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Showing 1 to 4 of 4 for “"G-Quadruplex (GQ)"”.
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Effect of oxidative stress on human telomeric DNA structural dynamics and accessibility
… TTAGGG repeats (ssTEL) that can form into a G-quadruplex (GQ). This guanine-rich sequence is prone to 8-oxoguanine (8OG) damage, which is one of the most common oxidative DNA lesions that can compromise telomere integrity. Here, we use single molecule Förster Resonance Energy Transfer (smFRET) …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
A G-quadruplex (GQ) is a type of noncanonical nucleic acid structure that can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the …
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Information theoretic and machine learning techniques for emerging genomic data analysis
… to form a four-stranded structure called ""G-quadruplex"" (GQ). GQ structures have been proposed to regulate diverse key biological processes including transcription, replication, and translation. I present main factors that lead to GQ formation, and propose highly accurate linear regression …
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Structural characterization of G-Quadruplexes within duplex DNA
The G-Quadruplex (GQ) is a repetitive, guanine rich DNA sequence that occurs throughout the genome. This specific DNA motif is capable of forming an alternative DNA secondary structure similar to a rectangular prism. The most common GQ motif consists of four sets of three guanine bases separated by …