Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"G9a"”.
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Studies on the Histone Methyltransferase G9a
… of the H3K9-specific methyltransferases G9a and GLP. These studies demonstrate that G9a is essential for B cell development in the mouse, but is dispensable for T cell development. The defect in B lymphopoiesis in the absence of G9a is caused by a block in development at the pro-B cell …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… evidence that the lysine methyltransferase G9a represses expression of several sarcomeric genes, whereby over-expression of G9a disrupts sarcomere integrity of skeletal muscle cells. This inhibition is mediated by G9a catalyzation of repressive histone methylation marks at sarcomeric gene …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… rewiring conferred sensitivity to G9a inhibitors. G9a inhibition promoted recurrent tumor cell necroptosis through demethylation of genes involved in a pro-inflammatory cytokine program. Further, knockout of G9a protein delayed the time until mammary tumors recurred in vivo. …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… for VSMC gene regulation the methyltransferase G9A/GLP was pharmacologically inhibited in vitro and in vivo. The resulting loss of H3K9me2 attenuated the expression of contractile VSMC markers and significantly potentiated IL-1α/injury-induced expression of MMP and pro-inflammatory genes. …
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
… the novel interaction of MYC and the G9a histone methyltransferase and demonstrated their coordinated regulation of genome-wide transcriptional repression. This interaction and their resulting gene expression output support breast cancer growth, which is impaired with G9a inhibition. …
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Enhancement of death receptor-mediated apoptosis in multiple myeloma cells
… or inhibitors of the histone methyltransferases G9a and EZH2 (BIX 01294 and GSK343) and Nuclear export inhibitor (NEI) LMB, enhance TRAIL-induced apoptosis and overcome TRAIL resistance in both suspension culture, and 3D cell culture as a model of solid disseminated MM lesions that form in bone. …
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Role of ORCA and ORC in chromatin organization and DNA replication
… and interacts with repressive KMTs, including G9a/GLP and Suv39H1 in a chromatin context-dependent manner. Single-molecule pull-down assays demonstrate that ORCA-ORC and multiple H3K9 KMTs exist in a single complex and that ORCA stabilizes H3K9 KMT complex. Cells lacking ORCA show alterations …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes. Also preference of Arg at –1 position and a smaller amino acid at –2 position was identified. The results obtained are consistent with lax substrate specificities observed for the …
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Mechanisms and functional significance of nuclear compartmentalization
… several hundred kilobases surrounding HBB and on G9a-mediated H3K9me2 methylation over flanking sequences in an adjacent Lamin Associated Domain. Our results demonstrate multiple cis elements regulate the overall balance of specific epigenetic marks and peripheral gene targeting.
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… I reported that histone methyltransferase G9a is present in a SHP complex and enhances SHP inhibitory activity to suppress CYP7A1 expression. Besides cholesterol/bile acid homeostasis, FXR and SHP are involved in other metabolic pathways such as glucose homeostasis and fatty acid metabolism …
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Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
… Motiv wird auch von der Lysinmethyltransferase G9a modifiziert und benachbarte Serine tragen eine Mitose-abhängige Phosphorylierung. Diese Beobachtungen führen zu der These, dass diese verschiedenartig modifizierte Region in die Regulation von CDYL1-basierten Interaktionen involviert ist. Am …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… mSin3A/HDAC1, NCoR1/HDAC3, methyltransferase G9a, and the Swi/Snf-Brm remodeling complex, to the CYP7A1 promoter. Mutation of the Arg-57 site to Trp (R57W is the naturallyoccurring mutant) decreased SHP interaction with corepressors that we had previously identified, and severely impaired …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… several classes of ‘epigenetic drugs’ such as a G9a/GLP histone lysine methyltransferase inhibitor that was ineffective in reducing ALCL cell viability when used as a single agent. In conclusion, METTL3 is a novel downstream effector of NPM-ALK activity that acts in an oncogenic capacity to drive …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… methyltransferases 1 and 2 (EHMT1/GLP and EHMT2/G9a) were reduced. Consistently, microRNA-217-induced genetic or pharmacological inactivation of Ehmts was sufficient to promote pathological hypertrophy and foetal gene re-expression, while suppression of this pathway protected from pathological …