Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"G-quadruplex RNA"”.
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The Role of G-Quadruplex RNA Motif in Fragile X Syndrome
… X mental retardation protein (FMRP). As an RNA binding protein, FMRP has been proposed to regulate the transport and translation of specific message RNA (mRNA). It has been reported that FMRP uses its RGG box domain to bind mRNA targets that form a G-quadruplex structure, structure believed …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
… demonstrated their ability to form the desired ternary complexes with tubulin and E3 ligases. This chapter emphasizes a structured and rational approach to PROTAC development, integrating structural insights and cellular studies to enhance drug discovery efforts. The exploration then transitions …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
… induced cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain switch (S) regions in the DNA for CSR. Sequence alignment revealed homology between the AID G4 binding domain and the RNA helicase …
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Identification et caractérisation des G-quadruplexes dans le transcriptome humain
Guanine-rich RNA sequences can fold into a very stable non-canonical tetrahelical structure called G-quadruplex (G4). In RNA, these structures can be associated with several of post-transcriptional roles such as translation, splicing and polyadenylation. However, the assessment and study of G4 …