Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"GABA -- Receptors."”.
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The Effects of Chronic Ethanol on GABA Receptors in the Nonhuman Primate Brain
The GABAergic system is a well-known molecular target of ethanol. Acute ethanol increases the function of the GABAA receptor, while chronic ethanol decreases function. Rodent studies have reported changes in gene and protein levels, receptor function, and receptor binding density in GABAA receptors …
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A molecular characterization of agonists that bind to Hco-UNC-49, a GABA-gated chloride channel from Haemonchus contortus
… into the efficacy of a range of classical GABA receptor agonists on Hco-UNC-49 expressed in Xenopus oocytes. The results of our electrophysiological recordings indicate that there is a size requirement for full agonism of the Hco-UNC-49 binding site. Furthermore, a number of molecules that …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… inhibition in the brain is mainly achieved by GABAergic inhibitory neurons which exert their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of …
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Molecular characterization of the binding site of nematode GABA-A receptors
… in large part by nematocidal drugs that target receptors of the parasitic nervous system. Hco-UNC-49 is a nematode GABA receptor that has a relatively low overall sequence homology to mammalian GABA receptors but is very similar to the UNC-49 receptor found in the free living nematode …
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A biochemical investigation into aspects of the neuro active amino acid receptor complexes in the insect nervous system
… the glutamate (L-glu) and aminobutyric acid (GABA) receptors in the central nervous system (CNS) of the American cockroach, Periplaneta americana. The aim was to provide a simple, quick and cost effective method of screening new chemical entities as potential insecticides acting on these …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… unique parasitic nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their proximity to each …
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Investigation of two Interacting Neurosteroid Sites on a GABA Receptor by Mutagenesis and Mathematical Modeling
<p>Given the utility of GABA receptor ligands as anthelminthics and insecticides, further study of invertebrate GABA receptor modulation promises to help identify new drugs to combat emerging resistance. The C. elegans GABA receptor, UNC-49, is modulated by the neurosteroids pregnenolone sulfate …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… the LGCC gated by γ- aminobutyric acid (GABA) within H. contortus. To meet this objective, each amino acid residue in binding loop E was changed to a cysteine and analyzed via electrophysiology and the substituted cysteine accessibility method. It was found that of the 18 loop E mutants …
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
… such as cattle, sheep, and goats. UNC-49 is a GABA-gated chloride channel found to be exclusive to nematodes which could be a viable future target for anthelminthic drugs. An analysis of the model of the Hco-UNC-49 receptor has identified potentially interacting residues that may be important …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… mechanisms, either increasing inhibition via GABAA receptors (eg. Na-thiopentone) or decreasing excitation via NIvIDA receptors (eg. ketamine). The aim of this thesis is to investigate the effects of both increased inhibition and decreased excitation at the synaptic level within an …
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Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping
… by binding to the same gamma-aminobutyric acid (GABA) receptors in the central nervous system. They may be less likely than benzodiazepine medications to disrupt natural sleep rhythm and patterns which may make sleep more restful. Ramelteon (Rozerem) is a new category of sleep medications that …
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… in medicinal chemistry, is also discussed. GABAA and GABAB receptors are then presented and the synthesis of neurosteroid antagonists acting at GABAA receptors is reported. The synthesis of such compounds was motivated to explore the mode of action of neurosteroids at GABA receptors. The …
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Effects of Whisker-Trimming on GABAA Receptors in S1 Cortex
… is associated with selective decreases in GABA, GAD, and GABA receptors, in deprived areas of visual and somatosensory cortex. Those studies focused on layer 4, a recipient of direct thalamocortical sensory input. However, supragranular layers 2/3 have been recently identified as a major …
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The Role of GABA in Reproductive Neuroendocrine Systems
<p>Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.</p> <p>Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The …
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Altered GABA ergic system in the posterior hypothalamus of the spontaneously hypertensive rat
"Previous studies indicate a tonic GABAergic inhibitory mechanism in the posterior hypothalamus (PH) contributes to modulating cardiovascular activity. Blockade of GABA receptors on neurons in this area elicits an increase in sympathetic discharge, arterial pressure and heart rate. It has been …
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The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics
Gamma-aminobutyric acid (GABA) has been shown to be an important inhibitory neurotransmitter in mammalian central nervous system (CNS). GABA receptors have been previously characterized in mammalian brain using 3H-GABA itself, a potent GABA agonist, 3H-muscimol, and the GABA antagonist, …
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Starved State Dependent Modulation of Olfactory Receptor Neuron Function in Drosophila melanogaster larvae
… of ORN function by starvation is mediated by GABA signaling pathway. To investigate the molecular basis for this differential modulation, we used immunohistochemistry and gene expression analysis. We developed an antibody against the GABA (B) receptor to look at the localization of GABA …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the …
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The synthesis and biochemical and pharmacological evaluation of gamma-aminobutyric acid antagonists
… is concemed with the examination of a number of GABA antagonists in two in vitro assay systems. A series of cage-structured compounds including bicyolic phosphate esters (2,6,7,-Trioxa-l-phosphabicyclo (2,2,2,) octan-l-oxides with suitable 4-substituents) have been shown to be potent a GABA …
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Molecular pharmacology of an insect GABA receptor
Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for …
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