Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"Fusions"”.
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Fusions of association schemes
… schemes and classify them based on their fusions. It can be observed from literature that the nonexistence of nontrivial fusions is a rare phenomenon and this is the motivation behind this thesis. An association scheme, A, is said to be fusion-primitive if there does not exist any …
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Anàlisi econòmica de la plaça financera andorrana: possibles fusions bancàries
El meu treball d'anàlisi i investigació vol aclarir si la fusió és l'única alternativa inevitable per assegurar la viabilitat dels grans bancs andorrans. El sector financer del Principat es troba en una situació plena d'incerteses i indecisions i vull conèixer de primera mà les diferents posicions …
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Protein glycosylation by NleB and the secretion of therapeutic nanobody fusions
… T3SS was created to secrete the nanobody fusions, and in vivo analyses before and after precipitation were completed using C. rodentium and E. coli. Nanobodies fused with effector signal sequences upstream from the camelid signal sequences were expressed, but not secreted through the T3SS. …
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Identification and functional characterisation of gene fusions in human cancer cell lines
… have accelerated the rate at which novel gene fusions are discovered. The discovery of gene fusions such as EML4-ALK in lung cancer and BCR-ABL1 in chronic myeloid leukaemia have already led to changes in clinical care. However, important questions remain about the role of gene fusions in …
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Plant-derived Murine IL-12 and Ricin B-Murine IL-12 Fusions
… transgenic plants producing RTB:IL-12 fusions were generated and characterized. Our results demonstrated that RTB fused to the carboxyl-terminus of IL-12 maintained full lectin activity and IL-12 bioactivity. RTB fused to the amino-terminus of IL-12 did not show lectin activity due to …
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The construction and testing of maize transcriptional fusions in yeast (Saccharomyces cerevisiae)
… study was to construct and test transcriptional fusions of zein promoters and a yeast reporter gene that will serve as part of a two plasmid system that will allow for the identification of maize transcriptional regulators of zein genes. Zein genes are expressed coordinately and tempO~ly during …
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Functional studies of selected actin binding proteins by point mutations and GFP fusions
Profilin is an ubiquitous cytoskeletal protein whose function is fundamental to the maintenance of normal cellular physiology. Site-directed mutagenesis of profilin II from Dictyostelium discoideum by PCR resulted in the point mutations W3N and K114E, whereby the W3N profilin is no longer able to …
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Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… has focused on the design of antibody-cytokine fusions (immunocytokines) directed against stromal components of the tumor using the F8 and L19 antibodies recognizing splice variants of fibronectin. Immunocytokines have proven to preferentially localize at the site of disease for long periods of …
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Characterization of protein secretion in Mycobacterium leprae using phoA fusions in Escherichia coli and Mycobacterium smegmatis
Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
Autologous bone marrow grafting has been shown to aid in the healing of bone defects since the 1950s. Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large …
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A Systems Biology Approach to Characterizing Gene Fusion Pathways in Cancer
Gene fusions have long been known to drive cancer. Initial discovery of gene fusions was opportunistic, and functional assessment was done individually and experimentally. There is no comprehensive systems biology approach to understanding the impact of gene fusions on the signaling networks within …
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Characterization of the expression patterns of <i>CELLULOSE SYNTHASE-LIKE A (CSLA)</i> genes in <i>arabidopsis thaliana</i> using reporter promoter-fusions and immunolocalization
… Arabidopsis plants harboring promoter-<i>GUS</i> fusions at various phases of growth and development was conducted to examine the expression patterns of all nine <i>CSLA</i> genes. The expression patterns observed were largely overlapping, supporting the functional redundancy hypothesis. Some …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… B/myeloid mixed phenotype acute leukemia. These fusions juxtapose full-length ZNF384 to the N terminal portion of a diverse range of partners, most often, transcription factors or epigenetic modifiers. It has been shown that ZNF384-rearranged tumors have a distinct gene expression profile that is …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
Receptor tyrosine kinase (RTK) fusions are a large class of oncoproteins found in ~5% of cancers. Despite development of targeted therapies for cancers driven by fusion oncogenes, drug resistance remains a significant challenge, in part because we still lack a clear understanding of the broader …
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Molecular Mechanisms of C11orf95 translocations in cancer.
… chromosome translocations that produce oncogenic fusions are a prime example of practical therapeutic targets translating into clinical successes. We have previously described the genetic driver of supratentorial (forebrain) ependymomas as translocations of the C11orf95 gene of unknown function …
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NOVEL THERAPEUTIC STRATEGIES IN LUNG CANCERSTRONG BIOLOGICAL BIAS FOR ALK INTRON 19 BREAKPOINTS IN NON-SMALL LUNG CANCER
… oncogenic drivers, including various oncogenic fusions, have been detected in non-small cell lung cancer (NSCLC) paving the way to targeted therapy with tyrosine kinase inhibitors. EML4-ALK translocations are detected in 4-8 % of NSCLC and define a specific subtype of oncogene-driven lung …
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