Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"GABAA receptors"”.
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
GABAA receptors (GABAARs) mediate the majority of fast inhibition in the CNS and as such are crucial to neuronal function. Two distinct modes of GABAAR mediated inhibition exist: “phasic” involves the transient activation of postsynaptic GABAARs following presynaptic vesicular GABA release and …
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Effects of Whisker-Trimming on GABAA Receptors in S1 Cortex
… with selective decreases in GABA, GAD, and GABA receptors, in deprived areas of visual and somatosensory cortex. Those studies focused on layer 4, a recipient of direct thalamocortical sensory input. However, supragranular layers 2/3 have been recently identified as a major locus of functional …
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Understanding the Structure and Function of GABAA Receptors Using Cryo-Electron Microscopy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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An electrophysiological study of the effects of resveratrol and catechin at GABAa receptors
… compounds, resveratrol and catechin modulate GABAA<sub>A</sub> receptors. To address this hypothesis, the effects of resveratrol and catechin were investigated on human recombinant GABA<sub>A</sub> receptors expressed in HEK-293 cells using electrophysiological techniques.<.p><p>HEK-293 cells …
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Study of a Transferrin Receptor Brain Shuttle for the Delivery of Nanobodies Against GABAA Receptors
… emerged to improve drug delivery by targeting receptors present at the BBB, such as transferrin receptor (TfR), hijacking endogenous trafficking systems to shuttle conjugated therapeutic cargo from the blood circulation into the brain parenchyma. Such systems could be utilised to improve the …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
Extrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, appear to be a target for the actions of alcohol (ethanol) at relatively low concentrations, perhaps suppressing the activity of GABAergic interneurons which regulate activity in the mesolimbocortical …
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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
GABAA receptor binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, …
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The Effects of Chronic Ethanol on GABA Receptors in the Nonhuman Primate Brain
… Acute ethanol increases the function of the GABAA receptor, while chronic ethanol decreases function. Rodent studies have reported changes in gene and protein levels, receptor function, and receptor binding density in GABAA receptors and subunits after chronic ethanol, and changes in GABAB …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified. These assemble into pentameric transmembrane structures with an intrinsic …
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Cognitive and synaptic dysfunction in a mouse model of Huntington's disease
… 13 months. Drugs inhibiting the function of a5-GABAA receptors are known to enhance cognition and hippocampal LTP. In agreement, the LTP and cognitive deficits of the HdhQ111 mouse were rescued following treatment with the a5-GABAA receptors selective inverse agonist a5IA. <br/><br/>Importantly, …
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Effect of GABRA2 expression in the central nucleus of the amygdala on anxiety and alcohol's anxiolytic capacity in C57BL/6J mice
The GABRA2 gene, which encodes the α2 subunit of GABAA receptors, is one of the genes most frequently associated with alcohol-related behavior in human studies (Demers, Bogdan, & Agrawal, 2014). Polymorphisms in GABRA2 have been found to be associated with alcohol dependence, changes in drinking …
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Neuroprotectant Properties of Neurosteroids During Neonatal Ethanol Exposure
… difference in the timing of the switch of the GABAA receptor from excitatory to inhibitory in males and females, with females switching earlier than males. A significant down-regulation of GABAA receptors in the ethanol treated groups could also have made the doses of neurosteroids used in this …
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Identification of novel target genes for the plasticity-related transcription factor Zif268
… Both gephyrin and ubiquilin are associated with GABAA receptors at inhibitory synapses. Gephyrin is thought to cluster and anchor GABAA receptors at postsynaptic sites whilst ubiquilin is reported to regulate receptor surface expression. We found that gephyrin mRNA and protein expression levels …
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EFFECTS OF ALCOHOL AND ACAMPROSATE, AN ALCOHOL USE DISORDER TREATMENT, ON NONHUMAN PRIMATE BEHAVIOR AND MEMORY
… an indirect effect on mGluR, NMDA, and possibly GABAA receptors via calcium. This effect is thought to stabilize the hyper-glutamatergic state seen in withdrawal, while possibly reducing the dopaminergic response to alcohol. Acamprosate has been confirmed to be efficacious despite initial …
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Molecular characterization of the binding site of nematode GABA-A receptors
… in large part by nematocidal drugs that target receptors of the parasitic nervous system. Hco-UNC-49 is a nematode GABA receptor that has a relatively low overall sequence homology to mammalian GABA receptors but is very similar to the UNC-49 receptor found in the free living nematode …
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Synaptic Control of Dopamine as a Driver of Reward Learning
… behaviors. My key finding is that antagonizing GABAA receptors on VTADA neurons decreases the pauses in firing these cells exhibit, but also accelerates extinction learning in response to unexpected reward omission. In the same mice, the manipulation had no impact on conditioning to a novel …
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Impact of Thalamocortical Synaptic Transmission on Input specific plasticity in Mouse Auditory Cortex
… second project was to test the role of NMDA and GABAA receptors in TSMGBv-induced changes in thalamocortical fEPSPs. Microiontophoresis application of d-(-)-2-amino-5-phosphonovalerate (APV), a NMDAR antagonists and Bicuculline methiodide (BMI), a GABAA antagonists using multibarrel electrode was …
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Secondary Metabolites from Otanthus maritimus, Stachys glutinosa and Withania somnifera: Isolation, Structure Elucidation and Interactions with Cannabinoid and Opioid Systems
… metabolites that bind to CB and/or opioid receptors, we selected four extracts that showed interesting affinity versus the above mentioned receptors . In particular: the DCM extract obtained from the aerial parts of Stachys glutinosa (SGE) was able to bind with a good affinity both MOR and …
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Time-varying phase relationship between spiking neuronal responses and local field potentials in olfactory processing in manduca sexta
… potentials to LFP oscillations, and the role of GABAA receptors in the generation of these oscillations. We quantified the changes in LFP oscillation frequency over time via time-frequency representation (TFR) analysis, and calculated the timing of action potentials relative to the phase of the …
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