Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"GABA(A) receptor"”.
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Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
Numerous previous studies of GABAAR ligands have suggested that GABAAR agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7-6.0 Ã ). We have demonstrated that monomeric, homodimeric and heterodimeric non-zwitterionic GABA amides are partial, full, …
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Investigation of an unusual GABA-A receptor: studies on the promiscuous ε [epsilon] subunit
γ-aminobutyric acid (GABA) type A (GABAA) receptors are pentameric, chloride-selective ion channels. Nineteen different GABAA receptor subunits are known to exist in man and various subunit combinations are able to form receptor subtypes with different, subunit-specific pharmacological properties. …
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GABA-A Receptor Subunit Gene Expression as a Biomarker for Perimenstrual Change in Affect and Suicidality
… sensitivity remain unknown. Altered GABAergic neurotransmission due to aberrant interactions between the GABA-A receptor and progesterone-derived neuroactive steroids represents a compelling candidate mechanism of MCAC. Briefly, progesterone and its neuroactive steroid metabolites …
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Specifying molecular determinants of the subcellular targeting of synaptic and extrasynaptic GABA A receptors
How GABA-A receptor subtypes segregate so precisely to different subcellular locations is not understood. In this study, I have expressed the recombinant g2 and d GABA-A receptor subunits in cultured hippocampal neurons to analyze the differential cell surface expression and sub-membrane …
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Decompositions of Free Energies in Molecular Simulation
… about the binding conformation of two proteins GABARAP and the GABA-A receptor. In chapter 6 statistics from hydration sites around hundreds of proteins are analysed. The distributions of free energy are shown and discussed for hydration sites in a range of local chemical environments. Also in …
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Effects of constitutive and acute Connexin 36 deficiency on brain-wide susceptibility to PTZ-induced neuronal hyperactivity
… utilize the zebrafish pentylenetetrazol (PTZ; a GABA(A) receptor antagonist) induced seizure model, taking advantage of the compact size and optical translucency of the larval zebrafish brain to assess how PTZ affects brain-wide neuronal activity and Cx36 protein expression. We exposed wild-type …
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Neonatal exposure to estradiol in female rats influences neuroactive steroid concentrations and behaviour in the adult rat
… to the positive allosteric modulator of the GABAA receptor, diazepam. These effects of estradiol suggest that it plays a major role in pharmacological regulation both of GABAergic transmission and of the abundance of endogenous modulators of such transmission during development of the central …