Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 191 for “"G-protein coupled receptor"”.
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Elucidating the biology of G-protein coupled receptor 35
G-protein coupled receptor 35 (GPR35) is an orphan G-protein coupled receptor which has attracted attention as a coding variant is linked to primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… responses through a number of proton-sensitive receptors including both ion channels and G protein-coupled receptors, many of which are expressed by immune cells and sensory neurones, the principal drivers of inflammation and nociception respectively. While proton-sensitive ion channels, such as …
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Modelling fitness and stability of G protein-coupled receptor variants
G protein-coupled receptors (GPCRs) are the molecular targets of more than a third of approved drugs1 used in a wide variety of diseases2. Protein-altering genetic variants have complex effects on the biophysical and functional properties of GPCRs. Understanding the biophysical and functional …
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Computational and experimental investigation of G protein-coupled receptor signalling mechanisms
G Protein-Coupled Receptors (GPCRs) are 7-transmembrane domain proteins. These receptors translate extracellular stimuli into cellular responses through heterotrimeric G proteins and β-arrestin proteins. These receptors are of considerable therapeutic interest, targeted by over 500 drugs approved …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …
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G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
… pathophysiology. A broad family of transmembrane receptors known as G protein-coupled receptors (GPCRs) has been implicated in various roles of cardiovascular pathophysiology, yet the roles of several specific GPCR subfamilies in CVD pathology remain unclear. In this study, two understudied GPCR …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… SCFAs have been shown to be ligands fortwo G protein-coupled receptors (GPCRs), Gpr41 and Gpr43. We show that Gpr41 is expressed in the intestinal enteroendocrine cells. The localization of Gpr41 to enteroendocrine cells suggests that SCFAs signaling through Gpr41 induces the enteroendocrine …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
<p>G protein-coupled receptors (GPCRs) comprise a large family of related seventransmembrane- helical membrane proteins that bind to specific extracellular ligands, such as hormones or neuromodulators. The active receptor-ligand complex then engages with a heterotrimeric G protein on the …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
In addition to high-affinity IgE receptor (FcεRI), a subtype of mast cells (MCs) found primarily in human skin, expresses a G protein-coupled receptor (GPCR) known as MRGPRX2 (mouse counterpart MrgprB2). Following agonist stimulation, GPCRs couple to G proteins to cause cellular activation but most …
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The interplay of sodium and voltage in the regulation of G-protein coupled receptor signalling
Playing a central role in cell signaling, G-protein coupled receptors (GPCRs) form the largest superfamily of membrane proteins and approximately a third of all drug targets in humans. The membrane potential is one of the defining characteristics of living cells. Recent work has shown that the …
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Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
Dopamine receptors mediate various important neurophysiological functions. At a molecular level, G protein coupling is considered the main activation mechanism for most of the receptor-mediated cellular processes. A number of studies using native tissue have supported the idea that receptors can …
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Normal aging and cognition: System-specific changes to G-protein coupled receptor-mediated signal transduction within the hippocampus
… AND COGNITION: SYSTEM-SPECIFIC CHANGES TO G-PROTEIN COUPLED RECEPTOR-MEDIATED SIGNAL TRANSDUCTION WITHIN THE HIPPOCAMPUS
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the …
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Rhodopsin kinase structure: different nucleotide-binding states and implications for mechanism of activation of a G protein coupled receptor kinase
G protein coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins and downregulation. The desensitization of GPCRs is critical to render cells responsive to further stimuli and if not regulated can result in many …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… interleukin 17 (IL-17) and the proton-sensing G protein-coupled receptor (GPCR) GPR68. In the first part of my research, I identified IL-17 as a pro-nociceptive cytokine. This was based on transcriptomic data showing elevated IL17A expression in colonic biopsies from individuals with IBD and …
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Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae
G-proton coupled receptors (GPCRs) are excellent drug targets that occupy a central position in the physiology of insects and are involved in transmission of signal from the extracellular to the intracellular side of the cell. Adipokinetic hormone receptors (AKHRs) are GPCRs that mediate …
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