Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Fusogenic Liposomes"”.
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
… delivered into HCT 116 by encapsulation within fusogenic liposomes. In Chapter 7, a peptide segment of a c-Myc inhibitor was grafted into a CTPR scaffold, and also engineered as a chemically stapled peptide. Preliminary pull-down experiments suggested that the stapled peptide bound to c-Myc in …
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Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
… pathway upon delivery by encapsulation in fusogenic liposomes. Lastly, hetero-bifunctional constructs were generated by grafting two different binding sequences onto the CTPR scaffold, and a preliminary analysis of their activities was performed. In conclusion, these results point to the …
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Design and Evaluation of Nanoparticle Systems for Bacterial Targeting
… the design of two NP systems: 1) cationic fusogenic liposomes (cFLs) and 2) metal-organic frameworks (MOFs) for bacterial targeting, with a focus on evaluating their molecular interactions with bacterial envelopes using super-resolution microscopy. cFLs, lipid-based NPs engineered to fuse …