Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"GABA -- Antagonists."”.
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The synthesis and biochemical and pharmacological evaluation of gamma-aminobutyric acid antagonists
… is concemed with the examination of a number of GABA antagonists in two in vitro assay systems. A series of cage-structured compounds including bicyolic phosphate esters (2,6,7,-Trioxa-l-phosphabicyclo (2,2,2,) octan-l-oxides with suitable 4-substituents) have been shown to be potent a GABA …
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The Effects of Seizure Modeling and Polyphenols on Behavior in Bang-Sensitive Drosophila
… epilepsy and anxiety, possibly mediated through GABAergic pathways. Bang-Sensitive Drosophila mutants model epileptic seizures following mechanical shock and provide a high-throughput alternative to costly rodent studies. The objectives of this study were to: 1) examine the effectiveness of …
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The role of the GABAergic system in the production of ultrasonic vocalization in rats /
… AH/POA could trigger vocahzation, and that the GABAergic system could be involved. The purpose of this study is to investigate the effects ofGABA agonists and antagonists on flie production of carbachol induced 22kHz vocalization. The following hypotheses were examined: 1) apphcation ofGABA (a …
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… the dissociation constant (KB) of three GABAA antagonists. Neuronal networks were treated with fixed concentrations of GABAA antagonists and titrated with muscimol, a GABAA receptor agonist. Muscimol decreased spike activity in a concentration dependent manner with full efficacy (100% …
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An electrophysiological study of the effects of resveratrol and catechin at GABAa receptors
… compounds, resveratrol and catechin modulate GABAA<sub>A</sub> receptors. To address this hypothesis, the effects of resveratrol and catechin were investigated on human recombinant GABA<sub>A</sub> receptors expressed in HEK-293 cells using electrophysiological techniques.<.p><p>HEK-293 cells …