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Showing 1 to 20 of 30 for “"GABAB"”.

  1. Gabab Regulation of Methamphetamine-Induced Associative Learning

    Voigt, Robin Michelle2016

    … and memory). Accordingly, the metabotropic GABAB receptor has recently emerged as a potential therapeutic target for drug addiction. Administration of the direct acting GABAB receptor agonist baclofen has revealed positive outcomes in clinical trials; however, the side effects associated …

    loyola-thes Repository record

  2. Design, synthesis and pharmacological evaluation of certain GABAB agonists

    Attia, Mohamad IbrahimUniversität Würzburg

    … Die synthetisierten Verbindungen wurden als GABAB-Rezeptor Agonisten, in einem auf Ca2+-Messungen basierenden Funktional-Assay (in vitro tsA Zellen mit GABAB1b/GABAB2/Gαq-z5 transfektiert), getestet und daraus ein Struktur-Aktivitäts Modell abgeleitet. Im allgemein Teil dieser Arbeit wird ein …

    wurz-thes Repository record

  3. Funktion und die Signalübertragung der GABAB-Rezeptoren im respiratorischem Netzwerk der Maus

    Sargsyan, Vardanush2012

    GABAB-Rezeptoren gehören zu der Familie der metabotrophen Rezeptoren, welche eine langsame synaptische Übertragung im zentralen Nervensystem übermitteln. In dieser Arbeit haben wir die Funktion und die Signalübertragung der GABAB-Rezeptoren im pre-Bötzinger-Komplex untersucht. Unsere Daten stellen …

    goettingen Repository record

  4. Charakterisierung der GABAB-Rezeptor Subtypen 1 und 2 der Amerikanischen Großschabe Periplaneta americana

    Blankenburg, StefanieUniversität Potsdam

    … ihre Wirkung u. a. über die metabotropen GABAB-Rezeptoren. Bisher sind diese Rezeptoren bei Insekten nur rudimentär untersucht. Für die Amerikanische Großschabe als etablierter Modellorganismus konnte pharmakologisch eine modulatorische Rolle der GABAB-Rezeptoren bei der Bildung von …

    potsdam-diss Repository record

  5. Novel insights into the role of the GABAB receptor in depression and anxiety

    Felice, DanielaUniversity College Cork2013

    The GABAB receptor is a functional heterodimer comprising the GABAB1 and GABAB2 subunits, with the GABAB1 subunit displaying two major isoforms, GABAB(1a) and GABAB(1b). Preclinical findings have strongly implicated the GABAB receptor in stress-related psychiatric disorders, however, the precise …

    cork Repository record

  6. Maturation of GABAergic signaling during brainstem development

    Tantalaki, Evangelia2012

    … GABAA-Rezeptorkanäle und G-proteingekoppelte GABAB-Rezeptoren. Neue Studien haben aber gezeigt, dass während der Entwicklung GABA im frühpostnatalen ZNS auch exitatorisch wirken kann. In dieser Studie untersuchten wir Faktoren, die die entwicklungsbedingten Veränderungen des ionotropen GABAA- …

    goettingen Repository record

  7. Postnatale Entwicklung des GABAergen Systems im Gehirn der Maus

    Ritter, Barbara2012

    … ersten postnatalen Tagen (P0-P3) weitgehend von GABAB-Rezeptoren ausgeübt wird. Die GABAA-Rezeptor-vermittelte Inhibition spielt erst nach P4 eine funktionelle Rolle, wenn die intrazelluläre Chloridkonzentration von ca. 100 mM an P0 auf das adulte Nieveau (4-7 mM) gesunken ist. Diese funktionelle …

    goettingen Repository record

  8. Characterization of Rimonabant effects on G protein activity

    PORCU, ALESSANDRAUniversità degli Studi di Cagliari2016

    … of SR are mediated via GPCRs, in particular GABAB and dopamine D2 receptors, that share the same Gαi/o signaling pathways, or if SR acts directly on G protein subunits. For this purpose we investigated the molecular mechanisms of SR on G protein activity in native and recombinant systems by …

    cagliari Repository record

  9. Ethanol Enhancement of Two Distinct Inhibitory Pathways in the Rat Basolateral Amygdala: Implications for Anxiety and Alcoholism

    Silberman, YuvalWake Forest University2009

    … of GABA release, which could be regulated by GABAB autoreceptors. In contrast, EtOH enhancement of the lpcs pathway did not appear to involve an increase in GABA release, but did require activation of adrenergic receptors (ARs). Chapter III further examined the disparate nature of EtOH …

    wfu Repository record

  10. Pharmacological control of transient lower oesophageal sphincter relaxations / Ilmars Lidums.

    Lidums, Ilmars1999

    … were explored; anticholinergic agents and the GABAb agonist, baclofen.

    adelaide Repository record

  11. Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature

    Govindpani, KaranResearchSpace@Auckland2020

    … repertoire of GABAA receptor subunits as well as GABAB receptor subunits and potentially GABA transporters. NanoString nCounter analysis was utilised to confirm the gene expression of GABAA and GABAB receptor subunits by cerebrovascular cells in vitro, and protein expression was confirmed using …

    auckland-ms Repository record

  12. Genome-scale identification of cellular pathways required for cell surface recognition

    Sharma, SumanaUniversity of Cambridge2017

    … IGF2R as a binding partner for the R2 subunit of GABAB receptors, providing a mechanism for the internalisation and regulation of GABAB receptor signalling. The results here demonstrate that this single approach can identify the molecular nature and cell biology of surface receptors without the …

    cambridge Repository record

  13. Male-specific mechanisms in a murine model of nociplastic pain

    McDonough, Kathleen ErinThe University of Texas Medical Branch at Galveston2022

    … the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic pain state. However, this pain state in …

    utmb Repository record

  14. Male-specific mechanisms in a murine model of nociplastic pain

    McDonough, Kathleen ErinThe University of Texas Medical Branch at Galveston2022

    … the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic pain state. However, this pain state in …

    utmb Repository record

  15. Fluorinated Organic Molecules for Medicinal Applications

    Sowaileh, Munia2020

    … in our lab to develop new agonists of the GABAB receptor. The value of GABAB agonists as muscle relaxants is well established, and interest in these agonists has been rekindled due to reports of new applications in managing drug and alcohol tolerance. We have developed several new …

    mississippi Repository record

  16. Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development

    McClellan, Kristy Michelle, author, Tobet, Stuart A., advisorColorado State University. Libraries2008

    … cells did not change. In mice lacking functional GABAB receptors there was a change in cell positions of neurons containing immunoreactive estrogen receptor (ER)α, which may be due to changes in cell movements and migration. There was no change in amount of cell positions of immunoreactive ERα …

    colostate Repository record

  17. Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk

    Astori, SimoneUniversität Heidelberg

    … tools indicated the involvement of metabotropic GABAB receptors and ionotropic L-?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptors localized in the axon of stellate cells. Ca2+ imaging experiments performed with Two-photon Microscopy confirmed the role of presynaptic receptors …

    heid-diss Repository record

  18. Neurophysiologische Charakterisierung der wasserlöslichen Fraktion eines Johanniskrautextraktes und dessen Einfluß auf die Langzeitpotenzierung

    Heinen, Marianne

    … mit einer Schwellenwertkonzentration des GABAB-Rezeptor-Antagonisten Phaclofen bewirkte hingegen eine signifikante Verstärkung. Dieser Effekt konnte durch den AMPA-Rezeptor-Antagonisten CNQX komplett inhibiert werden. <br>Daraus läßt sich folgern, daß die Exzitation durch eine agonistische …

    freiburg-diss Repository record

  19. The Effects of Chronic Ethanol on GABA Receptors in the Nonhuman Primate Brain

    Dolson, EugeniaWake Forest University2011

    … subunits after chronic ethanol, and changes in GABAB gene and protein levels. However, human studies are somewhat scarce, and existing data is often conflicting. In a translational approach, we utilized a nonhuman primate model of chronic ethanol self-administration to investigate total GABAA, …

    wfu Repository record

  20. Inhibitory Control of Muscle Activity in Sleep

    Brooks, Patricia2011

    … regulation of phasic muscle twitch activity. 2. GABAB receptors can modulate REM atonia but only when acting in concert with GABAA and glycine receptors. Blockade of all three receptor types results in a partial reversal of REM atonia, suggesting a functional interaction is occurring between …

    toronto-retro Repository record

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