Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"GABAA Receptor"”.
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Structural insights into the GABAA receptor gating cycle
GABA<sub>A</sub> receptors are pentameric ligand-gated ion channels (pLGICs) that control multiple aspects of animal physiology, including the rapid inhibitory neurotransmission within the vertebrate central nervous system. They activate and desensitize in a few milliseconds, which is a crucial …
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A Structural and Computational Study of GABAA Receptor Diversity
GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that modulate the activity of neural circuits in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a …
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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
GABAA receptor binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… spiny neurons (MSNs) that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation (α2-/-) abolishes behavioural sensitisation to cocaine. Recently, linkage association studies in humans revealed a genetic association of GABRA2 haplotypes …
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… the dissociation constant (KB) of three GABAA antagonists. Neuronal networks were treated with fixed concentrations of GABAA antagonists and titrated with muscimol, a GABAA receptor agonist. Muscimol decreased spike activity in a concentration dependent manner with full efficacy (100% …
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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala
… of the differential roles GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) subtypes play in mediating various behaviors such as fear and anxiety was an intriguing research topic over the past decade. At present, most evidence suggests that benzodiazepine (BZ)-induced anxiolysis is primarily …
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Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified. These assemble into pentameric transmembrane structures with an intrinsic …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… response to GABA may be due the arterial baroreceptors buffering the actions of GABA through the contralateral RVLM. Once we inhibit the contralateral RVLM then we are able to see differences. Since the arterial baroreceptor reflex provides tonic GABAergic input to RVLM, we wanted to know if …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
… sites within a vital protein target, synaptic GABAA receptors. The molecular recognition elements for propofol-protein interactions were probed using a novel hydrogen-bond null derivative. It was determined that the propofol 1-hydroxyl is key for molecular interactions that contribute to …
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Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… glutamate efflux. NMDA and AMPA/kainate receptor antagonists also inhibited glutamate efflux, fhc group II metabotropic glutamate receptor agonist DCG-IV and the endogenous nociceptin receptor agonist nociceptin inhibited glutamate efflux whilst the group 1 mGluR antagonists MI’EP and …
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Male-specific mechanisms in a murine model of nociplastic pain
… disinhibition by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic …
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Male-specific mechanisms in a murine model of nociplastic pain
… disinhibition by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a transition to the nociplastic …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
… and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that GABA can have an anti-inflammatory effect and production of GABA by gut bacteria decreases in patients with multiple …
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