Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"G2 Phase"”.
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Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)
… Die quantitativen Proteinexpressionen von den G1-Phase-Proteinen E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und …
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Validierung der Zellzyklusdiagnostik bei Ataxia telangiectasia
… Zellen (G0,G1) sowie den Anteil der in der G2-Phase des 1. Zellzyklus verbleibenden Zellen bezogen auf die Wachstumsfraktion (G2/GF). Der Anteil der nicht-proliferierenden Zellen (G0,G1) ist ein Maß für die Stimulierbarkeit der Lymphozyten. Diese Stimulierbarkeit ist bei Zellen von …
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Mapping the cell cycle-dependent centrosomal interactome
… that this protein participates in the G1/S and G2/M transition when depleted using the auxin-inducible degradation system. Unfortunately contrary to the enrichment results, fluorescently tagged AATF-AID2-mNeonGreen was found to be predominantly localised on the nucleolus. Similarly, …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… then assayed for cell proliferation, cell cycle phase distribution and AKT phosphorylation. In U87MG cells, 50% of the PTEN mutants (Y65C, K125E, E150Q and D153Y) exhibited statistically significant reductions in cell proliferation, but not to the level of that of WT PTEN. In both the HCT116 and …
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Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia
… demonstrate a prolonged passage through late S/ G2 phase of cell cycle in comparison to cells treated with gemcitabine alone. This coincides with inhibition of resolution of γH2AX foci. Our findings also demonstrate that thermal sensitization of human hepatocellular carcinoma cell lines to …
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Analysis of Interphase Chromatin Motion in HeLa Cells
… techniques were used to characterize interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication prior to cell division with the assistance of replication proteins (machinery) which modify chromatin mobility. Using dual color imaging of flourescently tagged …
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The effect of doxorubicin on the U2OS cell cycle
… When a 2 [mu]M dose is applied to the cells, a G2 arrest occurs. This is shown by lower levels of Cyclin B in the G2 phase during flow cytometry analysis and staining with PI. Apoptosis levels are monitored using cleaved Caspase 3 and cleaved PARP. The percentage of 10 [mu]M cells undergoing …
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Hsp90 as a molecular target
… Cell cycle analysis carried out reported S and G2 phase arrest, post Hsp90 inhibition by either 17AAG or shhsp90α. Interestingly, it was reported that 17AAG shows a better silencing profile compared to shhsp90α. To analyse the downstream effects of Hsp90 inhibition and to determine the client …
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The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
… cyclin B3 resulted in the elongation of the S-phase at the expense of the G2 phase in the 2-cell embryo and a suppression of ZGA-related genes. This effect was partially rescued when embryos were forced through the cell cycle by exposure to a Chk1 inhibitor. Conversely, elongation of the G2 …
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Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
… for ensuring the accurate progression of each phase. When abnormalities occur in the proteins governing these checkpoints, diseases such as cancer frequently arise. These checkpoints include the G1/S transition, where cancer-associated mutations are most prevalent, the G2/M transition, and the …
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caffeine에 의한 HGF-induced G2 delay 촉진효과 확인 및 기전분석
… study, we explored the role of caffeine in G2 delay induced by HGF. Previously, we have shown that HGF induced transient G2 delay via ERK pathway. To address the involvement of ATM/ATR kinases in HGF-induced G2 delay, caffeine was used as an inhibitor. Interestingly, caffeine couldn't …
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Mosaikbildung bei Fanconi-Anämie
… durch einen erhöhten Anteil von Zellen in der G2-Phase in der Durchflußzytometrie. Bei einigen Patienten wurden Verläufe mit stabilen Blutbildern beschrieben. Als Erklärung wurde das Vorhandensein einer Mosaikkonstellation bei diesen Patienten diskutiert. Hier wird ein FA-Patient der …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… Using cell synchronization techniques, different phases of cells in cell cycle were collected and analyzed for the changes in mitochondrial DNA copy number and mitochondrial mass. We found that mitochondria mass gradually increased from G1 phase to mitotic phase and reduced back at the returning …
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Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
… expression and induced cell cycle arrest in the G2 phase. Further studies are warranted to determine the malignant or proliferative role of LRF in human breast carcinoma.
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Consequences of partial chromosome re-replication in mammalian cells
… origins by Mcm2-7 is prevented during S and G2 phases. Metazoans<br/>achieve this by cell cycle regulated proteolysis of the essential licensing factor<br/>Cdt1 and formation of an inhibitory heterohexameric complex of Cdt1 with a<br/>small protein called geminin. The consequences of either …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… (DHC) and fisetin, induced S and G2 phase cell cycle arrest in LNCaP and PC3 prostate cancer cells. Gene expression studies employing oligonucleotide microarray demonstrated profound down-regulation in gene expression of 75 key cell cycle (predominantly G2 and M phase) genes by DHC …
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Telomere-Driven Tetraploidy and its Relevance to Cancer
… of persistent DNA damage induce a prolonged G2 phase followed by by-pass of mitosis, re-entry into S phase, and whole genome reduplication. Endoreduplication requires an ATM and/or ATR-dependent DNA damage signal, blocking the activation of Cdk1/CyclinB and mitosis. Furthermore, we …
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The Role of the Stress Response Gene Gadd45b in Senescence
… to other senescent MEFs, which arrest at G1 phase of cell cycle, Gadd45b null MEFs arrest at the G2/M phase of cell cycle. Furthermore, FACS analysis of Gadd45b null MEFs showed less phospho-histone H3-positive cells compared to wild type MEFs indicating that Gadd45b null MEFs are arrested in …
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Function of MCPH1 in Neurogenesis
… zentrosomale Lokalization von Chk1 in der G2-phase des Zellzyklus. Zentrosomal lokalisiertes Chk1 verhindert einen Eintritt in die Mitose durch temporäre negative Regulation von Cdc25B und Cdk1. Mcph1-defiziente Zellen aktivieren frühzeitig Cdk1 und leiten einen vorzeitigen Eintritt in die …
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Involvement of Scribble protein in breast cancer invasion and metastasis
… more D-mutant expressing cells in the G2 phase of the cell cycle. Protein interaction study was also conducted. The binding partners of S[1306+1309]A and S[1306+1309]D mutants of scribble were captured and analysed by Co-IP and mass spectrometry. Bioinformatics analysis identified the …
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