Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"G protein signaling"”.
-
Dynamic Scaffolding in a G-Protein Signaling Cascade
The file named "mishraprashant.pdf" is the primary dissertation file. Supplemental movie files ("Mishra_Movie_S1.mpg", "Mishra_Movie_S2.mpg") are also available.
-
THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
<p>The R7 regulators of G protein signaling (R7 RGS), namely RGS6, RGS7, RGS9 and RGS11, are expressed in the retina along with its binding partner Gβ5. The RGS9-1 isoform is expressed only in retinal photoreceptors and rate-limits the recovery of rod phototransduction by acting as a member of the …
-
The Role of G-Protein Signaling in Pathogenesis in Cercospora zeae-maydis
… not well understood. In fungi, heterotrimeric G-proteins consist of three subunits (α, β, and γ) and mediate responses to environmental stimuli. They regulate diverse functions, including nutrient detection, virulence, fungal development, conidiation, secondary metabolism, and pathogenesis in …
-
Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
… of GDP from the nucleotide binding pocket of G protein a subunit (Ga) is accelerated by guanine nucleotide exchange factors (GEFs) and inhibited by guanine nucleotide dissociation inhibitors (GDIs). The beta gamma subunit of heterotrimeric G protein and GoLoco motif are GDIs. Activator of G …
-
Structural Basis of GPCR-Transducer Signaling
<p>G protein-coupled receptors (GPCRs) are a class of ubiquitous cell-surface receptors involved in the regulation of virtually every physiological processes. GPCRs typically signal through either G proteins or beta-arrestins (βarrs), each of which activate distinct cellular pathways that leads to …
-
The Role of Phosducin-like Protein and the Cytosolic Chaperonin CCT in G beta gamma dimer Assembly
<p>Phosducin-like protein (PhLP), a G protein beta gamma subunit dimer binder and G protein signaling regulator, was suggested to regulate the activity of cytosolic chaperonin CCT by their high affinity interaction. In the present study, the three-dimensional structure of PhLP:CCT complex has been …
-
Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
… enzymes in the mevalonate pathway, and G-protein Ggamma 1, which is geranylgeranylated, thus representing an endpoint of isoprenoid biosynthesis. These findings reveal a cardial cell-autonomous requirement of Ggamma 1 geranylgeranylation for heart formation and suggest the involvement of …
-
Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… of the Role of RGS7-family Proteins in Mammalian Retina and Vision</p><p>by</p><p>Matthew David Cain</p><p>Doctor of Philosophy in Biology and Biomedical Sciences</p><p>Molecular Cell Biology</p><p>Washington University in St. Louis, 2014</p><p>Professor Kendall J. Blumer, …
-
Ruolo del recettore CB1 cellulare e sub-cellulare in cellule D1-positive dell'Ippocampo nei Processi della Memoria
… point out a crucial role of hippocampal dopamine signaling in the regulation of memory related processes. Furthermore, recent evidence suggests that hippocampal cells expressing dopamine receptors do also posses CB1 receptors. The work presented in this Thesis aims at establishing a functional …
-
No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function
… (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate its function. For example, …
-
Novel Modulation of Adenylyl Cyclase Type 2
… cyclase isoforms are distinctly modulated by G protein subunits and are therefore hypothesized to be uniquely regulated by proteins that influence G protein signaling. Activator of G protein signaling 3 (AGS3) is a G protein modulator that binds Gαi subunits in the GDP-bound state, implicating …
-
RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
… of D2R trafficking by the regulator of G protein signaling, RGS2. Though RGS2 is most commonly associated with termination of GPCR signaling through accelerated GTPase activity, this study reveals a novel role of RGS2 knockdown in the modulation of quinpirole, a D2/D3 agonist, stimulated …
-
The Role of Phosducin-like Protein as a Co-chaperone with the Cytosolic Chaperonin Complex in Assembly of the G Protein βγ Subunit Dimer
<p>Phosducin-like protein (PhLP) has been shown to interact with the cytosolic chaperonin containing TCP-1 (CCT), and the βγ subunit dimer of heterotrimeric G proteins (Gβγ). Here we provide details obtained from cryo-electron microscopic and biochemical studies on the structure of the complex …
-
Primary characterization of genes involved in the colony development of the insect pathogenic fungus Metarhizium anisopliae /
… with high homology to genes encoding known signaling pathway proteins that regulate pathogenesis and/or asexual development in filamentous fungi. Conidial density counts and insect bioassays suggested that a Serine/Threonine protein kinase COTl homolog is not essential for conidiation or …
-
Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… gigas, to nitrate and characterized changes in protein expression, using a gel-based proteomics approach. Of the 642 protein spots detected, we found that 24 proteins (15 identified) changed expression in response to a 6-hour exposure to nitrate concentrations ranging from 0-73 mg/L, values that …
-
Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target
… treatment with BT-11 leads to changes in the signaling receptor and G-protein signaling receptor pathways, pointing to probable mechanisms mediating BT-11 action.</p> <p>I also found that, in the dorsal hippocampus, LANCL2 is present in the intracellular nuclear and cytoplasmic fractions with …
-
Role of Chaperonin CCT in G-protein Biosynthesis
… and function to assist the folding of other proteins. All chaperonins consist of two stacked rings, which come together to form a central cavity where folding can take place. The eukaryotic cytosolic chaperonin containing TCP1 (CCT) is a member of the group II chaperonins, which are defined …
-
EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… Studies were designed to examine the LH-induced signaling pathways that regulate ovarian steroidogenesis, as well as the subsequent role of steroids and their receptors on oocyte and follicle development. Initial work focused on transcriptionindependent, or nongenomic, steroid-induced maturation …
-
Mechanistic and Engineering Studies of LOV Photoreceptors in Yeast
… factor EL222 and the Regulator of G-protein Signaling (RGS) in the fungal membrane associating protein BcLOV4 are both induced by blue-light sensing LOV domains. While previous work has provided the field with a structural characterization of LOV proteins in the dark state, the …
Page 1 of 2