underlying this regulation have not been characterised. And as yet, there have been no attempts to confirm the existence of this putative vascular GABA signalling system in the human brain. In this thesis, we …
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Genome-scale identification of cellular pathways required for cell surface recognition
… organisms. Interactions mediated by cell surface receptors can be challenging to detect in biochemical assays, because they are often highly transient, and membrane-embedded receptors are difficult to solubilise in their native conformation. The biochemical features of low-affinity extracellular …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of three major components. In the first component (Chapter 2), I developed a novel technique …
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Fluorinated Organic Molecules for Medicinal Applications
… in our lab to develop new agonists of the GABAB receptor. The value of GABAB agonists as muscle relaxants is well established, and interest in these agonists has been rekindled due to reports of new applications in managing drug and alcohol tolerance. We have developed several new …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… ionotropic glutamate receptors (AMPAR) suggesting that they were primarily PE-mediated. The effects of raised stimulus intensity (RS) and/or increased frequency (IF) activation of the molecular layer on FP responses were examined. In sagittai and transverse slices …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… brain, however it is now known that they have receptors that bind neurotransmitters released into the synapse, and in turn, can cause the release of gliotransmitters from the astrocyte (Araque, 2008; Araque et al., 1999; Parpura & Zorec, 2010; Perea et al., 2009). The most commonly released …
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The risk and severity of preeclampsia secondary to iodine deficiency and iodine deficiency-mediated subclinical hypothyroidism: mechanisms and early cardiovascular consequences
… intact. Low serum potassium further attenuates GABAB receptor mediated tonic extra-synaptic inhibition resulting in net motor neurone stimulation and increased predisposition to the involuntary tonic-clonic convulsions observed in eclampsia. Conclusion There is still a high prevalence of …
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Maturation of GABAergic signaling during brainstem development
… GABAA-Rezeptorkanäle und G-proteingekoppelte GABAB-Rezeptoren. Neue Studien haben aber gezeigt, dass während der Entwicklung GABA im frühpostnatalen ZNS auch exitatorisch wirken kann. In dieser Studie untersuchten wir Faktoren, die die entwicklungsbedingten Veränderungen des ionotropen GABAA- …
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Postnatale Entwicklung des GABAergen Systems im Gehirn der Maus
… ersten postnatalen Tagen (P0-P3) weitgehend von GABAB-Rezeptoren ausgeübt wird. Die GABAA-Rezeptor-vermittelte Inhibition spielt erst nach P4 eine funktionelle Rolle, wenn die intrazelluläre Chloridkonzentration von ca. 100 mM an P0 auf das adulte Nieveau (4-7 mM) gesunken ist. Diese funktionelle …