Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"G93A mutant SOD1"”.
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Recombinant DDX58 associates with SOD1 protein and selective miRNA changes in secreted EVs
… to ALS, as it was found upregulated in SOD1 and TDP-43 ALS models. Therefore, we decided to investigate DDX58 in connection to EVs and their paracrine effects. In NSC34 cells, we observed that recombinant DDX58-tGFP displays an intracellular distribution that partially reaches the …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… to mutations in Cu/Zn superoxide dismutase (SOD1), resulting in mitochondrial oxidative stress and intrinsic apoptosis. Transgenic mice expressing a G93A mutant of SOD1 provide an in vivo model to investigate motor neuron death during disease progression. The principal regulators of intrinsic …