Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"G4"”.
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G-wires: The growth and characterization of a G4-DNA nanostructure
… (G'2-DNA) and parallel tetramer conformations (G4-DNA). In this work we have employed the techniques of gel electrophoresis, UV spectroscopy and atomic force microscopy (AFM) to study a new G4-DNA nanostructure. The oligonucleotide d(GGGGTTGGGG) (Tet1.5) self-assembles into highly ordered …
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Unveiling Global Roles of G-Quadruplexes and G4-22 In Human Genetics
… though previous studies showed the impact of G4 in gene expression, none of them summarized the location-specific effect of G4. Also, there is no broad understanding about the most common G4 repeat in the human genome, named here as G4-22, and how it links to the evolution of mammals and their …
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Pupils' Attitudes Towards Technology – Grade 4 (PATT-G4): Establishing A Valid and Reliable Instrument
… Attitudes Towards Technology – Grade 4 (PATT-G4) for use with 4th grade students to assess their attitudes and concepts toward contemporary technology. A literature review reviewing the theoretical frameworks for technology education, the educational shift towards technological literacy as …
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G4-RESOLVASE 1 TIGHTLY BINDS AND CATALYTICALLY UNWINDS UNIMOLECULAR G-QUADRUPLEX STRUCTURES WITH IMPLICATIONS FOR GENE TRANSCRIPTION AND TELOMERE BIOLOGY
G-quadruplexes (G4s) are four-stranded structures formed by guanine-rich DNA or RNA sequences in which the strands can be orientated in parallel, antiparallel, or mixed parallel/antiparallel orientations. It has been previously shown that the DHX36 gene product, G4-Resolvase1 (G4R1), binds parallel …
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Critical assessment of environmental sustainability reporting using the GRI G4 guidelines: A case study of the South African gold sector
… that disclose performance according to the GRI G4 Guidelines, and semi-structured interviews with key internal and external stakeholders. The analysis shows that while sustainability reports in the South African mining sector have been found to have beneficial functions for both internal and …
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Investigation of Genomic Instability Induced By G-Quadruplexes In The Absence of Functional to poisomerase 1 In Yeast
… DNA leads to the formation of G-quadruplex (G4) structures, Top1’s function likely suppresses G4-formation. In support of this, Top1 significantly reduces co-transcriptional G4 DNA-associated genomic instability at a model G4-motif in <em>Saccharomyces cerevisiae</em>. However, whether Top1 …
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Identification et caractérisation des G-quadruplexes dans le transcriptome humain
… tetrahelical structure called G-quadruplex (G4). In RNA, these structures can be associated with several of post-transcriptional roles such as translation, splicing and polyadenylation. However, the assessment and study of G4 structural contributions at the RNA level remains in its early …
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Pottery Horizons of the Jalul Ceramic Assemblage in the Iron Age IIA-C from Square G4 in its Historical and Geographical Context
… the selection of Jalul pottery from Field G4 that is relevant for a typological and chronological study; and a typological examination of this pottery.</p> <p>The Results</p> <p>The Courtyard and Pottery Room in Field G4 differ in their stratigraphy and ceramic accumulation. The Courtyard …
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DNA G-quadruplex structures in human cancer cells
… and diseases. In particular, G-quadruplexes (G4s), four-stranded structures formed in guanine-rich sequences of cellular chromatin, are implicated in transcription, replication and genome stability. G4s may also present new opportunities for targeting in anti-cancer therapeutic interventions …
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Single-molecule G-quadruplex visualisation in live cells and 3D chromatin
The G-quadruplex (G4) is a secondary DNA structure formed by the self-assembly of guanine nucleotides. Mapping G4 formation in the human genome shows that they are enriched in functionally important regions such as promoters, enhancers, transcription factor and architectural protein binding sites. …
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Investigating the function of DNA G-quadruplex structures in human enhancers
… molecular structures. DNA G-quadruplexes (G4s) are four-stranded DNA three-dimensional (3D) structures, that form in guanine-rich regions of the genome. G4s are enriched at sites of important regulatory potential in diverse genomes, including promoters and enhancers. Enhancers interact with …
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Investigating DNA G-quadruplex structure function through genome and epigenome engineering
… such as four-stranded DNA G-quadruplexes (G4s), in genome function remains a largely unanswered question. G4s are implicated in transcriptional regulation; however, earlier studies are mostly correlative and do not directly address the role of an individual G4 within its endogenous cellular …
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Development of Two Novel Families of Platinum(Ii) Coordination Complexes for Nucleic Acid Recognition
… architectures, such as guanine quadruplexes (G4s). These four stranded assemblies have risen to prominence as promising drug targets as a result of their demonstrated relevance and enrichment in genomic regions involved in cancer, neurodegenerative conditions, bacterial infections, and viral …
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Sequence Effects and Ligand Selectivity in Targeting Non-Canonical DNA Structures
G-Quadruplex (G4) DNA is a secondary DNA structure that can occur in G-rich DNA sequences. These structures, which are compact and diverse, have been implicated in a wide range of processes including telomere maintenance, transcriptional control, and DNA replication and repair. In order to target …
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Investigating the interactions of G-quadruplexes with transcription and chromatin structure
Four stranded G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that are primarily found in nucleosome-depleted promoters and mark sites of elevated transcription within the human genome. Although numerous studies have indicated an association between G4 formation and active …
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Development of nanobodies as tools to investigate G-quadruplex DNA secondary structures
… secondary structures called G-quadruplexes (G4). G4s are suggested to be involved in key genome functions such as transcription, genome stability and epigenetic regulation, together with numerous connections to cancer biology. The detection G4s in cells has been facilitated by the use of …
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Exploring genetic interactions with G-quadruplex structures
… translation and telomere biology. Aberrant G4 formation and stabilisation have been linked to genome instability, cancer and other diseases. However, the specific genes and pathways involved are largely unknown, and the work within this thesis aims to investigate this. Stabilisation of G4s …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
… cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain switch (S) regions in the DNA for CSR. Sequence alignment revealed homology between the AID G4 binding domain and the RNA helicase associated with …
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Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures that exit in various biologically important regions within a cell, such as the promoters of DNA, 5’-Untranslated regions (UTR) of mRNA and telomeres. These secondary structures tend to cluster around 1 kb from transcriptional …
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Genetic selection of cyclic peptide G-quadruplex ligands
… molecular probes that bind the G-quadruplex (G4) nucleic acid structure have been instrumental in demonstrating the existence and biological importance of these non-canonical secondary structures. There is increasing evidence that G4s present new opportunities in treating cancer and …
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