Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"GABAAR"”.
-
WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… that WWC2 negatively regulates surface GABAAR expression in the 1-month-old mouse hippocampus. Additionally, I demonstrate that the GABAAR recycling regulators HAP1 and GRIP1 are overexpressed in the membrane fraction of WWC2 KO hippocampal tissue, suggesting that WWC2 regulates GABAAR …
-
Endogenous neurosteroid actions at GABAA receptors during neuronal development
GABAA receptors (GABAARs) mediate the majority of fast inhibition in the CNS and as such are crucial to neuronal function. Two distinct modes of GABAAR mediated inhibition exist: “phasic” involves the transient activation of postsynaptic GABAARs following presynaptic vesicular GABA release and …
-
GABA-A Receptor Subunit Gene Expression as a Biomarker for Perimenstrual Change in Affect and Suicidality
… via action at the GABA-A receptor (GABAAR), and these neuroactive steroid metabolites are normal in in MCAC. The composition of GABAAR subunits within the receptor determines its activity (e.g., sensitivity to modulation and subsequent strength of inhibitory current), suggesting that …
-
Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation (α2-/-) abolishes behavioural sensitisation to cocaine. Recently, linkage association studies in humans revealed a genetic association of GABRA2 haplotypes with cocaine …
-
Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… by allosterically binding to GABAA receptors (GABAAR). Prolonged use of GABAAR positive allosteric modulators (PAM) can lead to behavioral tolerance, the diminished response to the same drug dose with repeated use, and withdrawal, a group of symptoms that occur due to abrupt end of drug …
-
The Characterization Of Pb2+ Toxicity In Rat Neural Development: An Assessment Of Pb2+ Effects On The Gaba Shift In Neural Networks And Implications For Learning And Memory Disruption
… expression regulating GAD 80, 65, CACAN â3, GABAAR and were differentially regulated cortex and hippocampus as a function of age in response to Pb2+. Brain slice immunohistochemistry revealed an early shift of KCC2 expression in both cortex and hippocampus. Notably, these alterations were …
-
Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
Numerous previous studies of GABAAR ligands have suggested that GABAAR agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7-6.0 Ã ). We have demonstrated that monomeric, homodimeric and heterodimeric non-zwitterionic GABA amides are partial, full, …
-
Study of a Transferrin Receptor Brain Shuttle for the Delivery of Nanobodies Against GABAA Receptors
… γ-aminobutyric acid type A receptors (GABAARs). Initially, anti-GABAAR Nbs were genetically fused to the BBB shuttle, 8D3, and the impact on the Nb binding properties to GABAARs was investigated. This was to establish suitable formats for CNS delivery in the future. In addition, a range …
-
Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… a potent positive modulator of GABAA receptor (GABAAR) expression and function, it has been evaluated whether neonatal estradiol treatment affects, during adulthood, GABAAR expression and function in the hippocampus, an area that exhibits the two components, tonic and phasic, of the inhibitory …
-
Mechanism of anaesthetic activation, combination and antagonism
The type A γ-aminobutyric acid receptors (GABAAR) – pentameric ligand gated ion channels (pLGICs) – are the main mediators of fast inhibitory neurotransmission in the human brain. Malfunctions in these receptors are a common cause for neurological disorders such as anxiety, epilepsy, schizophrenia …
-
Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… of action, I show that diazepam enhances GABAAR synaptic currents. Thirdly, using the in vitro 0 Mg²⁺ model of status epilepticus I show that whilst early application of diazepam has anticonvulsant properties, this is lost when the drug is applied during prolonged epileptiform activity. …
-
Design and Synthesis of Novel Benzodiazepines
… bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that relied on physiological GABA to elicit flux. We established that a tether at the N1 position of the BZD would not prevent binding to the receptor. However, coupling of GABA amides with …
-
Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… of the inhibitory synaptic proteins GABAAR and gephyrin, which has a tubulin binding motif, were unaffected by depolymerization of the cytoskeleton, or detergent extraction. These studies reveal an unsuspected heterogeneity in the modes of attachment of postsynaptic proteins to the …
-
The Octopaminergic Modulatory Circuitry of the Drosophila Larval Mushroom Body Calyx
… in. Furthermore, I found that Octα2R and GABAAR fusion proteins localised to OA cell bodies but not to neuronal terminals, suggesting that OA neurons are subjected to inhibition, again given that these are not artefacts of the fusion proteins. To obtain tools to study OA modulation in the …
-
Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All of these channels are made up of five subunits. Some pLGICs are homomeric and others are heteromeric. For example, the adult muscle-type AChR contains two α1, one β1, one δ, and one ε subunit, and each …
-
Neurosteroids: endogenous analgesics?
… involved in pain perception. GABAA receptors (GABAARs) are an important target for many clinical drugs, and certain endogenous neurosteroids act as potent allosteric modulators of these receptors. A developmental change in the rate of exponential decay of GABAergic synaptic events has been …
-
Efecto de las variaciones en los niveles de lípidos sobre el tráfico y propiedades del receptor de acetilcolina nicotínico en células CHO
… los receptores del ácido γ-amino butírico (GABAAR), el receptor de glicina (GlyR) y el subtipo 3 de los receptores de serotonina (5-HTR3). Dentro de esta superfamilia, el AChR es uno de los receptores mejor caracterizados y constituye el prototipo de los LGIC. El AChR muscular es un …