Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"G3BP1"”.
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The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication
<p>G3BP1/2 are RNA-binding proteins that promote condensation to form stress granules in response to various cellular stresses, including viral infection. G3BP1/2 are prominent interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the …
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… of the peripheral myelin protein (PMP22) by the G3BP1 isoform. The previously reported growth suppressing effects by PMP22 was here verified in breast cancer cells and we could show that G3BP1 influences growth regulation by reducing PMP22 expression, although not through mRNA destabilizing …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
… <p>We firstly confirmed that the NTF2L domain of G3BP1 protein, the central node of the SG interaction network, is a date hub that interacts with SLiMs. We found that the NTF2L domain has one binding surface, comprising four closely neighboring, degenerated binding areas. We then defined the SLiM …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… in vascular cells. Reduction of SG component G3BP1 by siRNA knockdown significantly reduced stress granule formation and inflammatory gene abundance in hVSMC. Microtubule inhibitors reduced SG formation in hVSMC. These results support the hypothesis that SG formation in atherosclerosis is …
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
… the MAGE-B2 mouse ortholog or overexpression of G3BP1 confers hypersensitivity of the male germline to heat stress in vivo. Thus, MAGE-B2 provides cytoprotection to maintain mammalian spermatogenesis, a highly thermo-sensitive process that must be preserved throughout reproductive life. These …
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PART I CRYSTAL STRUCTURE OF A DIMERIZATION DOMAIN OF DROSOPHILA CAPRIN. PART II CHARACTERIZATION OF TWO CAS13B CRISPR-CAS SYSTEMS FROM PORPHYROMONAS GINGIVALIS
… (FMRP), Ras-GAP SH3 domain-binding protein 1 (G3BP1), and the Japanese encephalitis virus (JEV) core protein. We have determined the crystal structures of a fragment (residues 187-309) of Drosophila Melanogaster Caprin (dCaprin), which mediates homodimerization through a substantial interface …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… knockdown of critical SG components (G3BP1 and G3BP2) did not affect viral replication. Interestingly, we found that the PRRSV-induced SGs are formed in a PERK-dependent manner. PERK is an important sensor of ER stress and activator of the unfolded protein response (UPR). Further …
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RNA binding proteins in neurotoxic protein clearance
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process whereby cellular cytoplasmic contents are sequestered in double membraned vesicles and delivered to lysosomes for proteolytic degradation. Dysfunction in the autophagic machinery or in the lysosomes …