Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"G-quadruplex"”.
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Exploring genetic interactions with G-quadruplex structures
G-quadruplexes are non-canonical nucleic acid secondary structures of increasing biological and medicinal interest due to their proposed physiological functions in transcription, replication, translation and telomere biology. Aberrant G4 formation and stabilisation have been linked to genome …
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G-quadruplex recognition and isolation with small molecules
… the last few decades. One such structure, the G-quadruplex, has been the focus of an increasing number of scientists as G-quadruplexes are believed to play a role in biological processes such as telomere integrity and gene expression. Their existence in vivo is largely unproven but they have …
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DNA G-quadruplex structures in human cancer cells
… of genetics and diseases. In particular, G-quadruplexes (G4s), four-stranded structures formed in guanine-rich sequences of cellular chromatin, are implicated in transcription, replication and genome stability. G4s may also present new opportunities for targeting in anti-cancer therapeutic …
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Genetic selection of cyclic peptide G-quadruplex ligands
… Indeed, molecular probes that bind the G-quadruplex (G4) nucleic acid structure have been instrumental in demonstrating the existence and biological importance of these non-canonical secondary structures. There is increasing evidence that G4s present new opportunities in treating cancer …
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The Role of G-Quadruplex RNA Motif in Fragile X Syndrome
… box domain to bind mRNA targets that form a G-quadruplex structure, structure believed to be important for FMRP recognition of at least a subclass of its mRNA targets. We have hypothesized that the interaction of FMRP with selected relevant mRNA targets occurs in a G-quadruplex dependent …
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Single-molecule G-quadruplex visualisation in live cells and 3D chromatin
The G-quadruplex (G4) is a secondary DNA structure formed by the self-assembly of guanine nucleotides. Mapping G4 formation in the human genome shows that they are enriched in functionally important regions such as promoters, enhancers, transcription factor and architectural protein binding sites. …
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Investigating the function of DNA G-quadruplex structures in human enhancers
… distinct molecular structures. DNA G-quadruplexes (G4s) are four-stranded DNA three-dimensional (3D) structures, that form in guanine-rich regions of the genome. G4s are enriched at sites of important regulatory potential in diverse genomes, including promoters and enhancers. Enhancers …
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Investigating DNA G-quadruplex structure function through genome and epigenome engineering
… structures, such as four-stranded DNA G-quadruplexes (G4s), in genome function remains a largely unanswered question. G4s are implicated in transcriptional regulation; however, earlier studies are mostly correlative and do not directly address the role of an individual G4 within its …
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Interactions Between Platinum-Intercalator Hybrid-Agents and The Human Telomeric G-Quadruplex
… a non-duplex secondary DNA structure known as G-quadruplex. Because this form of DNA cannot be processed by telomerase, small molecules that induce and/or stabilize the G-quadruplex structure have potential applications in cancer chemotherapy.
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Development of nanobodies as tools to investigate G-quadruplex DNA secondary structures
… alternative secondary structures called G-quadruplexes (G4). G4s are suggested to be involved in key genome functions such as transcription, genome stability and epigenetic regulation, together with numerous connections to cancer biology. The detection G4s in cells has been facilitated by …
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Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA
… on the secondary DNA structures known as G-quadruplex formed in the guanine rich telomeric region. G-quadruplex is formed by stacking of G-quartets (a coplanar cyclic array of four Gs) on top of each other. Its formation is known to inhibit the activity of the reverse transcriptase …
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Mechanical stability evaluation of i-motif and G-quadruplex structures under diverse circumstances
G-quadruplex is the most widely known four-stranded nucleic acid structure which has shown to alter gene regulation both in vitro and in vivo. Under certain conditions, another four-stranded structure, i-motif, is also formed in the strand complementary to the G-quadruplex forming sequence. Recent …
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Characterization of inter-genomic and telomeric G-quadruplex structures through atomic force microscopy
The G-quadruplex DNA structure, a secondary folding motif of DNA, is found throughout the genome. The dynamics of these structures has been seen to affect processes such as telomerase elongation and regulation of gene transcription. Typical investigation techniques require these structures to be …
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Computer-Aided Drug Design of G-quadruplex Structures: Harnessing Polarization for Rational Drug Design
G-quadruplexes (GQs) are noncanonical nucleic acid structures formed by guanine-rich se- quences that adopt stable, planar arrangements of guanines stabilized by Hoogsteen hydro- gen bonding. These structures are found throughout the human genome and in numerous pathogens, including viruses and …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
… DNA repeats (i.e. TTAGGG), also known as G-quadruplexes (G4), as well as in sequences in the promoter and other regulatory regions of genes, especially those involved in cellular proliferation. Small molecules that induce the formation of, and selectively bind to, G4 structures are of …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
… DNA repeats (i.e. TTAGGG), also known as G-quadruplexes (G4), as well as in sequences in the promoter and other regulatory regions of genes, especially those involved in cellular proliferation. Small molecules that induce the formation of, and selectively bind to, G4 structures are of …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
As a promising new target for chemotherapy G-quadruplexes (G4) have drawn great interest from the scientific community. Current chemotherapeutic agents exhibit broad toxicity to patients; G4 has the potential to be selectively targeted by novel chemotherapeutic agents that exhibit toxicity specific …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
As a promising new target for chemotherapy G-quadruplexes (G4) have drawn great interest from the scientific community. Current chemotherapeutic agents exhibit broad toxicity to patients; G4 has the potential to be selectively targeted by novel chemotherapeutic agents that exhibit toxicity specific …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
A G-quadruplex (GQ) is a type of noncanonical nucleic acid structure that can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the …
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