Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Fyn"”.
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
<p>Fyn, a member of the Src family kinases, is an oncogene in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not …
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
… activation are well described; however, the SFK Fyn is commonly up-regulated at the mRNA level in multiple human cancers, including GBM, where the mode of increased expression is poorly understood. Since activating mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… (p50 and c-Rel).</p><p>We also found that Fyn tyrosine kinase activation was necessary and sufficient for NF-kB activation and PKC-delta repression. In addition, Fyn was over-expressed in human SCCs and HaCaT-Ras cells. Furthermore, activation of PI3K/AKT pathway was necessary and …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… these studies we sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
… investigated in addition to PI3K/MTOR and FYN pathways. We demonstrate for the first time that Fyn plays a critical role in TrkB mediated proliferation in neuroblastoma. Constitutively active and over-expressed Fyn reduced neuroblastoma proliferation, as measured by PCNA expression. …
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Rôles et mécanismes d'action du récepteur AT[indice inférieur 2] de l'angiotensine II d'un modèle cellulaire neuronal au tissu prostatique humain l'importance du contexte
… . De plus, l'expression de la protéine Fyn native (Fyn-WT) augmente à elle seule l'élongation neuritique, alors que l'expression de sa forme dominant-négative (Fyn-DN) inhibe cet effet induit par l'Ang II. Cependant, aucun effet de Fyn-DN n'a été observé sur l'activation des voies de …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… Literature association tools identified Fyn kinase as potential regulator of MAGE. Fyn knockout mice are known to be more sensitive to the sedative-hypnotic properties of ethanol in the loss of righting reflex (LORR) paradigm. Microarray analysis of Fyn knockout mice revealed a …
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Identifikation von Signalweginteraktionspartnern des Zelladhäsionsmoleküls Muc18/MCAM/CD146
… von fak („focal adhesion kinase“) und fyn (eine Proteintyrosinkinase der src-Familie) wurde nicht beobachtet. P130Cas und p105CasL, sowie nck, ein weiteres Adapterprotein, wurden mit Muc18, unabhängig von Muc18-Aktivierung, kopräzipitiert. Fak, fyn und Paxillin konnten nicht …
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Interaction studies of the cellular prion protein
… expressed in yeast cells. The tyrosine kinase Fyn, activated by PrP in neuronal cells, interact directly with PrP in the yeast two-hybrid system whereas LRP failed to interact with Fyn.
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… and current density whereas phosphorylation by Fyn kinase reduced CRMP2 SUMOylation and Nav1.7 current density. Binding to Nav1.7 was decreased following (i) loss of CRMP2 SUMOylation, (ii) loss of CRMP2 phosphorylation by Cdk5, or (iii) gain of CRMP2 phosphorylation by Fyn. Altering CRMP2 …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… activated T cells, our data suggests that the Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 signaling axes cooperate to transactivate icos transcription by acting on two different sites of its promoter. In T cells undergoing differentiation, we found that T-bet in Th1 or GATA-3 in Th2 cells could …
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Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non- Pharmacological Approaches
… role of a potential novel pathological target, Fyn kinase, in the pathophysiology of neurological disease, examine its distribution in key anatomical regions of the PD brain, and evaluate the potential of inhibition of this target for the treatment of cognitive impairment in PD. The second part …
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Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
… expression of the key signaling molecules Syk, Fyn, Akt and Stat5. Mice chronically overexpressing IL-10 had a reduced response to passive systemic anaphylaxis, indicating impaired mast cell activation.Conclusion: Interleukin-10 suppresses mast cell FcεRI expression in vitro and in vivo, and …
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Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
… war bekannt, dass IL-6 die Src-Kinasen Hck, Fyn und Lyn aktiviert. Ziel die-ser Arbeit war es, genauere Erkenntnisse über die genauen Mechanismen dieser Aktivierung zu gewinnen. Mittels Mutationsanalysen wurde eine „saure Domäne“ zwischen den Aminosäu-ren 771 und 811 von gp130 als …
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A study of keratinocyte differentiation and adhesion in vitro
… expressed members of this family, c-Src, Fyn and c-Yes were localised to the cadherin-mediated adhesions formed in response to high extracellular calcium. Treating adherent keratinocytes maintained in low extracellular calcium with a specific Src kinase inhibitor, PD162531, induced the …
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Development and Application of 19F NMR of Proteins
… were developed and evaluated in two systems, Fyn SH3 and calmodulin, labeled with 3-fluorotyrosine. Paramagnetic effects from dissolved oxygen, solvent isotope shifts from deuterium oxide, and 1H-19F NOEs were each sufficient in establishing relative solvent exposure, while the combination of …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
… cells and <em>src-/-</em>,<em> yes-/-</em>,<em> fyn-/-</em> mouse embryo fibroblasts and that increased Yes expression was directly responsible for increased migration of the selected migratory variants. Using shRNA plasmids directing knockdown of Yes, I further demonstrated that silencing Yes …
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
… comparisons revealed that vertebrate Src and Fyn group together, suggesting that they share a common ancestor with one of the two invertebrate SFK. Finally, I developed a novel proteomic approach to identify targets of Src tyrosine kinase signaling as part of a long term goal to understand the …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… associates via its NTD with the Src kinase Fyn, and via its C1 domain with the NR2A subunit of the NMDA receptor. Further experiments explored a1-chimaerin effects on EphA4 and NMDA receptor cell surface expression, as well as binding to other putative partners – including the adaptor …
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Costimulatory function of CD44
… subfamily, and src-family kinases, two of which, fyn and lck, were found to be associated with CD44. By cross-linkage of CD44 these kinases were redistributed into so called lipid rafts. It is supposed that for T cell activation a relocation of the TCR/CD3 complex into the same membrane …
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