Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Gβγ subunits"”.
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Molecular Study of Gβγ Dependent Breast Cancer Cell Migration and Invasion
… G proteins in the form of Gα-GTP and Gβγ subunits. Recent studies show that expression of Gβγ-sequestering peptide derived from the carboxyl terminus of β-adrenergic receptor kinase (βARKct), attenuates multiple oncogenic pathways, thus suppressing prostate cancer formation and growth. …
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Novel Modulation of Adenylyl Cyclase Type 2
… isoforms are distinctly modulated by G protein subunits and are therefore hypothesized to be uniquely regulated by proteins that influence G protein signaling. Activator of G protein signaling 3 (AGS3) is a G protein modulator that binds Gαi subunits in the GDP-bound state, implicating AGS3 as …
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… pathway. M2Rs also release G protein beta-gamma subunits (Gβγ), which slow heart rate by activating G protein-gated inwardrectifier potassium (GIRK) channels. Interestingly, βARs also release the very same free Gβγ, but GIRK is not activated. The molecular mechanism underlying this specificity is …
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Characterization of Rimonabant effects on G protein activity
… pathways, or if SR acts directly on G protein subunits. For this purpose we investigated the molecular mechanisms of SR on G protein activity in native and recombinant systems by using different experimental approaches (i.e., GTPγS binding, bioluminescence Resonance Energy Transfer (BRET), …