Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"Functional study"”.
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Functional Study of Hemogen Knockout Mouse Model
… Hemgn knockout mouse model has been generated to study its function in normal and stress hematopoiesis. I confirmed the Hemgn expression in hematopoietic organs including bone marrow and spleen, as well as round spematids in testis. Hemgn is expressed in mouse hematopoietic stem cells and …
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FUNCTIONAL STUDY OF MAMMARY EPITHELIAL CELL ARCHITECTURE
Cell organization confers cellular identity and guides cellular functions. Here, the
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Structural and Functional Study of Multidrug Membrane Transporters
… unknown. In this dissertation, we focus on the study of structures and functions of multidrug membrane transporters, including ATP-binding cassette transporter (BmrA) and Resistance-Nodulation-Cell Division transporter (MexA,B-OprM) in gram-positive and gram-negative bacteria (<em> Bacillus …
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Density Functional Study of Hydrogen in Amorphous Silicon
Our calculations clarify the role of H during electronic defect formation. We calculate the energetics for H to move from a variety of Si-H bonds to the bulk chemical potential. For isolated Si-H bonds (i.e. in micro-cavities without any bond reconstruction) the energetics are not consistent with …
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Morphological and functional study of cerebral aging in rat
… properly stimulated may warrant a considerable functional recovery. Aim of the present research was to verify the plastic potentialities of the aging brain of rats subjected to two kind of exogenous stimuli: A) the replacement of the standard diet with a ketogenic regimen (the change forces the …
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THE PHD FINGER OF SP140: A STRUCTURAL AND FUNCTIONAL STUDY
… thesis we investigated Sp140 PHD finger both at functional and structural level. Structural determination was performed in solution by means of NMR spectroscopy. Analysis of 1H-15N HSQC spectra of Sp140 15N PHD finger wild type and 15N PHD finger P45A mutant revealed peptidyl-prolyl cis trans …
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The Structural and Functional Study of GIT1 Paxillin Binding Domain
<p>The G protein coupled receptor (GPCR)-kinase (GRK) interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of p21-activated kinase (PAK) and PAK-interactive …
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Density Functional Study of NO Decomposition With Cu-Exchanged Zeolites
… and O$\sb2.$ The present work is an attempt to study this phenomenon using a first-principles quantum mechanics-based density functional method. A small cluster model is proposed and used to examine the properties of zeolite-bound Cu ions, and their interactions with various species relevant to …
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Evolutionary and functional study of plant cell wall polysaccharide glucomannan
My PhD thesis focused on the cell wall polysaccharide mannan; I investigated the function, evolution, and mutant phenotypes of its synthase. The main chapter consists of three independent parts. Chapter2 addresses the question, “In which group of evolutionary stages does β-GGM …
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Transcriptional and functional study of Arabidopsis defence response against Pseudomanas syringae.
… ES4326 were chosen as candidates for our study. Arabidopsis T-DNA mutants were ordered and assayed for bacterial growth. Mutants that consistently supported more bacterial growth than wild type controls were selected for further analysis. We also monitored expression profiles of wild-type …
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Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes
… main and unique objective of this study was to identify any common Caucasian sequence variants in UCH-L1’s promoter, and to investigate whether they are associated with neurodegenerative symptoms, and any change in UCH-L1 transcriptional activity.<br/>Seven novel UCH-L1 Single …
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Cloning, Characterization, and Functional Study of Laminin a Chain in Hydra
… a fresh water cnidarian, was used in this study of extracellular matrix (ECM) molecular functions at the genetic level. To clone ECM genes, screening of a hydra cDNA library was accomplished by using a laminin A chain sequence obtained from polymerase chain reaction as a probe. A clone, 1am …
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Functional study of miRNA-mRNA interactions in malaria mosquito An. gambiae
… at miRNA integration. To investigate the functional roles of miRNAs and define context-dependent miRNA-mRNA interactions during the reproductive process, I have applied an innovative experimental approach to study miRNA-mRNA interactome. CLEAR (covalent ligation of endogenous …
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Functional study of the IFITM1 gene related to tumor progression of NF1
"국문요약 i 차례 iv 그림차례 v 표차례 vi Ⅰ. 서론 1 Ⅱ. 재료 및 방법 9 1. Tissue sample 9 2. Primary fibroblast 배양 10 3. 유전자 과발현을 위한 IFITM1 construct 구축 10 4. Total RNA 추출 및 cDNA 합성 12 5. RT-PCR (Reverse Transcription-PCR) 12 6. Western blot analysis 13 7. Ras activation assay 15 8. Cell death assay 15 9. Transfection …
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Functional study of Gap Junctional Intercellular Communication in Human Keratinocyte Cell Line
… compared to those in normal human skin. In this study, spontaneously immortalized non-tumorigenic and a highly diffenrentiating keratinocyte(HaCaT) cell line was used to find substances that can change the GJIC function via fuctional study using scrape-loading dye transfer(SLDT) method. Toxic …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
Breast cancer is one of major public health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… for humans to treat diseases. <br/><br/>In this study, the skin secretions of the Chinese Piebald Odorous Frog (<i>Odorrana schmackeri</i>) and the European Edible Frog (<i>Pelophylax kl. esculentus</i>) were collected using an electrical stimulation method. Afterwards, three novel peptide …
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A functional study of the<em> Phytophthora infestans</em> Avr3a alleles and paralogs
… Avr3a alleles E80M103 and/or K80I103. However, a study of Avr3a diversity in the Toluca Valley, Mexico, has identified additional alleles such as K80I103L139, K80I103H133, E80M103H133 and E80M103G124. Functional studies of these alleles were conducted as part of this thesis, which also include the …
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