Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 307 for “"GABA"”.
-
Entwicklungsspezifische Wirkmechanismen der Neurotransmitter GABA und Glyzin
… einher. Während die Neurotransmitter GABA und Glyzin Nervenzellen des adulten Gehirns hyperpolarisieren und dadurch Aktivität hemmen, depolarisieren sie paradoxerweise unreife Nervenzellen und rufen dadurch Kalziumsignale hervor. In der vorliegenden Arbeit wurden die Rolle und der …
-
Molecular pharmacology of an insect GABA receptor
… receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for insecticides. The aim of this dissertation was to characterise RDL receptors with particular focus on the agonist binding site. To assess the potency of a range …
-
Freisetzung von zytoplasmatischem GABA ([3H]-GABA) und Glutamat (D-[3H]-Aspartat) durch Transporterumkehr (Heteroexchange) im Striatum von Ratte und Kaninchen
… Modell der zytoplasmatischen Freisetzung von GABA, bzw. D-Aspartat durch die Umkehr des plasmamembranären Transporters. Zur Validierung unserer Methodik schlossen wir die Beteiligung eines vesikulären Freisetzungsmechanismus aus und bewiesen durch die Blockade des Wiederaufnahme-Transporters …
-
The Role of GABA in Reproductive Neuroendocrine Systems
<p>Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.</p> <p>Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The …
-
Effects of GABA on inflammation and intestinal barrier disruption
… reducing frequencies of gamma-aminobutyric acid (GABA)-producing bacteria. GABA levels are reduced in the brains and circulation of MS patients. We engineered Lactococcus lactis with extra copies of gadB (glutamic acid decarboxylase) and gadC (glutamate/GABA antiporter) to increase GABA levels …
-
GABA regulation of gas exchange in barley (Hordeum vulgare)
… and stress. During stress, rapid accumulation of GABA (γ-aminobutyric acid) can occur through the GABA shunt, which bypasses two stress-inhibited reactions of the mitochondrial based TCA cycle. This observation makes GABA well known as a stress metabolite in plants. Far beyond this, evidence in …
-
Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
… (ARC). The VMN and PVN have a unique pattern of GABA expression in elements surrounding the nuclei, with a void of GABA within the region of the developing nuclei. The ARC, on the other hand, has dense GABAergic immunoreactive elements throughout the nucleus. Because of the expression pattern of …
-
The role of GABA in plant salinity and hypoxia responses
… better understanding of how γ-aminobutyric acid, GABA, contributes to the stress responses of plants, using the model plant Arabidopsis thaliana wild type (WT) and GABA mutants. Some mutants target decreased GABA production due to T-DNA insertion(s) in the major GABA producing gene(s) Glutamate …
-
Systemic administration of putrescine induces GABA-like behaviors in rats
… neurotransmitter, gamma-aminobutyric acid (GABA). Conversion of systemically administered putrescine to GABA in rat neural tissues has been reported. In this thesis, three experiments were conducted to characterize changes in rat behavior after putrescine administration, and determine if any …
-
Molecular characterization of the binding site of nematode GABA-A receptors
… nervous system. Hco-UNC-49 is a nematode GABA receptor that has a relatively low overall sequence homology to mammalian GABA receptors but is very similar to the UNC-49 receptor found in the free living nematode Caenorhabditis elegans. However, the nematode receptors do exhibit different …
-
Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
… channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B subunit forms a functional homomeric channel in Xenopus laevis oocytes that produces a robust response to GABA and is highly sensitive to picrotoxin. In …
-
Molecular and ontogenic analysis of the mammalian GABA<sub>A</sub> receptor
… role during CNS development. Diversification of GABA<sub>A</sub> receptor mediated responses are in part a result ofvariation in subunit composition in the receptor complex. This variation arises both from the number of different subtypes of GABA<sub>A</sub> receptor subunits (α1-6, β1-4, γ1-3, …
-
DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… aversion, motivation and cognition. However, VTA GABA cells, while long understudied, are increasingly recognized as powerful mediators of reward and potential therapeutic targets for addiction, depression and other stress-linked neuropsychiatric disorders characterized by disruptions in reward …
-
Immune stress and reproduction : insights into the role of norepinephrine and GABA
Thesis (Ph.D.)--Michigan State University. Department of Comparative Medicine and Integrative Biology, 2008
-
Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the mammalian brain, underlying diverse functions from the maintenance of consciousness and the formation of memories to the regulation of the processes underlying brain development and circadian rhythms. While GABAergic …
-
Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
Numerous previous studies of GABAAR ligands have suggested that GABAAR agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7-6.0 Ã ). We have demonstrated that monomeric, homodimeric and heterodimeric non-zwitterionic GABA amides are partial, full, …
-
The Effects of Chronic Ethanol on GABA Receptors in the Nonhuman Primate Brain
The GABAergic system is a well-known molecular target of ethanol. Acute ethanol increases the function of the GABAA receptor, while chronic ethanol decreases function. Rodent studies have reported changes in gene and protein levels, receptor function, and receptor binding density in GABAA receptors …
Page 1 of 16