Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 459 for “"G1"”.
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Control of M-G1 phase-specific expression in fission yeast
… with the four main cell cycle transitions; G1-S, S, G2-M and M-G1 phases. Each phase-specific transcriptional wave corresponds to at least one group of co-regulated genes, sharing common cis- and trans- acting elements. The work presented in this thesis delves into the regulatory network …
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Functional Genomic Approaches to Study Cell Polarity Regulation by G1 Cyclins in Saccharomyces cerevisiae
… the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1-, Cln2-Cdc28 and Pcl1-, Pcl2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, like most genes in S. …
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Metabolism and Mammary Transport Mechanism of Immunoglobulins G1 and G2 in the Dairy Cow
Made available in DSpace on 2014-12-14T15:29:40Z (GMT). No. of bitstreams: 1 7709167.pdf: 5217603 bytes, checksum: 5a37b0a56d927b6299d6601e28584fc1 (MD5) Previous issue date: 1976
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Analysis of cyclin-CDK mediated regulation of the G1/S transition in post quiescent murine fibroblasts
… the roles of cyclin E and cyclin A in the G1 to S-phase transition and reconstitute initiation of DNA replication in cyclin depleted nuclei using an in vitro DNA replication system. Using a murine 3T3 fibroblast model, chemical and genetic inhibition of CDK activity was used to evaluate the …
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The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
… through MST2, but paradoxically, promotes G1/S progression through modulation of the ubiquitin ligase SCF-BTrCP. Thus, RASSF1A represents a critical line of defense against tumorigenesis as its loss triggers cell arrest; however, loss of RASSF1A also promotes proliferative signaling events, …
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T-Lymphozyten aus Nabelschnurblut tragen den Killer cell Lektin-like Receptor G1 (KLRG1) : eine phänotypische und funktionelle Charakterisierung
… Expression des "Killer cell Lectin-like Receptor G1" (KLRG1) konnte bei adulten Mäusen und Menschen eine einzigartige Subpopulation von T-Zellen beschrieben werden, die phänotypisch den Effektor- bzw. Gedächtniszellen zuzurechnen sind und ihre Teilungsfähigkeit verloren haben. Überraschenderweise …
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The candidate tumour suppressor, XIAP associated factor 1 (XAF1), directly inhibits XIAP activity and induces G1 phase cell cycle arrest
… of XAF1A in HEL299 cells triggered a G1 cell cycle arrest. This G1 arrest coincides with an increase in p21, but not p53. The ability of XAF1 to block XIAP function and induce cell cycle arrest suggests a role for XAF1 in the control of both apoptosis and cell growth. The coding …
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
… polyteny. It is preceded by the first detectable G1 period in Drosophila embryogenesis and developmentally regulated induction of S phase genes in the pattern of DNA synthesis. My analysis of the regulation of G1-S progression began with a genetic screen for mutations that disrupt the …
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Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds That Induce G1 Cell Cycle Arrest
… cells after causing growth arrest in the G1 phase of the cell cycle. Compounds that induce G1 arrest have potential to avoid many inherent resistances and potentially have a novel macromolecular target since few G1 signaling pathways have been validated as anticancer targets. …
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Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)
… Die quantitativen Proteinexpressionen von den G1-Phase-Proteinen E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl …
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Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.
This thesis aimed to characterise the G1-S phase role of Drosophila Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… normal liver regeneration with slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression of cyclin E1 and prolonged cdk2 kinase activity leading to earlier and sustained DNA synthesis. Higher DNA synthesis in cyclin …
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Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds That Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action
… scaffold was pursued for its ability to induce G1 cell cycle arrest and apoptosis in melanoma cells, a cell type notoriously resistant to several common classes of chemotherapeutics. It was determined that TPMAs act via disrution of normal endoplasmic reticulum function, inducing apoptosis …
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Molecular definition of group 1 innate lymphoid cells in the uterus
Uterine NK cells (uNKs) are group 1 (g1) innate lymphoid cells (ILCs) that have been shown to regulate remodelling of uterine blood vessels, an event necessary to support fetal growth. Recently, other ILCs were identified in the mucosa and wall of the uterus of mice and women, pregnant or not. They …
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Expression und immunmodulatorische Funktion von HLA-G und seinen verkürzten Isoformen in Tumorzellinien
… Neben dem kompletten membranständigen HLA-G1 mit den extrazellulären Domänen a1, a2 und a3 existieren die verkürzten Isoformen HLA-G2 (∆a2), HLA-G3 (∆a2, ∆a3) und HLA-G4 (∆a3). Außerdem wurden die löslichen Isoformen HLA-G5 (HLA-G1s), HLA-G6 (HLA-G2s, ∆a2) und HLA-G7 (HLA-G3s, ∆a2, ∆a3) …
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Funktionelle Charakterisierung und ultrastrukturelle Lokalisierung der Isotypen des Hüllprotein-Komplexes Coatomer
… entdeckt. Es wurden Bindungsstudien mit den g1- und g2-COP appendage Domänen durchgeführt. Appendage Domänen wurden erstmalig bei den a/b-Adaptinen, Bestandteile der Clathrin-Adaptorkomplexe (APs), identifiziert. Neben Aminosäuresequenz-Vergleichen zwischen AP-Komplexen und dem b/d/g/z-COPI …
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Genetic Analysis of Soybean Mosaic Virus Resistance in Soybean
… to the Rsv1 locus, expresses resistance to SMV-G1 and G7 and is derived from Raiden. The other is allelic to the Rsv3 locus, expresses resistance to SMV-G7 but susceptibility to SMV-G1 and is derived from Harosoy. Therefore the Rsv2 locus does not appear to exist in OX670 or its ancestors. The …
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Cell cycle dynamics and the physiology of saxitoxin biosynthesis in Alexandrium fundyense (Dinophyceae)
… of approximately eight to ten hours in early G1. Analysis of the cell cycle dynamics suggests the existence of two transition points: one at the beginning of G1, which is light-dependent and holds the cells in a Go-like period, and a second one at the end of G1, which is size-dependent and …
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Molekulare Mechanismen der Regulation der Glukagon-Gentranskription durch die Pax6-Homöodomäne
… über seine Paired-Domäne an das PISCES-Motiv im G1- und G3-Element des Glukagon-Genpromotors und aktiviert synergistisch die Transkription des Glukagon-Gens. Pax6 besitzt noch eine weitere DNA-Bindedomäne, die Homöodomäne, deren Funktion weitgehend unbekannt ist. Vorangegangene Untersuchungen in …
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Funktionelle Charakterisierung der humanen Polo-Kinase Plk2/Snk im Zell- und Centrosomenzyklus
… die Plk2-Aktivität in HeLa-Zellen in der späten G1-Phase ansteigt und ihr Maximum am G1/S-Übergang erreicht, etwa zum gleichen Zeitpunkt der Aktivierung der Cyclin E/Cdk2-Kinase. Da der Proteingehalt von Plk2 während der gesamten Zeit konstant ist, wird Plk2 wahrscheinlich in jeder G1-Phase durch …
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