Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Functional Interactions"”.
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… between the peptide structure and its functional interactions. Here, we report the analysis of two groups of synthetic peptides designed for two applications – broad bactericidal action and inhibition of protein-protein interactions in human cells. Novel amphiphilic peptides designed …
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New evidence of functional interactions within the hand motor system
… of information between anatomically distant, but functionally interconnected, cerebral areas. In light of the most recent neuroscientific advance in the field of motor control, we investigated the specific role of the cerebral areas of the motor system and their functional interactions during the …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
<p>The Par-1 family of serine/threonine protein kinases functions to regulate cell polarity and is conserved from yeast to humans. Par-1 is encoded by one of six Par: partitioning-defective) genes: Par-1-6) originally identified in a genetic screen conducted in Caenorhabditis elegans: C. elegans). …
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Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway
Thirty years of research have implicated ubiquitin (Ub) signaling in nearly every aspect of eukaryotic cell biology. What appears to be a simple signaling molecule in fact has the ability to encode countless cellular fates that include proteasomal degradation, cell cycle control, and DNA damage …
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REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3
The neural crest (NC) is a transient embryonic cell population that diversifes into a wide variety of cell types including glia and neurons of the peripheral neurvous system, pigment cells and elements of the craniofacial skeleton. However, the mechanisms regulating the process of neural crest cell …
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Development and application of methods for analysis of fungal glycosphingolipid structure and functional interactions
… use in assaying protein-carbohydrate binding interactions was carried out. The potential utility of this methodology for designing microarrays that incorporate both mammalian and fungal GSLs for serodiagnosis is discussed.</p>
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Functional Interactions Among Thyrotropin-Releasing Hormone (Trh), Prolactin (Prl) and Dopamine (Da) in the Brain
The goals of my thesis research centered in the study of the mechanisms that regulate the in vitro release of thyrotropin-releasing hormone (TRH) from the mediobasal hypothalamus (MBH) and in the actions of prolactin (PRL) on the activity of dopaminergic neurons in the striatum and the MBH. In the …
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An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
A better understanding of structural and functional interactions between cardiac and non-cardiac cells is essential to better address the sequelae of cardiac disease and improve the potential cellular implantation therapies. First, an in vitro model was established to investigate the probability …
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Molecular Mechanisms of DNA Protection by Tardigrade Damage Suppressor Protein (Dsup): Structural Adaptation and Functional Interactions
… charged residues, mediates strong electrostatic interactions with DNA, while the helical region stabilizes the complex through structural adaptation. Experimental results confirm that X-ray irradiation did not compromise the integrity or cause additional oxidative damage to free DNA in the …
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p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… protein, specifically, the crosstalk (or functional interactions) with other transcription factors, namely, the estrogen receptors, and the modeling in reconstituted assays of the interaction of p53 with positive and negative cofactors (e.g. MDM4 and 53BP1) and the impact of small …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
L'aneuploidia è una caratteristica intrinseca delle cellule tumorali e della trasformazione cellulare. Questa tesi di dottorato indaga i meccanismi molecolari alla base dell'instabilità cromosomica e dell'espressione genica nel cancro, concentrandosi sul carcinoma colorettale e …
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Cell-type specific cholinergic modulation of the cortex
… circuit elements involved and define how their interactions contribute to cortical network dynamics. In this thesis, I present evidence showing how specific neuronal and glial cell types can be differentially modulated by acetylcholine (Ach), resulting in dynamic functional interactions during …
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Functional analysis of syp1, a novel substrate of the serine/threonine kinase prk1
… In this study, Syp1p has been found to have functional interactions with the actin cytoskeleton. Syp1p is a new substrate of Prk1p, a kinase that regulates actin dynamics. Syp1p colocalizes with actin cytoskeleton whose integrity is required for the polarized localization of Syp1p. Syp1p can …
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Inherent discipline required in large system change
… devices, which results in complex functional interactions throughout the electrical system. This trend often drives a large system change that modifies the engineering roles of the component level engineer and also creates a need for an evolution to a vehicle level systems …
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NMR investigations of blood coagulation: Conformational changes of membrane bilayers and proteins in blood coagulation
… and their associated membrane proteins. The interactions of these biological molecules lead to perturbations in their structure and dynamics. Understanding the variations in the constitution of these molecules as the result of functional interactions will provide insights into various …
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Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
… affinity of Varp. Additionally, as some reported functional interactions have not yet been localised to any particular region of Varp, the as- yet-unstudied N-terminal domain of Varp (residues 1-136) was investigated using a Yeast-2-Hybrid screening approach, to try to identify any interaction …
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Neuronaalisten kolinergisten nikotiinireseptorien positiivinen ja negatiivinen allosteerinen modulaatio
… part of the pro gradu was to study in vitro interactions of nicotine and three different opioids, codeine, oxycodone and tramadol in SH-SY5Y cells. SH-SY5Y cells express endogenously α3* and α7-nAChRs. Binding assays were performed with radioactive ligand [3H]-epibatidine. Functional …
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P120-Catenin Regulates Rest and Corest, and Modulates Mouse Embryonic Stem Cell Differentiation
… required as a consequence of its biochemical and functional interactions with cadherins, small-GTPases and transcriptional regulators. We report here that p120-catenin binds to and negatively regulates REST and CoREST, that others have indicated form a repressive complex having diverse key roles …
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