Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"GABAA"”.
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Structural insights into the GABAA receptor gating cycle
GABA<sub>A</sub> receptors are pentameric ligand-gated ion channels (pLGICs) that control multiple aspects of animal physiology, including the rapid inhibitory neurotransmission within the vertebrate central nervous system. They activate and desensitize in a few milliseconds, which is a crucial …
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
GABAA receptors (GABAARs) mediate the majority of fast inhibition in the CNS and as such are crucial to neuronal function. Two distinct modes of GABAAR mediated inhibition exist: “phasic” involves the transient activation of postsynaptic GABAARs following presynaptic vesicular GABA release and …
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A Structural and Computational Study of GABAA Receptor Diversity
GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that modulate the activity of neural circuits in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a …
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Effects of Whisker-Trimming on GABAA Receptors in S1 Cortex
… and long-term potentiation. To examine whether GABAA receptors in layers 2/3 are affected by sensory deprivation, rats had mystacial vibrissae in middle row C or rows ABDE trimmed for 6 weeks beginning in early adulthood. Layers 2/3 above the deprived and adjacent whisker barrels were located in …
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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
GABAA receptor binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, …
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Understanding the Structure and Function of GABAA Receptors Using Cryo-Electron Microscopy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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An electrophysiological study of the effects of resveratrol and catechin at GABAa receptors
… compounds, resveratrol and catechin modulate GABAA<sub>A</sub> receptors. To address this hypothesis, the effects of resveratrol and catechin were investigated on human recombinant GABA<sub>A</sub> receptors expressed in HEK-293 cells using electrophysiological techniques.<.p><p>HEK-293 cells …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… spiny neurons (MSNs) that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation (α2-/-) abolishes behavioural sensitisation to cocaine. Recently, linkage association studies in humans revealed a genetic association of GABRA2 haplotypes …
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… the dissociation constant (KB) of three GABAA antagonists. Neuronal networks were treated with fixed concentrations of GABAA antagonists and titrated with muscimol, a GABAA receptor agonist. Muscimol decreased spike activity in a concentration dependent manner with full efficacy (100% …
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Study of a Transferrin Receptor Brain Shuttle for the Delivery of Nanobodies Against GABAA Receptors
… γ-aminobutyric acid type A receptors (GABAARs). Initially, anti-GABAAR Nbs were genetically fused to the BBB shuttle, 8D3, and the impact on the Nb binding properties to GABAARs was investigated. This was to establish suitable formats for CNS delivery in the future. In addition, a range …
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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala
<p>The investigation of the differential roles GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) subtypes play in mediating various behaviors such as fear and anxiety was an intriguing research topic over the past decade. At present, most evidence suggests that benzodiazepine (BZ)-induced anxiolysis is …
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Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified. These assemble into pentameric transmembrane structures with an intrinsic …
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Maturation of GABAergic signaling during brainstem development
… hemmender Neurotransmitter über ligandgesteuerte GABAA-Rezeptorkanäle und G-proteingekoppelte GABAB-Rezeptoren. Neue Studien haben aber gezeigt, dass während der Entwicklung GABA im frühpostnatalen ZNS auch exitatorisch wirken kann. In dieser Studie untersuchten wir Faktoren, die die …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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