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Showing 1 to 20 of 405 for “"G2"”.

  1. Mathematical Modeling Reveals That G2/M Checkpoint Override

    Hsieh, Hui Ju, <p>orcid.org/0000-0002-2583-7670</p>2018

    … Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling pathway controls a transcriptional program of mitotic entry through …

    uthsc Repository record

  2. Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells

    Khazai, Shahin2017

    … which then bind to and activate CDKs. Cyclin G2, an unconventional cyclin, negatively regulates cell cycle and its levels are lowered in various types of cancer. Our lab has previously reported that cyclin G2 is an unstable protein, which is degraded by the UPP. Through a series of in vitro …

    york Repository record

  3. caffeine에 의한 HGF-induced G2 delay 촉진효과 확인 및 기전분석

    이, 민우2011

    … study, we explored the role of caffeine in G2 delay induced by HGF. Previously, we have shown that HGF induced transient G2 delay via ERK pathway. To address the involvement of ATM/ATR kinases in HGF-induced G2 delay, caffeine was used as an inhibitor. Interestingly, caffeine couldn't …

    ajou Repository record

  4. Deciphering the role of BRCA2 at the damage-induced G2 checkpoint

    Ahmad, Syed SaifUniversity of Cambridge2018

    Loss of DNA damage-induced G2 checkpoint control is associated with genome instability, tumour formation and the therapeutic response of tumours to genotoxic agents. The large 3418 residue protein encoded by BRCA2 – heterozygous germline mutations in which predispose to cancer - has recently been …

    cambridge Repository record

  5. The Role and Regulation of Cyclin G2 in Human Ovarian Cancer Cells

    Bernaudo, Stephanie2015

    … the unconventional G-type cyclins (cyclin G1, G2, and I) act to oppose cell cycle progression. Indeed, dysregulation of the cycle cell is an important molecular mechanism that is frequently altered in cancers, including EOC. Interestingly, recent evidence has suggested that the loss of cyclin …

    york Repository record

  6. Non tutti gli stranieri sono immigrti. Questioni e forme di cittadinanza: il "caso" G2

    SILIGATO, LAURAUniversità degli studi di Catania2012

    Uno dei principali problemi che ostacolano l integrazione dei migranti è l'intensa relatività giuridico-culturale che talvolta guida le loro azioni. Si tratta di una differente percezione della quotidianità che non si presenta solo come scontro tra culture di derivazione territoriale diversa, ma …

    catania Repository record

  7. Metabolism and Mammary Transport Mechanism of Immunoglobulins G1 and G2 in the Dairy Cow

    Sasaki, MasaoUniversity of Illinois at Urbana-Champaign2014

    Made available in DSpace on 2014-12-14T15:29:40Z (GMT). No. of bitstreams: 1 7709167.pdf: 5217603 bytes, checksum: 5a37b0a56d927b6299d6601e28584fc1 (MD5) Previous issue date: 1976

    uiuc Repository record

  8. The Tumor Suppressor PKCδ Is Critical for UV-Induced G2/M Checkpoint Activation and Apoptosis

    Lagory, Edward Lewis2016

    … expression of PKCδ-cat caused a pronounced G2/M cell cycle arrest in both primary human KCs and immortalized HaCaT cells. Consistent with a G2/M arrest, PKCδ-cat induced phosphorylation of Cdk1 (Tyr15), a critical event in the G2/M checkpoint. Treatment with the ATM/ATR inhibitor caffeine …

    loyola-thes Repository record

  9. The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells

    Kandunuri, Kiran KumarLondon Metropolitan University2023

    … and extracts on glucose metabolism in Hep G2 cellular models. The primary objective of this project is to evaluate and compare the metabolic activities of Hep G2 cells after treatment with pure compounds phloretin, ouabain, berberine, and metformin, rebaudioside-A, and extracts of Stevia …

    london-metro Repository record

  10. Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors

    Hsieh, Hui Ju, <p>orcid.org/0000-0002-2583-7670</p>2018

    … Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling pathway controls a transcriptional program of mitotic entry through …

    uthsc Repository record

  11. Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors

    Hsieh, Hui-Ju, <p>orcid.org/0000-0002-2583-7670</p>2018

    … Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling pathway controls a transcriptional program of mitotic entry through …

    uthsc Repository record

  12. G2/M checkpoint associated repression of polo-like kinase-1 mediated by the tumour suppressor, p53

    McKenzie, LynseyUniversity of Dundee2010

    … Kinase-1 (PLK1) is an important mediator of the G2/M phase of the cell cycle that is down-regulated in a DNA damage dependent manner. In cancer cells PLK1 is overexpressed and allows for continued proliferation of the cell by overriding this checkpoint. Here I show that PLK1 is down-regulated in …

    dundee Repository record

  13. Irreducible components of the restricted nilpotent commuting variety of G2, F4 and E6 in good characteristic

    Johnson, Heather, Levy, Paul, Towers, DavidLancaster University2015

    … the irreducible components of gei∩N1 for g = G2 and F4 in good characteristic p. We do the same for g = E6 with the exception of three nilpotent orbits. We use this information to determine the irreducible components of the restricted nilpotent commuting variety C1nil(g)= {(x,y) ∈ N1×N1 : …

    lancaster Repository record

  14. Characterisation of the molecular complexes that regulate the G2/M checkpoint of the eukaryotic cell cycle

    Collings, MelanieResearchSpace@Auckland2009

    … steps, comprising the interphase (G1, S and G2) and the mitotic phase (mitosis and cytokinesis), with two major regulatory checkpoints at G1 and G2. The focus of this research is the G2 checkpoint, which ensures the successful achievement of DNA replication, prior to the initiation of …

    auckland-ms Repository record

  15. The relationship of the RNA synthesized in G2 to mitosis in HeLa cells synchronized by the thymidine block method

    Howze, GwendolynTexas Woman's University1973

    No abstract available

    twu Repository record

  16. Effects of individual fatty acids on cellular lipid synthesis, lipoprotein secretion, and receptor-mediated lipoprotein uptake in Hep-G2 cells

    Dokko, Ryowon ChoueUniversity of Illinois at Urbana-Champaign2011

    Restriction data tranferred 2014-07-01T11:14:52-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission

    uiuc Repository record

  17. Two hole extrusion and the effects of M[subscript g2 Si, Si and Fe on the extrudability of 6xxx series aluminium alloys.

    Markides, Christopher Andrew1999

    kings Repository record

  18. Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)

    Cortis, Judith2012

    … E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus untersucht. ERGEBNISSE: …

    goettingen Repository record

  19. In Vitro Chromosomal Radiosensitivity and Cell Cycle Progression in Cancer Survivors

    Cadwell, KevinUniversity of Cenral Lancashire2009

    … investigation into whether variation in in vitro G2 chromosomal radiosensitivity is related to 02 checkpoint efficacy. A modified version of the 02 chromosomal radiosensitivity assay was validated with samples from staff at Westlakes Research Institute. The standard 02 assay protocol was altered …

    cent-lancashire Repository record

  20. Zellzykluseffekte von Mitomycin C

    Endres, KarlheinzUniversität Würzburg

    … der Populationen während der G0-G1-, G1-, S- und G2-Phasen zu erfassen (Kubbies 1989). Das Ausscheiden von Zellen aus dem Zellzyklus kann dabei über die Akkumulation in den entsprechenden Phasenanteilen des Zellzyklus erfasst werden. Die Induktion von Zellzyklusstörungen erfolgte mit dem …

    wurz-thes Repository record

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