Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"G1 cyclins"”.
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Functional Genomic Approaches to Study Cell Polarity Regulation by G1 Cyclins in Saccharomyces cerevisiae
… the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1-, Cln2-Cdc28 and Pcl1-, Pcl2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, like most genes in S. …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… budding yeast was that cell cycle commitment in G1, at a point called Start, requires growth to a critical cell size. This deterministic model did not address how cell size control can be achieved despite the stochasticity of elementary cellular processes. Furthermore, no clear connection between …
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Insights into the consequences of chromosome gains and losses in S. cerevisiae
… of human health. Here, I have characterized the G1 delay in aneuploid S. cerevisiae. Aneuploid yeast exhibited a growth defect in G1. Additionally, aneuploid cells displayed a cell cycle entry delay due to delayed accumulation of G1 cyclins. Like other cellular stresses, aneuploidy interferes …
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Relating topology and dynamics in cell signaling networks
… G2 arrest, paradoxically through its action on G1 cyclins. This thesis demonstrates that we can quantitatively map the logic of cellular decisions, affording new insight and revealing points of control.