Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Fusion oncoprotein"”.
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. However, the mechanism for its radiosensitivity is unknown. In order to further understand the biological …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… of senescence induction by RUNX1 and its fusion derived leukaemogenic oncoproteins in primary fibroblasts. My work showed that RUNX1 induces a strong senescence-like response in murine and human primary fibroblasts that requires intact DNA binding, CBFB interaction and C-terminal …
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DEFINING THE ROLE OF THE PCGF3-CONTAINING POLYCOMB REPRESSIVE COMPLEX 1 IN SYNOVIAL SARCOMA
… due to its rarity and therapeutic options. The fusion protein SS18-SSX, found in over 95% of cases, is considered the primary oncogenic driver, disrupting BAF complexes and redirecting them to Polycomb repressive domains, thus activating them. This mislocalization depends on the higher affinity …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… acute leukemias in infants. We expressed MLL-AF9 fusion oncoprotein in WT and S6K1-/- hematopoietic stem and progenitor cells (HSC/Ps) and performed serial transplantation. Upon secondary transplantation, recipients of S6K1 deficient AML cells survived significantly longer compared to controls. …
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A CORRELATIVE CRYO-ELECTRON TOMOGRAPHY APPROACH TO STUDY BRD4-NUT CHROMATIN CONDENSATES ACROSS SCALES
… One example is NUT carcinoma, in which the fusion oncoprotein BRD4-NUT leads to aberrant chromosomal megadomains with liquid-like behavior. While biochemical and genomic studies have investigated the condensation mechanisms and molecular functions of these BMCs, their architecture remains …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… B/myeloid mixed phenotype acute leukemia. These fusions juxtapose full-length ZNF384 to the N terminal portion of a diverse range of partners, most often, transcription factors or epigenetic modifiers. It has been shown that ZNF384-rearranged tumors have a distinct gene expression profile that is …