Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"G-CSF"”.
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Regulation of the potential tumorsuppressor gene mad1 by G-CSF
… is that granulocyte colony-stimulating factor (G-CSF) that drives differentiation of granulocytic cells induces mad1 expression. In general, Mad1 is well expressed in a variety of cells undergoing differentiating and in non-cycling terminally differentiated cells. It has been shown that Mad1 …
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The role of the bone marrow niche and G-CSF in osteochondral repair
… agent granulocyte-colony stimulating factor (G-CSF). This cytokine has previously been shown to improve the repair of osteochondral tissues, however, the cellular mechanisms underlying this response are poorly described. This thesis investigates BMSC and HSPC interactions in bone and cartilage …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor function and reducing apoptosis in the brain. Furthermore, G-CSF is shown in the naïve rat to regulate hormones of the HPA axis. Therefore we hypothesized that G-CSF may …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor function and reducing apoptosis in the brain. Furthermore, G-CSF is shown in the naïve rat to regulate hormones of the HPA axis. Therefore we hypothesized that G-CSF may in …
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Molecular and biochemical characterization of suppressor of cytokine signaling-3 (SOCS-3) and SH2-containing phosphatase 1 (SHP-1) in the context of G-CSF) and erythropoietin signaling
… SHP-1 has been demonstrated to be induced by G-CSF in granulocytic differentiation. These observations lead to the assumption that this protein may represent a potential drug target and an inhibitor of this phosphatase would be expected to promote erythropoiesis and granulopoiesis. Thus, SHP-1 …
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Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… Granulocyte-colony stimulating factor: G-CSF), a hematopoietic growth factor, is the most widely-used mobilizing agent clinically. However, the mechanisms by which G-CSF elicits HSPC mobilization are not well-understood. The experiments described herein are directed towards understanding …
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A new insight on direct actions of Granulocyte-Colony Stimulating Factor in the myocardium
… (engl. granulocyte colony- stimulating factor, G-CSF) ist ein bekanntes hämatopoetisches Zytokin, das die Proliferation und Differenzierung neutrophiler Voläuferzellen fördert. Da G-CSF den Verlauf ischämischer Myokardläsionen positiv beeinflussen kann, wurde angenommen, dass dieser Effekt auf der …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… granulocyte colony-stimulating factor (G��CSF) is used clinically to induce neutrophil mobilization from the marrow. This process was previously demonstrated to require the STAT3 transcription factor (signal transducer and activator of transcription 3), the principal signaling molecule …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated with G-CSF (+G-CSF group; n …
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The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… is Granulocyte-colony stimulating factor: G-CSF). G-CSF is widely used clinically and several molecular mechanisms have been implicated as mediating its mobilizing action. However, many questions remain as to the relationship between these various pathways. This work begins by focusing on one …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… the first time, we determined tumor derived G-CSF to play a major role in affecting immune response against breast cancer ATCVs. By using CRISPR/Cas9 genome editing technology, we found that tumor derived G-CSF results in the accumulation of exceptionally high levels of myeloid derived …
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Mechanistic studies on chemical instabilities of recombinant proteins
… 'of methionine residues in a model protein G-CSF (Granulocyte-Colony Stimulating Factor) was studied to address the issue of how protein structure affects its reactivity. Comparative oxidation studies were performed where the kinetics of oxidation of methionine residues by hydrogen peroxide …
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Effect of Advanced Age on the Innate Immune Response to Cutaneous Wound Infection
… either received 3 s.c. injections of 250 pg of G-CSF or saline vehicle. G-CSF treatment in aged mice reduced bacterial colonization and wound size relative to saline controls. This was associated with increased neutrophil accumulation in wounds of aged, G-CSF treated mice at days 3 and 7 following …
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Regulation Of Neutrophil Homeostasis By Chemokines Signaling Through The Cxcr2 And Cxcr4 Receptors
… to granulocyte colony stimulating factor: G-CSF), CXCL2, or Listeria monocytogenes infection are absent or impaired in CXCR4-/- neutrophils, suggesting that disruption of CXCR4 signaling may be a common step mediating neutrophil release. CXCR2-/- neutrophils exhibit abnormal retention in the …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… mediates mechanisms of brain injury and that G-CSF exerts structural and functional protection after neonatal HI.</p> <p>To mimic the clinical features of HI brain injury, neonatal rat pups were subjected to unilateral carotid artery ligation followed by 2 hours of hypoxia (8% O2 at 37°C). We …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… gene do not express detectable levels of the G-CSF receptor and produce no neutrophils. We have recently shown that C/EBPa function is also impaired in acute myeloid leukemias. However, how the transcriptional activity of C/EBPa is regulated both in myelopoiesis and leukemogenesis, is not fully …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… (IFNβ), granulocyte-colony stimulating factor (G-CSF), and osteopontin (OPN) in reducing apoptosis and inflammation following neonatal hypoxic ischemic encephalopathy and have outlined the cellular pathways involved in their abilities to provide neuroprotection. Our work showed that intranasal …
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Stabilisierung von pharmazeutischen Proteinlösungen durch Vakuumtrocknung
… Granulocyten-Kolonie-stimulierender Faktor (G-CSF) wurde im Detail untersucht, und Erklärungshypothesen wurden entwickelt.
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