Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Fused in sarcoma"”.
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Characterization of the Roles of Intrinsically Disordered Regions from RNA-Binding Proteins in Phase Separation
… through compartmentalization. While many intracellular compartments are enclosed by membranes, others are not. Messenger ribonucleoprotein (mRNP) granules are membrane-less organelles that enrich RNA and RNA-binding proteins containing intrinsically disordered regions (IDRs). I demonstrate …
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Kap-[beta]2 Recognition of Cargoes Involved in Neurodegenerative/Neurodevelopmental Diseases
Karyopherin β2 is a nuclear-import receptor that transports many RNA-binding proteins into the nucleus by recognizing within the cargoes a unique nuclear-localization signal known as the PY-NLS. Several of Kapβ2 cargoes are mutated in neurological diseases. Two such proteins of interest to my …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… Androgen Receptor (AR) is responsible for driving disease progression, therefore therapies often target this signalling axis. Eventually, these treatments fail and the cancer progresses to an aggressive, incurable stage known as castrate-resistant prostate cancer (CRPC), for which very few …
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Axonal Translation and Links to Neuropathies
… regulation of the axonal proteome by local protein synthesis (LPS) plays a critical role in neuronal wiring and axon survival, raising the intriguing possibility that some neurological disorders involve LPS dysfunction. To visualise LPS in situ, I optimised multiple imaging techniques to …
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Advances in understanding protein-lipid interactions through biophysical and bioelectronic approaches
Intrinsically disordered proteins (IDPs) are those that to do not possess a well-defined three dimensional structure. As a result, they show great flexibility when it comes to adopting a suitable conformation based on the target of interest. However, due to the nature of the free energy landscape …
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Modeling of FUS- and C9ORF72-associated cortical neuropathology using patient-specific induced pluripotent stem cells
Amyotrophe Lateralsklerose (ALS) ist eine neurodegenerative Erkrankung, bei welcher speziell erste (kortikospinal) und zweite (spinal) Motorneurone (MN) von Neurodegeneration betroffen sind. Gegenwärtig bleibt ALS eine unheilbare Erkrankung. Der Tod tritt durchschnittlich 2 bis 5 Jahre nach …
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The role of the RNA-binding protein FUS in axonal organisation and disease
The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
… diseases are associated with protein misfolding and amyloid aggregation. The work presented in this thesis involves the use of fluorescence lifetime imaging microscopy (FLIM) and other biophysical techniques to elucidate the molecular mechanisms that underlie different …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
According to the “ribosome heterogeneity hypothesis”, ribosomes are not all identical, and specialized ribosomes, capable of finely tuning translation of selected mRNAs, do exist. Multiple types of ribosomes are defined by several elements, such as their composition, and their association with …
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Atomic force microscopy methods to study protein phase transitions
Proteins occupy many regions of the phase space, with the ability to form dense liquids and gels, such as viscoelastic condensates, and solids, such as disordered oligomers and ordered amyloid fibrils. This rich phase behaviour of polypeptides is necessary for biological function; however it also …