Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Fusobacterium"”.
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Genomics and virulence factors of Fusobacterium necrophorum
Fusobacterium necrophorum, a Gram negative, anaerobic bacterium, is a common cause of acute pharyngitis and tonsillitis and a rare cause of more severe infections of the head and neck. At the beginning of the project, there was no available genome sequence for F. necrophorum. The aim of this …
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Studies on the stress response in Fusobacterium nucleatum.
Fusobacterium nucleatum is a saccharolytic Gram-negative anaerobic organism belonging to the so-called ‘orange complex’ which is believed to play an important role in the microbial succession associated with the pathogenesis of periodontal disease. Its genome contains niche-specific genes shared …
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Mechanistic studies of Fusobacterium genetic and defense systems
Fusobacterium are Gram-negative anaerobic bacteria that colonize a variety of eukaryotes including cattle and humans. In humans, Fusobacterium coordinates the central architecture of the oral biofilm by expressing an abundance of outer membrane adhesins that mediate bridging between early and late …
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The Role of Fusobacterium nucleatum in the Tumor Microenvironment
… investigate the role of an emerging oncomicrobe, Fusobacterium nucleatum, in the tumor microenvironment (TME). F. nucleatum is a Gram-negative, anaerobic bacterium that is normally found within the oral cavity. However, its selective enrichment in CRC and PDAC tumors is correlated with poor …
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Decoding novel virulence strategies in Fusobacterium invasion and survival
Fusobacterium nucleatum is an anaerobic, Gram-negative, oral bacterium that disseminates from the mouth, and contributes to preterm birth, tissue infections, and acceleration of multiple cancers including colorectal and pancreatic. It is well-established that most Fusobacterium species exhibit …
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
Fusobacterium nucleatum is a Gram-negative bacterium that serves as a bridging organism in polymicrobial biofilms within the oral cavity. Although the bacterium is abundant in healthy gingival tissue, recent studies have found that F. nucleatum is associated with a wide-spectrum of human diseases …
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"A syndrome so characteristic" Molecular and clinical studies of Fusobacterium necrophorum and Lemierre's syndrome
Lemierre’s syndrome is caused by Fusobacterium necrophorum and involves tonsillitis, jugular vein thrombophlebitis and septic pulmonary emboli. The first studies underlying this thesis focused on bacterial interaction with coagulation. The contact system initiates the intrinsic pathway of …
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Protein expression in Fusobacterium nucleatum ATCC 10953 biofilm cells induced by an alkaline environment.
Fusobacterium nucleatum is a Gram negative anaerobic bacterium, frequently isolated from both healthy and diseased dental plaque and has been implicated in the aetiology of periodontal diseases. Studies have shown that this organism increases in number and proportion in diseased periodontal pockets …
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Understanding the role of different strain types of Fusobacterium necrophorum: biofilms, glycans and metabolic pathways
Fusobacterium necrophorum an obligate Gram-negative anaerobe has been implicated in the cause of persistent severe throat infections and the systemic life-threatening Lemierre’s syndrome; a potentially fatal periodontal disease, which results in abscess formation in the tonsils. The use of …
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Expanding the Genetic Toolkit of Fusobacterium nucleatum by Generation of Fully-Sequenced Genomes and Discovery of Natural Competence
… microbiome that has garnered such attention is Fusobacterium nucleatum, a Gram-negative, anaerobic bacterium, that normally inhabits the human oral cavity. Interestingly, F. nucleatum is highly invasive into surrounding cells and tissues of the periodontal pocket (below the gymline) and capable …
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Laying the Genetic and Molecular Foundation for the Study of Fusobacterium Nucleatum in Relation to Human Health and Disease
Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that is a member of the human oral microbiota. Although it is a normal resident of the mouth, it is associated with a number of human diseases including: sepsis, inflammatory bowel disease (IBD), and colorectal cancer (CRC). Despite …
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Biofilm-derived Small Molecules Released from Mixed-species Cultures of Fusobacterium necrophorum and Porphyromonas levii Inhibit Bovine Neutrophil Functional Responses
… infections in cattle, humans, and other animals. Fusobacterium necrophorum and Porphyromonas levii are two species of anaerobic, Gram-negative, opportunistic pathogens that have been described as etiological agents in a variety of necrotic, recalcitrant infections. With antimicrobial resistance on …
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The Role of Gram - Negative Anaerobes in Hidradenitis Suppurativa
… (GNA) such as Prevotella, Porphyromonas, and Fusobacterium are commonly identified in HS lesions, and their prevalence in lesions is associated with HS disease severity. Additionally, newly epithelialized structures called "dermal tunnels" are found in severe disease and are associated with …
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ADP-Heptose and Nucleotide Enhancers Drive Fusobacteria-Induced Inflammation
… diseases and cancers. I found that <em>Fusobacterium</em> <em>nucleatum</em> secretes pathogen-associated molecular pattern ADP-heptose and ribonucleotides that together, but not individually, strongly induced NF-<em>κ</em>B signaling as well as the expression of inflammation and cancer …
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Neutrophil Responses to Mixed-Species Anaerobic Biofilms
… composed of two opportunistic pathogens, Fusobacterium necrophorum and Porphyromonas levii and measure neutrophil responses. Neutrophils are a vital component of the innate immune system and the results show that neutrophils exposed to mixed-species planktonic bacteria exhibit a more …
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The use of page and gas chromatography of cellular fatty for the rapid identification of Fusobacteria and Capnocytophaga
… of anaerobic bacteria. Species of <u>Fusobacterium</u> and <u>Capnocytophaga</u> were analyzed to determine the identification accuracy of each system. The electrophoretic patterns of soluble cellular proteins and the cellular fatty acid patterns determined by gas chromatography were …
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Impact of the gut microbiota on DNA methylation in colorectal cancer
… Bacteroides fragilis, Escherichia coli, Fusobacterium nucleatum, and Klebsiella pneumoniae. Notably, they exhibited higher enrichment in CIMP-Positive tumor samples, except for E. coli. This analysis also identified a group of samples referred to as bacterial "Superhigh," characterized by …
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Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer
… Galvan Advisory Professor: Angela H. Ting, Ph.D. Fusobacterium nucleatum animalis (Fna) is found in the human oral cavity and gut. A distinct clade of Fna is primarily enriched in the tumor microenvironment (TME) and within colorectal cancer (CRC) cells. This clade DNA methylation pattern is …
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Εντερικό μικροβίωμα: Ο ρόλος του στην καρκινογένεση και οι επιπτώσεις στη χειρουργική του παχέος εντέρου
… και αύξηση παθογόνων στελεχών όπως το Fusobacterium nucleatum και το Bacteroides fragilis, τα οποία προάγουν την καρκινογένεση μέσω χρόνιας φλεγμονής, ενεργοποίησης του μονοπατιού Wnt/β-κατενίνης, παραγωγής γενοτοξινών και ανοσολογικής διαφυγής. Στα πλαίσια της χειρουργικής ογκολογίας, …
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The aetiology and pathogenesis of tropical ulcer
… The local host response to an infection with a Fusobacterium species was assessed by the number of antibody secreting B-lymphocytes at the site of the ulcers. These parameters may play a role in the localisation of the ulcers and account for recurrent infections.
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