Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"Functional genomics"”.
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Functional genomics of developmental disorders
DNA methylation, or the epigenetic modification of primarily cytosine bases within DNA to 5-methylcytosine through the addition of a methyl group, is an epigenetic mark with a variety of biological and cellular roles. Genetic and environmental influences can perturb DNA methylation patterns in …
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Functional genomics of plant compensatory responses
… particular note, there did not appear to be any functional redundancy of other invertases or any of the sucrose synthases. Thus, all invertase isoenzymes seem to be necessary for normal growth, development and reproduction and, most importantly here, for growth and fitness compensation following …
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Multiplexed Crispr Libraries For Cancer Functional Genomics
… has improved the sensitivity and specificity of functional screenings. Despite this advance, there remains a long-standing need to improve functional screenings with smaller and more versatile pooled libraries. Capitalizing on the inherent multiplexing capability of a class 2 CRISPR enzyme …
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Functional genomics of motile commensal intestinal bacteria
… species in microbial communities by metagenomics. In summary, this thesis used a functional genomics approach to describe flagellum-mediated motility in selected Gram-positive commensal bacteria. The regulation of flagellum biosynthesis in these species, and the consequences of flagella …
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Functional Genomics of Nitrogen Use in Maize
Maize cultivars vary widely in their ability to translate nitrogen (N) accumulated during growth into grain yield. Little is known about what determines this capacity, termed N-utilization efficiency (NUtE) in agronomic studies. However, recent investigations have implicated the variation in how …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
Adult skeletal muscles can regenerate after injury due to the presence of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to …
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Functional genomics of a non-toxic Alexandrium lusitanicum culture
Paralytic shellfish poisoning (PSP) is a human intoxication associated with the consumption of shellfish contaminated with a family of neurotoxins called saxitoxins. Many species in the dinoflagellate genus Alexandrium have been shown to produce these toxins. Here I report the first case of a …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
… in both the Hh and the Wnt pathways, and that functional genomics based approaches to dissecting cell-fate determination pathways may support the development of targeted therapeutic strategies.
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Population genetic frameworks and functional genomics of Mycobacterium bovis
… identified ~900 SNPs between them. Comparative genomics with other members of the Mycobacterium Tuberculosis Complex revealed a high percentage of sequence similarity between the strains. Thus, this study provides new evidence in favor of low genetic variability in this organism, suggesting …
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Functional Genomics and physiology of growth initiation in Salmonella
… four minutes of inoculation into fresh medium. Functional categories of genes that were significantly up-regulated included those encoding systems involved with metal ion uptake, stress resistance, phosphate uptake, ribosome synthesis and cellular metabolism. Genes in the OxyR regulon were …
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High-dimensional covariance estimation with applications to functional genomics
Covariance matrix estimation plays a central role in statistical analyses. In molecular biology, for instance, covariance estimation facilitates the identification of dependence structures between molecular variables that shed light on the underlying biological processes. However, covariance …
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Machine learning models for functional genomics and therapeutic design
… to develop advanced machine learning models for functional genomics and therapeutics design, two areas with ample data deposited in public databases and tremendous clinical implications. The shared theme of these models is to learn how the composition of a biological sequence encodes a functional …
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Functional genomics of a non-toxic Alexandrium lusitanicum culture
Paralytic shellfish poisoning (PSP) is a human intoxication associated with the consumption of shellfish contaminated with a family of neurotoxins called saxitoxins. Many species in the dinoflagellate genus Alexandrium have been shown to produce these toxins. Here I report the first case of a …
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A recombineering pipeline for functional genomics applied to Caenorhabditis elegans
… They also present the challenge to generate functional information for thousands of previously uncharacterized genes. Protein tagging with fluorescent or affinity tags provides a generic way to describe protein expression and localization patterns and protein-protein interactions. The genome …
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Functional genomics of nodulins in the model legume Lotus japonicus
… involved in SNF, validate their expression and functionally characterise them. An existing 5.6K cDNA array (Colebatch et al., 2004) was extended to produce the 9.6K LjNEST array, while a second array, the 11.6K LjKDRI array, was also produced. Furthermore, the protocol for array hybridisation …
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A Functional Genomics Approach to the Plant Soluble Pyrophosphatase Family
Although the activities of soluble pyrophosphatases were shown to be essential for a number of prokaryotes and eukaryotes, plants were assumed to lack cytoplasmic soluble pyrophosphatase activity and vacuolar membrane bound proton-pumping pyrophosphatase was accepted as the only enzyme responsible …
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Principled Methods and Models for Deep Learning Based Functional Genomics
Many advances in functional genomics and in biology more broadly can be attributed to the rise of massively parallel sequencing technology and its derivatives. As the volume of sequencing and other high-throughput experimental data increases exponentially, so does the need for computational methods …
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Transformation of a Transposon Construct into Tomato for Functional Genomics Studies
Tomato (Solanum lycopersicum) is a member of the Solanaceae family. In this research project tomato, more specifically the M82 cultivar was chosen as a model plant for Agrobacterium-mediated gene transfer by cotyledon inoculation. Our objective was to transform tomato with a T-DNA construct bearing …
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Functional genomics through metabolite profiling and gene expression analysis in Arabidopsis thaliana
… genome project, and to employ state-of-the-art functional genomics techniques to assign function to each gene. This will be achieved through a complete understanding of what all cellular components do, and how they interact with one another to produce a phenotype. Among the proteins encoded by …
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