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Showing 1 to 18 of 18 for “"G6pd"”.
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
… on p53, glucose 6-phosphate dehydrogenase (G6PD), and c-Myc, all of which are known to play a major role in cancer development. p53 is a tumor suppressor protein, often mutated in cancers causing its inactivation. Expression of G6PD is elevated in many cancers, and this significantly …
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A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia
BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans and affects over 400 million people worldwide, majority being in Africa. G6PD catalyses the first reaction of the pentose phosphate pathway where it plays a role in generation of NADPH, …
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A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia
BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans and affects over 400 million people worldwide, majority being in Africa. G6PD catalyses the first reaction of the pentose phosphate pathway where it plays a role in generation of NADPH, …
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Regulation of glucose -6 -phosphate dehydrogenase by polyunsaturated fatty acids in cultured rat hepatocytes
… is liver glucose-6-phosphate dehydrogenase (G6PD). In order to determine if regulation of G6PD occurred at a transcriptional or a posttranscriptional step in rat hepatocytes, enzyme activity, mRNA accumulation and transcriptional activity of the G6PD gene were measured in the presence and …
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DESIGN AND INVESTIGATION OF DUMBBELL-SHAPED DNA MINIMAL VECTORS FOR CRISPR/CAS9 EDITING
… targets, i.e. glucose-6-phosphate dehydrogenase (G6PD) Mahidol, G6PD Mediterranean and Southeast Asian Ovalocytosis, and a dual reporter assay, we demonstrated that dumbbell vectors offer a viable alternative to plasmids for delivery of the CRISPR/Cas9 gene editing tool. Our analyses of sgRNA …
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Electrostatic and affinity enhancements of protein partitioning in two-phase aqueous micellar systems
… of the enzyme glucose-6-phosphate dehydrogenase (G6PD) in two-phase aqueous mixed (nonionic/cationic) micellar systems was investigated experimentally and theoretically. The successful enhancement, up to 22-fold, of the partitioning of the negatively-charged G6PD was attained by adding the …
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The Economics of Vivax Malaria Treatment
… screening for glucose-6-phosphate-dehydrogenase (G6PD) deficiency prior to radical cure reduced the disease burden while being a cost-effective option for healthcare providers that do not use radical cure and a potentially cost-saving alternative where primaquine is prescribed without screening. …
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Covalent Binding and other Mechanisms of Primaquine Toxicity
… to the total protein of both normal and G6PD-deficient erythrocytes.. The net binding to the protein of G6PD-defi ci ent red cells was significantly greater than that to normal cells. A measurable amount of covalent binding of PQ metabolite(s) to human hemoglobin was also demonstrated. A …
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Διαδερμική μέτρηση χολερυθρίνης στα νεογνά : στρατηγικές πρόγνωσης σημαντικής υπερχολερυθριναιμίας
… ζωής. Οι ασυμβατότητες αίματος και η ανεπάρκεια G6PD επηρεάζουν τον ρυθμό αύξησης της χολερυθρίνης νωρίτερα (στις πρώτες 36-48 ώρες) σε σχέση με την προωρότητα, την απώλεια βάρους και τον αποκλειστικό μητρικό θηλασμό που επιδρούν αργότερα. Συμπεράσματα: Η παρούσα μελέτη προσφέρει στοιχεία για τη …
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Regulation of cellular glucose metabolism by HIV-1 infection
… (HK), glucose-6-phosphate dehydrogenase (G6PD) and pyruvate kinase muscle type 2 (PKM2) that facilitates viral replication and biogenesis, and long-term survival of macrophages. We then focused on infected monocyte macrophages to identify if glycolytic components such as HK and G6PD were …
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The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease
… activation of glucose 6-phosphate dehydrogenase (G6PD), the rate limiting step for the pentose phosphate pathway. This metabolic pathway is responsible for producing NADPH, which in turn NADPH oxidases exploit for further ROS production. These changes resulted in noticeable reductions in both …
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Untersuchungen zur genetischen Regulation der CO<sub>2</sub>-Assimilation in <i>Ralstonia</i> spp.
… einer Glucose-6-phosphat-Dehydrogenase (G6PD) und einer Phosphoglucose-Isomerase (PGI) ein Operon. In einer frcR-Deletionsmutante waren die Aktivitäten der G6PD und der PGI deutlich erhöht, zeigten aber weiterhin eine Abhängigkeit von den jeweiligen Wachstumsbedingungen. FrcR scheint …
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An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
… in sub-Saharan Africa. Unlike HbAS, HbAC and G6PD deficiency there remains debate about whether alpha+-thalassaemia protects against malaria and the mechanism for the protection. Methods: 1672 children of ≤10 years were recruited and individuals with G6PD deficiency, HbAC and Hb AS reported to …
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Efeito do cromossomo x no mapeamento de regiões genômicas sobre características de interesse econômico em búfalos da raça murrah
… SLC6A14), and CFI2 (RPS6KA6, PCDH11X, PABPC5, G6PD, GDI1, RPL10, FLNA, MECP2, and L1CAM). This study provided greater insight into the strong association of X chromosome markers with reproductive traits in females, and these findings may contribute to understanding economically relevant …
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The Mechanism of Palmitate Decreased Glucose Transpoter 4 Expression in C2 Myotubes
… 41 2. 고농도 지방산에 의한 glycolysis 관련 유전자 발현 변화 41 3. G6PD 발현 억제 및 과 발현에 의한 GLUT4 유전자 발현 변화 42 Ⅳ. 고찰 48 A. 고농도 지방산의 지속적 노출에 의한 인슐린 저항성 및 GLUT4 양적 감소 48 B. 고농도 지방산의 지속적 노출에 의한 GLUT4 양적 감소 기전 분석 49 C. 고농도 지방산에 의한 pyruvate 양적 변화 및 pyruvate와 palmitate 산화 변화 50 D. 고농도 지방산에 의한 glycolysis 관련 유전자 발현 변화 51 Ⅴ. …
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
… had moderately severe/severe malaria, history of G6PD deficiency or allergy to study drugs, or serious underlying disease. Patients were randomly assigned to sulfadoxine-pyrimethamine (SP): a single oral 25/1.25mg per kg dose on Day 0, with a maximum of 3 tablets), or artesunate (AS) plus SP: SP …
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Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes
… in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals. Phenolic and quinone metabolites generated via cytochrome P450-dependent pathways appear to be responsible for hemolytic effects of PQ. However, the mechanism for the hemolytic toxicity of PQ is still poorly understood. To …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… glucose 6-phosphate dehydrogenase (G6PD) and desuccinylating superoxide dismutase 1 (SOD1). Recent studies revealed that SIRT5 knock-down in human breast and lung cancer cells inhibited their transformed properties, whereas it had no significant effect on the growth of normal cells. …