Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"G-protein coupled receptors (GPCR)"”.
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR …
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Phylogenetic Analysis of Human Cytomegalovirus pUS27 and pUS28: Ascertaining an Independent or Linked Evolutionary History
… involves the acquisition of four virally encoded GPCR chemokine receptor homologs, products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …
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Role of interleukin-8 monomer-dimer equilibrium and glycosaminoglycan interactions in neutrophil recruitment
Chemokines are small, soluble secreted proteins that induce cell migration through activation of G Protein Coupled Receptors (GPCR), and also bind extracellular matrix\r\nglycosaminoglycans (GAG) for recruiting target cells. Interleukin-8 (IL-8) is a proinflammatory chemokine, recruits neutrophils …
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MRGX1-TRPAI in inflammatory pain signalling
… 1 (TRPA1). TRPA1 activity can be modulated by G-Protein Coupled Receptors (GPCR), leading to sensitisation and hyperalgesia (enhanced pain sensation), typically seen in inflammatory pain conditions. Human Mas-related G-protein-coupled receptor X1 (MRGX1) is a promising target for pain relief, …
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Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… Ste3p are well-characterized yeast pheromone G-protein Coupled Receptors (GPCR) those are involved in the signaling of mating responses that lead to cell fusion. Their signaling–associated interactions with G-protein/MAPK signal transduction machinery are well established, homologous to those in …
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… CNS is mediated by two different classes of G protein- coupled receptors (GPCR), the D1R-like receptors (D1R and D5R) and D2R- like receptors (D2R, D3R and D4R, Seeman et al., 1994). Among dopamine receptors, the dopamine D3 receptor (D3R) has captured the scientific interest because of its …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… with altered enteroendocrine profiles. G-protein coupled receptors (GPCR)s are considered attractive targets to modulate incretin secretion. The aim of this dissertation was to investigate the contributions of GPCRs to incretin secretion. Receptors of interest were identified based on …
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Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… insulin release for type 2 diabetics. G-protein coupled receptors (GPCR) represent the largest non-antibiotic drug targets and several family members are expressed in beta cells. Regulators of G-protein Signaling (RGS) proteins are feedback regulators of GPCRs. Their expression can be …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… of disease. PGE2 signals via 4 E-prostanoid (EP) receptors, EP1-EP4, all G-protein coupled receptors (GPCR). The EP3 receptor, the most abundant PGE2 receptor in the brain, is unique in that it is alternatively spliced giving rise to species specific isoforms. One of the EP3 receptor isoforms, …
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Studies of Smoothened in Hedgehog Signaling Pathway
… Hh signal transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is still a mystery how Smo transduces graded Hh signal to downstream components. Although Smo shares some structural similarity with G protein coupled receptors (GPCR), there is little evidence that G …
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The regulation of the CAMP signalling pathway in the human pathogenic fungus, Paracoccidioides brasiliensis
… and Walmsley, 2000; Kronstad et al., 1998). G proteins are guanine-nucleotide (GDP or GTP) binding proteins that are generally associated with the cytoplasmic side of the plasma membrane. They receive signals from G protein-coupled receptors (GPCR). Adenylyl cyclase acts downstream of these G …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… increased oxidative stress, and the formation of protein aggregates are believed to be key mediators implicated in ALS pathology. To address this need, new targets may facilitate more effective drug discovery. One target of interest is by modulating the renin-angiotensin system (RAS), mediated by …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… vivo model. Finally, proglucagon mRNA, and the G-protein coupled receptors (GPCR), Free Fatty Acid Receptor FFAR2) and Free Fatty Acid Receptor 3 (FFAR3), were measured. To establish that butyrate increased the glucose transport capacity of the intestine through upregulation of GLUT2, mRNA …
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Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows
… (PMNL) gene expression of fatty acid-sensing G-protein coupled receptors (GPCRs), and 2) evaluate the effect of overfeeding during the dry period on the PMNL transcriptome. In the first study, cows were either 1) retrospectively classified as having high (HI; BCS > 3.75) or low (LO; BCS < 3.25) …
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Régulation du récepteur aux opioïdes de type delta par les protéines Homer1
Compared to other opioid receptors, the delta opioid receptor (DOP), a G proteincoupled receptor (GPCR), is considered a promising therapeutic target for chronic pain management. However, DOP mainly localizes to intracellular compartments whereas its analgesic effects occur when translocated to the …
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Engineering the angiotensin II type 1 receptor for structural studies
G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of …