Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Gαs"”.
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Ubiquitination de Gαs, un nouveau mécanisme de la régulation de la signalisation des récepteurs couplés aux protéines G
… à travers la membrane plasmique. La sous-unité Gαs (isoformes longue et courte) active son effecteur principal, l’adénylate cyclase, induisant la production d’adénosines monophosphates cycliques (AMPc), un seconde messager impliqué dans de nombreux processus cellulaires. Son activité repose sur …
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… stimulation led to rapidly increased Gαs and Gαi palmitoylation only in primary cardiomyocytes. The kinetics of palmitoylation was temporally consistent with the downstream production of cAMP and contractile responses. I identified the plasma membrane-localized palmitoyl …
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Maturation of GABAergic signaling during brainstem development
… demonstrieren, dass GABAB Rezeptoren auch mit Gαs Proteinen interagieren und dass diese Kopplung mit fortschreitender Entwicklung nicht mehr zu beobachten war. Die qualitative und quantitative Analyse der Gα Protein Untereinheiten im Hirnstamm der Maus ergab verschiedene Expressionsmuster für …
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Adenylyl Cyclase Type 9: Regulation and Cardiac Function
… kinases do not directly regulate AC9, except Gαs, in vitro. Although AC9 is forskolin insensitive alone, weak activation by forskolin in the presence of Gαs is possible. AC9 shows significant homodimerization and modest heterodimerization with AC5/6, which may account for the conflicting …
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
… we fused the β2AR with its cognate transducers, Gαs and βarr2, using short linkers as a novel approach for restricting the conformation of the receptor and preferentially activating one of its two signaling pathways. We characterized the behavior of our fusion proteins β2AR-Gαs and β2AR-βarr2 in …
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GPCR to Channel Communication in a Membrane Signaling Pathway
… receptors (βARs) and the stimulatory G protein (Gαs) leads to the opening of downstream hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, resulting in an accelerated heart rate. In contrast, activation of M2 muscarinic receptors (M2Rs) and the inhibitory G protein (Gαi) opens G …
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Evaluation of Adipokinetic Hormone Receptor Function Suggests a Single Tissue is Responsible for Starvation Phenotypes in Drosophila.
… these phenotypes. The AKHR can couple to either Gαs or Gαq in heterologous expression systems, but this study is the first example of quantification of AKHR signaling in vivo. Injection of AKH into intact animals causes calcium levels within the fat body to rise, and this response is absent in …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
… NB aggressiveness, and acted as a predominant Gαs-coupled receptor mediating PGE2-initiated cyclic AMP (cAMP) signaling in NB cells with high-risk factors, including chromosome 11q deletion and MYCN amplification. CRISPR/Cas9 induced EP2 knockout blocked the development of NB xenografts in …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… The vasodilatation in response to GαS-coupled receptor stimulation was also enhanced, but the increases in vasoconstrictor mechanisms dominate the physiological phenotype. In addition, VSMCs cultured from shGRK2-knockdown mice demonstrate an altered ERK1/2 and Akt/PKB signaling with …
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Computational and experimental investigation of G protein-coupled receptor signalling mechanisms
… mutations in GNAS, the gene encoding the Gαs protein. These mutations are linked to the rare iiimetabolic disease pseudohypoparathyroidism (PHP) type 1c (PHP1c). The modelling involved abstraction of the experimental system into a model, input of this model into a computational framework …
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… ion channels through the stimulatory G protein (Gαs) pathway. Parasympathetic stimulation slows heart rate through activation of the muscarinic acetylcholine receptor M2 (M2Rs), which inhibits the effect of sympathetic stimulation through the inhibitory G protein (Gαi) pathway. M2Rs also release …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which is a class B G protein-coupled receptor (GPCR), to mediate glucose homeostasis. It does so by promoting glucose stimulated insulin secretion (GSIS) in the pancreatic β cells and inhibiting …