Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Furanone"”.
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Halo Enol Lactones as Enzyme-Activated Irreversible Inhibitors of Alpha-Chymotrypsin: I. The Effect of Lactone Substitution Pattern. Ii. Alpha - Amino-Functionalized Lactones
… The 4-phenyl-5(E)-(iodomethylidene) tetrahydro-2-furanone, the 4-phenyl-5(E)-(iodomethylidene)dihydro-2-furanone, the 4-phenyl-6(E)-(iodomethylidene)tetrahydro-2-pyranone and the 5-phenyl-6(E)-(iodomethylidene)tetrahydro-2-pyranone were prepared using a halolactonization reaction to convert the …
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Novel strategies for the inhibition of biofilm formation on polymer surfaces
… were employed: 3-butyl-5-(bromomethylene)-2(5H)-furanone and the RNA III inhibiting peptide (RIP). These molecules have a big advantage compared to the currently used antimicrobial agents, since they do not kill bacteria, they are unlikely to induce bacterial resistance. 3 Butyl 5 …
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Quroum sensing disruption and the use of short-chain fatty acids and polyhydroxyalkanoates to control luminescent vibriosis
… franciscana) nauplii. Subsequently, halogenated furanones were shown to disrupt quorum sensing in these bacteria by decreasing the DNA-binding activity of the quorum sensing master regulator protein LuxR. Interestingly, the addition of 20 mg l-1 of the furanone to the culture water of gnotobiotic …
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Analysis of Aroma Constituents in Cultivated Strawberries by GC/MS
… volatile compounds, 2,5-dimethyl-4-methoxy-3(2H)-furanone (DMF) and 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DHF) were reported to contribute heavily to strawberry aroma. These two compounds have been found in all wild strawberries studied, but found only in few cultivated varieties. In this work, …
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Chemistry and synthesis of 3(2H)-furanones and 4,5-dihydro analogues: mechanistic investigations and stereochemical control
… of the five-membered oxygen heterocycles – 3(2H)-furanones and their 4, 5-dihydro analogues. Chapter one of the thesis is a review of the relevant chemistry of the compounds: their synthesis and key transformations. In chapter two, new research on 3(2H)-furanones is outlined in two parts. The …
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Synthesis and utilization of guanidine catalysts for applications directed towards the preparation of butenolide and modified amino acid derivatives
… the vinylogous aldol reaction between dicbloro furanone and benzaldehyde. Incorporating chirality into the guanidine catalyst utilizing a (R)-phenylalaninol auxiliary, generating (R)-2-((5Hdibenzo[ d,t] [1,3 ]diazepin-6(7H)-ylidene ) amino )-3 -phenylpropan-l-ol, demonstrated enantioselectivity …
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Strategies for reducing the mutagen content of chlorinated aqueous media
… 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, which can be released into potable waters or from industrial facilities, technologies for monitoring the concentration, reducing the quantity, and inhibiting the formation of this compound were investigated. Adsorption of the chlorinated …
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Identification and quantitation of predominant odorants in roasted chicory
… 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF), 3-hydroxy-2-methyl-4-pyrone (maltol) , (E,E)-2,4-decadienal, and trans-4,5-epoxy-(E)-2-decenal. Rotundone, with its distinctive aromatic woody, peppery and “chicory-like” note was also detected in five different commercial ground …
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Access to modified geiparvarins using Pd(0)-mediated C-C bond forming reactions
… is a natural product which contains both a 3(2H)-furanone and a coumarin moiety in its structure. The aim of this project was to investigate the use of Pd(0)-mediated C–C bondforming reactions to produce structurally modified geiparvarins. Chapter 1 consists of a review of the relevant literature, …
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Intramolecular carbenoid insertion : reactions of [alpha] -diazoketones derived from benzothienyl, pyrolyl and indolyl alkanoic acids with rhodium (II) acetate
… gives 5,5-bis( 1benzothiophen- 2-ylmethyl)-2(5H)-furanone (166) along with the tricycle 159. The chemistry of the pyrrolyl and the indolyl moieties linked to terminal adiazoketone systems was also investigated. The decomposition of I-diazo-(2-pyrrolyl)-2propanone (173) results in the formation of …
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The microbiology of diabetic foot infections: a Ghanaian perspective
… using baicalin hydrate, cinnamaldehyde and 2(5H)–furanone showed considerable inhibition of K. pneumoniae and P. mirabilis biofilm formation but failed to completely inhibit their growth. The combinatorial effects of antibiotics and QS inhibitors/antimicrobial peptides such as polymyxin B and …
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Controlling Biofouling by Surface Engineering and Molecular Inhibition
… of a class of molecules called brominated furanones, which are known to inhibit biofilm formation in E. coli. Chapter 7 reports the synthesis of novel squarate based molecules named squarylated homoserine lactones (SHLs), which are structural mimics of the bacterial autoinducer molecules …
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Coating of Polyvinylchloride for Reduced Cell / Bacterial Adhesion and Antibacterial Properties
… N-vinylpyrrolidone, 3,4-Dichloro-5-hydroxy-2(5H)-furanone derivative and succinimide residue was evaluated with cell adhesion, bacterial adhesion and bacterial viability. Surface adhesion was evaluated with 3T3 mouse fibroblast cells and two bacterial species. Also, antibacterial activity was …
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Reactions of cyclomanganated compounds
… with the cyclomanganated chalcone 54 gave furanone products (e.g. 190 and 191). An oxidative addition and reductive elimination mechanism was proposed to explain this reaction. Among others, the crystal structures of 50, 89 and 130 were determined.
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Biosynthese und Metabolismus von 2,5-Dimethyl-4-hydroxy-3(2H)-furanon in Erdbeeren
… der applizierten Zucker zu den beiden Furanonen DMHF und DMMF gezogen werden. Als mögliche Ausgangsstoffe dienten unterschiedlich markierte D-Glucose und D-Fructose, sowie Desoxyzucker, da diese als direkte Vorläufersubstanzen von DMHF und DMMF diskutiert werden. Isotopenmarkierte …
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Identification of compounds responsible for the characteristic “soy sauce” flavor of traditional Chinese liquor
… trisulfide and 3-hydroxy-4,5-hydroxy-2(5H)-furanone (sotolon). Four sulfur-containing odorants which might provide “savory” top notes to the flavor of MT were identified as 2-methyl-3-furanthiol (MFT), 2-methyl-3-(methyldithio)furan (MFT-MT), 2-furfurylthiol, and bis(2-methyl-3-furyl) …
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Effects of Quorum Quenchers on Aspergillus fumigatus Conidia Aggregation, Adhesion to Surfaces, and Biofilm Formation
… as the effects of microbial quorum quenchers, furanone, farnesol and tyrosol were investigated against A. fumigatus for the first time. Amphotericin B (AMB), a common antifungal agent used against A. fumigatus infection, carries adverse effects against human health. So, triclosan’s antifungal …
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Synthesis and characterization of diphosphine ligand substituted osmium and ruthenium clusters.
… 3,4bis(diphenylphosphino)-5-methoxy-2(5)H-furanone (bmf) at 25 ºC to give the bmf-bridged cluster 1,2-Os3(CO)10(bmf). Heating 1,2-Os3(CO)10(bmf) leads to an equilibrium with the chelating isomer 1,1-Os3(CO)10(bmf). The molecular structure of each isomer has been crystallographically …
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Discovering the Biological Activities of Maltose Derivatives for Controlling Bacterial Multicellular Behaviors
… agents, maltose derivatives and brominated furanones, as modulators of different bacterial multicellular behaviors has been demonstrated. Rhamnolipids secreted by Pseudomonas aeruginosa are biosurfactants that are known to be essential for at least three multicellular behaviors of P. …
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