Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"G-protein-coupled receptors (GPCRs)"”.
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The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to …
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Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
Membrane proteins, such as G protein-coupled receptors (GPCRs), and soluble proteins play critical roles in a wide range of physiological and pathological cellular processes. GPCRs constitute the largest family of drug targets. The CXCR4 chemokine receptor, in particular, helps promote HIV entry …
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Characterization of Gf a Drosophila trimeric G protein alpha subunit
… to which they are exposed. Plasma membrane receptors play a key role in the transmission of such signals. G-protein coupled receptors (GPCRs) are the largest class of cell surface receptors that respond to an enormous diversity of extracellular stimuli, and are critical mediators of cellular …
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Resolving Signal Transduction in Complex Biological Environments
Cell surface receptors reside in complex biological environments along with their numerous extracellular ligands to transduce information across the membrane bilayer. These receptors regulate major functions including cell proliferation, facilitation of neuronal transmission, cell growth and …
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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
In the hypothalamus, various G-protein coupled receptors (GPCRs) form part of the regulatory pathways of the hypothalamus-pituitary-gonadal (HPG) axis. The master hormone regulator of the HPG axis is the gonadotropin-releasing hormone (GnRH). Defects in GnRH neuron activity are associated with …
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Engineering spores to display g protein-coupled receptors for directed evolution
… of deleterious substances from the outside. G protein-coupled receptors (GPCRs) are the membrane proteins, which transmit signals across the cell membrane. GPCRs are involved in almost every physiological process, and irregular control leads to pathological conditions. Therefore, they are major …
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Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
… receptor that belongs to the superfamily of G protein-coupled receptors (GPCRs). BLT1 and LTB4 are not only important in physiological processes but also in several pathological conditions such as psoriasis, arthritis and atherosclerosis. Monoclonal antibodies recognizing BLT1 were developed …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the …
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Insight into G Protein-Coupled Receptors through Molecular Dynamics Simulations
… significantly to the understanding of protein-drug recognition, providing detailed information on structural flexibility and conformational changes, the supervised molecular dynamics(SuMD) allows to understand the (un)binding paths differences, and metadynamics (MetaD) enhances the …
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Lipid sensitivity of the GPR132 receptor
The pH sensitive receptors are a group of four phylogenetically related G protein coupled receptors (GPCRs). The prototypical member of this family, GPR68, is activated by low pH extracellular conditions. However, GPR132 does not contain histidine residues at equivalent positions and is likely not …
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Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce biological signals. Although GPCRs represent the largest class of targets for therapeutic agents, ligand-binding sites have been precisely defined for only a small percentage of the …
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The roles of human cytomegalovirus US27 gene product during virus infection
… HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In contrast, the US27 gene product is an orphan with no known chemokine ligands. …
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Post-genomic studies on the neuropeptide signalling system of Juvenile <i>Fasciola hepatica</i>
… also been used to identify muscle-specific G-Protein Coupled Receptors (GPCRs). These transcripts were taken forward into a larger-scale RNA interference (RNAi) screen which revealed a high level of transcript knockdown and a profound growth phenotype for one member of the …
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Duplication is a prominent mechanism of recent gene birth in Caenorhabditis elegans
… C. elegans genes. Additionally, I show that G protein-coupled receptors (GPCRs) have high levels of presence/absence variation (PAV) and discuss the significance of this finding in light of the ecology of this little worm.
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
The underlying mechanisms of protein sorting in polarized epithelial cells are poorly understood. Several studies have determined membrane targeting of G protein-coupled receptors (GPCRs) using epithelial cells such as Madin-Darby canine kidney (MDCK) cells. Polarized epithelial cells are composed …
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Interactive Analysis of Protein Structure and Dynamics
… the structure-function relationship of proteins such as G protein-coupled receptors (GPCRs) requires detailed information on their three-dimensional (3D) structure and dynamics. Recent progress in the structural elucidation of receptor-G protein or -arrestin complexes yields valuable …
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Constitutive activity in orphan G protein coupled receptors
… constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular activation of different G proteins and subsequent second messenger synthesis. These small molecules regulate cellular …
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Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein
… circulatory system attached to Retinol Binding Protein (RBP) and its transport into the cell is mediated by the RBP receptor STRA6. Inside the cell, retinol binds to cellular Retinol Binding Protein (CRBP) and can be converted to retinoic acid, which can then act as a regulator of transcription. …
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Towards an accurate alignment of G-protein-coupled receptors from different classes.
G-protein coupled receptors (GPCRs) are a large and diverse family of cell surface receptors involved in signal transduction. They share a general structure of a seven transmembrane domain, an extracellular N-terminus and an intracellular C-terminus domain responsible for coupling to the G-protein. …
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The methuselah family of g protein coupled receptors
<p>G protein-coupled receptors (GPCRs) are one of the largest class of transmembrane signaling proteins that regulate essential developmental and physiological processes in a cell. GPCR success is illustrated by their abundance across both invertebrate and vertebrate genomes. Phylogenetic analyses …
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