Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Gαo"”.
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
… activation of Gαi/o signaling. Activated Gαi and Gαo were obviously localized in terminal portions of growing neuritis. Here, I study that a crosstalk between Reelin and Gαi/o signaling is involved in neurite formation. Reelin-induced neuritogenesis was suppressed by treatment of PTX and siRNA of …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… (1) there are age-dependent increases only in Gαo levels, (2) Gαi3 and Gαo are not reduced by intra-PVN injection with pertussis toxin, and (3) Gαz proteins are not reduced by 7 or 14 days of fluoxetine treatment. We also have determined that chronic fluoxetine treatment desensitizes 5-HT1A …
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… we found that more Gα subunits (Gαi1/2/3, Gαo and Gαq) were translocated into lipid rafts whereas their effectors such as adenylyl cyclase (AC) and phospholipase Cβ (PLCβ) remained in non-lipid rafts. Importantly, translocation of Gα subunit isoforms between lipid rafts and non-lipid rafts …
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Investigating the Role of the IP₃ Signalling Pathway in RNA Interference in C. elegans
… not result in an enhanced RNAi response. The Gαo/i homologue, GOA-1, was identified as the most likely activator of EGL-8 due to the strongly enhanced RNAi response in goa-1 loss of function mutants in a number of assays. Other Gα subunits and known regulators of GOA-1 and EGL-30 signalling …
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THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
… (DBCs) and that they are involved in the mGluR6/Gαo/TRPM1 pathway, which mediates DBC light responses. The exact role of RGS7 in DBCs has not been unequivocally determined. We have contributed by making a true RGS7 null mouse line and found the RGS7-/- mice are viable and fertile, but have a …
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Characterization of Rimonabant effects on G protein activity
… BRET approach we monitored dissociation between Gαo and Gβγ subunits and their conformational rearrangements before and after GABAB receptors activation. In addition, using the same assay we studied the molecular interaction between D2 receptor and Gαi1 protein subunits (Gαi1-60, Gαi1-91 and …