Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Fusion inhibitor"”.
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A Novel Gene Therapy Approach Based on Secreted Antiviral Proteins for the Control of HIV Replication
… commonly CCR5 or CXCR4). Protein-based HIV entry inhibitors are highly effective in protecting cells from infection. However, their clinical application is limited because their use requires the frequent injection of highly purified proteins. This study focuses on the development of a gene therapy …
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Roles of proteasome, arachidonic acid, and oxytocin in bovine myoblast proliferation and differentiation
… myoblast proliferation, differentiation, and fusion. Three studies were conducted during this project. The objective of the first study was to determine the effect of oxytocin (OXT) on myoblast proliferation, differentiation and fusion. Treating primary bovine myoblasts in culture with 10 nM …
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Molecular analysis of vesicle biogenesis during autophagy
… NV-junctions requires at least three membrane fusion events. Krick et al. reported that the standard homotypic vacuolar fusion machinery is not required for the formation of PMN vesicles. This study indicates the requirement of Cdc48 and its major substrate-recruiting factor Shp1 for efficient …
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Characterisation of functional properties of Envelopes of highly neutralisation resistant HIV-1 isolates
… relationship between susceptibility to the entry inhibitors Maraviroc and PSC RANTES (CCR5 antagonists) and the fusion inhibitor T20 and resistance, indicating that neutralisation resistance did not alter inhibitor target sites. Based on our findings, it is clear that reduced entry efficiency does …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
Crimean-Congo hemorrhagic fever (CCHF) is one of the world’s most medically relevant tick-borne viral diseases. The CCHF virus (CCHFV) is transmitted in seasonal cycles among ticks and animals and is endemic to the Eastern hemisphere. Severe disease may develop with outbreak case fatality rates up …
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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?
… of variants to a range of entry and other inhibitors in order to explore possible changes in function that may arise when viral variants grow in the shifted selective milieu of the genital tract. We further hypothesized that this change of selective milieu as HIV-1 moves from blood into the …