Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"Functional Redundancy"”.
-
Carbon cycling and functional redundancy in closed microbial ecosystems
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
-
Genetic studies on functional redundancy between profilin1 and profilin2 im mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior
Genetic studies on functional redundancy between profilin1 and profilin2 in mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior Profilin1 and profilin2 are two actin-binding proteins. Biochemically, proflin1 and profilin2 are similar in respect to their …
-
Characterization of the expression patterns of <i>CELLULOSE SYNTHASE-LIKE A (CSLA)</i> genes in <i>arabidopsis thaliana</i> using reporter promoter-fusions and immunolocalization
… and we hypothesize that there is some degree of functional redundancy among these genes. A detailed investigation of transgenic Arabidopsis plants harboring promoter-<i>GUS</i> fusions at various phases of growth and development was conducted to examine the expression patterns of all nine …
-
YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
… null tumors. Our data suggest that this reflects functional redundancy between yap and its paralog, taz, either of which can efficiently drive UM. Furthermore, we show that the tumorigenic effects of YAP and TAZ are TEAD-dependent. To determine the human relevance, multiple YAP or TAZ-deficient …
-
Physiological response of Rhizobium leguminosarum during bacteroid development
… phenotypes but more importantly, highlighted functional redundancy between certain gene products. A clear example of functional redundancy was seen between the Mn2+ transporters SitABCD and MntH. Single mutations in sitA or mntH did not cause a symbiotic phenotype whereas the double mutant …
-
Characterization of SCF Ubiquitin-Ligase Subunits in Arabidopsis
… its members, raises the prospect of significant functional redundancy among select paralogs. We have assessed the potential for functional redundancy within the ASK gene family by analyzing an expanded set of criteria that define redundancy with higher resolution. The criteria used include …
-
Role of the atypical Notch ligand Dlk2, and it’s relationship with Dlk1 in mammalian neurogenesis
… embryogenesis. I hypothesise that there is functional redundancy between the two genes during neurogenesis. In particular, I propose that Dlk2 rescues a potential embryonic neurogenesis defect in Dlk1 mutants. Furthermore, I propose that Dlk2 is unable to rescue the Dlk1 mutant neurogenic …
-
Factors of ecological resilience in global temperate estuaries : a systematic review
… shorter temporal scales than natural processes. Functional redundancy, habitat complexity, and healthy food webs were identified as indicators of resilience at multiple scales. My research identifies tools available for measuring resilience to guide localized management of external stressors in …
-
Evaluating the role of Exo1p in chromosome breaks at FS2 in Saccharomyces cerevisiae
… in cells lacking Exo1p. We conclude that the functional redundancy between Exo1p and other enzymes is sufficient to compensate for the loss of Exo1p function in the cell.</p>
-
Characterization of the Enhancer and Promoter Elements of the Human TAF(II)55 Gene
… Mediator complexes allows us to address the functional redundancy and/or transcriptional synergy among three general cofactors (TAFIIs, Mediator and PC4) commonly implicated in activator-dependent transcription from both TATA-containing and TATA-less promoters.
-
T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… exhibited transcriptional similarity, termed functional redundancy. This similarity was repair-associated, and a defining gene of the transcriptional profile was amphiregulin (AREG). When quantified, T cells from subjects with a viral lower respiratory tract infection (LRTI) that did not …
-
Nitrification inhibitors have minimal impact on microbial and Collembola communities in Danish arable soil
… processes, highlighting the resilience and functional redundancy of these communities. Despite the limited direct impact of NIs, high concentrations of organic matter correlated significantly with microbial community structures under high NI conditions, underscoring the buffering role of …
-
Determining the differential roles of the dock family of GEFs in drosophila development
… guidance. Overlapping expression patterns and functional redundancy among the eleven vertebrate Dock family members, which are subdivided into four families (Dock-A, B, C, and D), complicate genetic analysis. Drosophila melanogaster is an excellent genetic model organism to understand Dock …
-
Incomplete paralog compensation and splicing regulation by TRA2A and TRA2B in cancer
… without compromising viability. In cancer, this functional redundancy provides resilience against genomic instability but also creates therapeutic opportunities through synthetic lethality, where co-disruption of both paralogs results in cell death. This dissertation explores the functional …
-
Understanding microbial communities through horizontal gene transfer
… indicative of substantial cross-feeding and functional redundancy in the microbial community. Utilising the method of inoculum dilution to manipulate diversity and a previously established design to trace community-level horizontal gene transfer (HGT) events, I proceeded to experimentally …
-
Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… proteins, overlapping tissue expression and functional redundancy in cells. Thus, we turned to the Drosophila model system where a single gene, CG11063 or djub, exists. The generation and analysis of Drosophila containing djub mutant loss-of-function alleles or depleted of dJub by RNAi …
-
The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the formation of most human cancers. pRB is a member of the pocket protein family, which includes p107 and p130. The pocket proteins have some …
-
Characterization of the class A synthetic Multivulva genes, which act in C. elegans vulval development
… vulval induction and of the nature of their functional redundancy with Rb, we have cloned and characterized additional members of this pathway. We find that the class A synMuv gene lin-56 encodes a novel nuclear protein that shares an atypical CCCH motif with the class A synMuv protein …
-
Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis
… the cells. In order to understand the degree of functional redundancy shared by homologous members of this family, a genetic model of Oct-i was created using gene targeting. The targeting strategy replaced exon 3, which encodes part of the transactivation domain, with a loxP-flanked neomycin …
-
The Functional Synergy Between Yeast Dynamin and Key Membrane Recycling Factors
… mutants lacking both VPS1 and its presumable functional partners. First, we checked the potential growth defects of double mutants and found that double mutants exhibited similar growth rates as single mutant cells. Whether the inactivation of VPS1 and the recycling genes together could result …
Page 1 of 4