Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Fxr"”.
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
Farnesoid X receptor (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in …
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Role of Src phosphorylation of FXR in bile acid regulation
… be tightly regulated. The farnesoid X receptor (FXR) is the primary bile acid nuclear receptor and acts as the master regulator of bile acid homeostasis, preventing liver damage caused by bile acid accumulation. FXR does this by regulating the expression of many target genes in the gut and liver …
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Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… to metabolic disease. Farnesoid X Receptor (FXR) which is known as a primary bile acid nuclear receptor plays important roles for maintaining levels of metabolites like triglycerides, fatty acids and glucose by regulating its targets genes in liver. Over the past decades, compelling studies …
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Účinek agonistů nukleárních receptorů (FXR, CAR, aj.) na játra a hepatocyty za různých stavů
Effects of nuclear receptor agonists (e.g., FXR, CAR) on the liver and hepatocytes in vivo and in vitro across diverse physiological and pathological conditions Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a substantial proportion of the global population, while …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… the function role of Farnesoid X receptor (FXR) and microRNA-34 (miR-34a), as key transcriptional and post-transcriptional regulators respectively, in maintaining metabolic hemostasis and energy balance. Nuclear receptors (NRs) are lipophilic ligand-dependent transcriptional factors that …
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Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
… on studying the role of two nuclear receptors, FXR and SHP in maintaining liver function. Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are well-known regulators of glucose, fat and bile acid homeostasis. Here, I uncover novel roles for FXR-SHP axis not only in the liver but …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… orphan nuclear receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile acid homeostasis by suppressing the …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… receptor, also known as farnesoid X receptor (FXR), is essential for feedback regulation of bile acid synthesis. Bile acids are required for the proper absorption of dietary lipids, including fat-soluble vitamins; however, some bacterial metabolites of bile acids have been shown to promote …
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The role of microRNA-802 regulated by the nuclear receptor FXR-SHP cascade in obesity and non-alcoholic fatty liver disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism
… for this altered bile acid homeostasis, Osta-Fxr double null mice were generated and studied. Inactivation of Ostalpha was associated with significant increases in small bowel length, small bowel mass predominantly in ileum, villus width and crypt depth, and villus epithelial cell number. Fxr …
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Nuclear receptor co-repressor actions in bladder cancer
… expression of VDR and Farnesoid-X-receptor (FXR) protein is demonstrated along with relative mRNA expression of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is over-expressed in RT-112 (1.6 fold) and EJ-28 cells (2.6 fold). This correlates …
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Forward genetic analysis of cellulose biosynthesis inhibitor resistance and wall hydrolysis sensitivity.
… of resistance to isoxaben (ixr) or flupoxam (fxr) were attributed to single amino acid substitutions in primary wall CESAs. Twelve novel resistance alleles were isolated and no cross-resistance was observed. Point mutations were mostly clustered around the C-terminal regions of CESA1 and …
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The development of a mouse model of post-bariatric hyperinsulinemic hypoglycemia
… Mice were treated with the Farnesoid X Receptor (FXR) agonist, fexaramine (Fex), or vehicle for 5 days before undergoing a glucose tolerance test (GTT). Mice were sacrificed with tissues collected immediately thereafter. PCR was performed to quantify expression of FXR target genes. A separate …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… expression. I identify the farnesoid X receptor (FXR) as a direct regulator of ACE2 transcription in multiple COVID19- affected tissues, including the gastrointestinal and respiratory systems. I use this knowledge to optimise current experimental models for SARS-CoV-2 infection and I demonstrate …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… nuclear hormone receptor, farnesoid x receptor (FXR), thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription factor regulating lipogenic gene …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… androstane receptor (CAR), farnesoid X receptor (FXR), and hepatic nuclear factor 4a (HNF4alpha). Our study revealed lower gene expression of MDR1/P-gp and MRP2 in the early infant period of development. We also identified a lower protein expression of MRP2 in the early infant period. For the …
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
… hydrophobicity and reduced farnesoid X receptor (FXR) affinity. Accordingly, RNAseq analysis revealed a decrease in the mRNA levels of key antioxidant and FXR target genes in the ileum. Although caecal microbiome analysis showed no change in total phylum bacterial counts and key markers of …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… receptor α and farnesoid X receptor (FXR). However, farnesol’s effects on human hepatic lipid metabolism are currently unknown. The objective of this study is to evaluate how farnesol treatment would affect hepatic lipid accumulation and metabolism in a cellular model of human hepatic …
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Characterization and transcriptomic profiling of Arabidopsis thaliana under cellulose biosynthesis inhibitor treatment
… biosynthetic process. Using flupoxam resistant (fxr) and isoxaben resistant (ixr) mutants, we characterized their response to our novel CBIs. Root length clustering showed similar responses and cross-resistance patterns based on mutation location. A 3-D homology protein model of the cellulose …
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