Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Fusobacterium nucleatum"”.
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Studies on the stress response in Fusobacterium nucleatum.
Fusobacterium nucleatum is a saccharolytic Gram-negative anaerobic organism belonging to the so-called ‘orange complex’ which is believed to play an important role in the microbial succession associated with the pathogenesis of periodontal disease. Its genome contains niche-specific genes shared …
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The Role of Fusobacterium nucleatum in the Tumor Microenvironment
… investigate the role of an emerging oncomicrobe, Fusobacterium nucleatum, in the tumor microenvironment (TME). F. nucleatum is a Gram-negative, anaerobic bacterium that is normally found within the oral cavity. However, its selective enrichment in CRC and PDAC tumors is correlated with poor …
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
Fusobacterium nucleatum is a Gram-negative bacterium that serves as a bridging organism in polymicrobial biofilms within the oral cavity. Although the bacterium is abundant in healthy gingival tissue, recent studies have found that F. nucleatum is associated with a wide-spectrum of human diseases …
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Protein expression in Fusobacterium nucleatum ATCC 10953 biofilm cells induced by an alkaline environment.
Fusobacterium nucleatum is a Gram negative anaerobic bacterium, frequently isolated from both healthy and diseased dental plaque and has been implicated in the aetiology of periodontal diseases. Studies have shown that this organism increases in number and proportion in diseased periodontal pockets …
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Expanding the Genetic Toolkit of Fusobacterium nucleatum by Generation of Fully-Sequenced Genomes and Discovery of Natural Competence
… microbiome that has garnered such attention is Fusobacterium nucleatum, a Gram-negative, anaerobic bacterium, that normally inhabits the human oral cavity. Interestingly, F. nucleatum is highly invasive into surrounding cells and tissues of the periodontal pocket (below the gymline) and capable …
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Laying the Genetic and Molecular Foundation for the Study of Fusobacterium Nucleatum in Relation to Human Health and Disease
Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that is a member of the human oral microbiota. Although it is a normal resident of the mouth, it is associated with a number of human diseases including: sepsis, inflammatory bowel disease (IBD), and colorectal cancer (CRC). Despite …
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Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer
… Galvan Advisory Professor: Angela H. Ting, Ph.D. Fusobacterium nucleatum animalis (Fna) is found in the human oral cavity and gut. A distinct clade of Fna is primarily enriched in the tumor microenvironment (TME) and within colorectal cancer (CRC) cells. This clade DNA methylation pattern is …
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Εντερικό μικροβίωμα: Ο ρόλος του στην καρκινογένεση και οι επιπτώσεις στη χειρουργική του παχέος εντέρου
… και αύξηση παθογόνων στελεχών όπως το Fusobacterium nucleatum και το Bacteroides fragilis, τα οποία προάγουν την καρκινογένεση μέσω χρόνιας φλεγμονής, ενεργοποίησης του μονοπατιού Wnt/β-κατενίνης, παραγωγής γενοτοξινών και ανοσολογικής διαφυγής. Στα πλαίσια της χειρουργικής ογκολογίας, …
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Qualitative und quantitative Analyse von parodontopathogenen Mikroorganismen bei Patienten mit koronaren Herzkrankheiten
… nachgewiesen. Prevotella intermedia, Fusobacterium nucleatum und Tanerella forsythensis waren bei über 70% dieser Probandengruppe vorhanden. Der Spirochät Treponema denticola wurde sogar bei über 80 % der Patienten detektiert. Ferner konnte auf einem Selektionsnährmedium Actinobacillus …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… was induced by CRC-associated microbiota and Fusobacterium nucleatum (Fn). Priming with Fn did not influence the killing capabilities of iNKT cells in vitro, while it induced their expression of GM-CSF, IL17 and neutrophil-chemotactic genes. The existence of an iNKT-neutrophil crosstalk was …
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Peptide hydrogels as novel scaffolds for dental pulp cell culture
… Staphylococcus aureus, Enterococcus faecalis and Fusobacterium nucleatum. <br/><br/>In conclusion, peptide hydrogels may have potential for future use in regenerative endodontic therapies based on their biocompatibility, with human dental pulp cells, their ability to secrete angiogenic and …
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The systemic inflammatory response to dental plaque
… between circulating human neutrophils and Fusobacterium nucleatum. Methods: For both clinical studies, healthy adults, aged 18-31 years, were recruited. In the first study, black and white, males and females participated in a 21-day EGM; in the second study, white adults participated in a …
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Το μικροβίωμα του παχέος εντέρου στην καρκινογέννεση. Κλινική αξία στην πρόγνωση και θεραπεία της νόσου
… coli (pks+), το Enterococcus faecalis και το Fusobacterium nucleatum, εμπλέκονται ενεργά στην καρκινογένεση μέσω μηχανισμών όπως η παραγωγή γενοτοξινών, η ενεργοποίηση φλεγμονωδών μονοπατιών (NF-κB, STAT3), η διαταραχή του εντερικού φραγμού και η ανοσοδιαφυγή. Τα θεωρητικά μοντέλα …
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The Role of Gram - Negative Anaerobes in Hidradenitis Suppurativa
… (GNA) such as Prevotella, Porphyromonas, and Fusobacterium are commonly identified in HS lesions, and their prevalence in lesions is associated with HS disease severity. Additionally, newly epithelialized structures called "dermal tunnels" are found in severe disease and are associated with …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… by elucidating the specific contributions of Fusobacterium nucleatum (F. nucleatum) to pancreatic cancer pathogenesis and developing a novel therapeutic approach for eliminating these intracellular bacteria; and second, by analyzing how a stromal-targeted therapy directed at hyaluronic acid …
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Decoding novel virulence strategies in Fusobacterium invasion and survival
Fusobacterium nucleatum is an anaerobic, Gram-negative, oral bacterium that disseminates from the mouth, and contributes to preterm birth, tissue infections, and acceleration of multiple cancers including colorectal and pancreatic. It is well-established that most Fusobacterium species exhibit …
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Artificial teeth : dental biofilm analysis on a chip
… of two key dental bacteria, Streptococci sp. and Fusobacterium nucleatum, in the biofilm under different microenvironments, including their growth under different gas conditions and their adherence properties with different sucrose concentrations. This work demonstrates a successful application of …
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Differential Stimulation of Monocytes to Secrete Secretory Leukocyte Protease Inhibitor by Lipopolysaccharide of Periodontal Pathogens
… <em>Prevotella denticola</em>, and <em>Fusobacterium nucleatum</em> were isolated for this study under identical conditions. Cultured human monocytic cells were incubated with LPS and the amounts of SLPI secreted were measured. Monocytic cells were also incubated with endogenous SLPI …
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Impact of the gut microbiota on DNA methylation in colorectal cancer
… Bacteroides fragilis, Escherichia coli, Fusobacterium nucleatum, and Klebsiella pneumoniae. Notably, they exhibited higher enrichment in CIMP-Positive tumor samples, except for E. coli. This analysis also identified a group of samples referred to as bacterial "Superhigh," characterized by …
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KINETICS AND PROTEOLYTIC SIGNATURES OF HISTATIN 5 DEGRADATION IN SALIVA AND GINGIVAL CREVICULAR FLUID IN PERIODONTAL HEALTH AND GINGIVITIS
… Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Streptococcus. mutans) capable of degrading histatin 5 in vitro and characterizing the resulting peptide fragments; (2) comparing histatin 5 degradation rate in pooled saliva (whole saliva supernatant (WSS)) and GCF from …
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