Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Functional Genomic"”.
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… patients. To this end, we harnessed the power of functional genomic screening to identify both host and vaccinia virus (VV) genes that could be manipulated to enhance the efficacy of VV. We hypothesized that one approach to enhancing the efficacy of VV was to increase its ability to spread in …
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Network analyses for functional genomic screens in cancer
Gene interference screens are a widely adopted and popular tool for uncovering gene function but imperfections in the technology limit the power of these investigations. There are many completed and on-going RNAi investigations across a multitude of biological systems because these experiments are …
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Functional genomic study of the parotoid secretion from Bufo gargarizans
The parotoid secretion from Bufo gargarizans has been used as a traditional Chinese medicine for 2000 years in the treatment of inflammation, swelling and carbuncles. Recent studies have been focused on the small molecules, the bufadienolides and biogenic amines, the main medicinal parts in its …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
… amphibian skin secretions. In vitro and ex vivo functionalevaluations were subsequently employed which not only bring us a better understanding on the diversity of natural sourced bioactive peptides but also emphasized the research value for characterizing their in depth mechanisms
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Functional genomic studies of regeneration in the planarian Schmidtea mediterranea
… de novo? We brought the power of comparative genomics to bear on a portion of this broad question, and a cohort of genes was found that appeared to only be conserved in organisms capable of somatic tissue replacement as adults. Those genes were characterized in silico, then whole-mount in situ …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
… In this thesis, we present the development of functional genomic and synthetic biology tools to address this challenge. We first applied optical pooled screening to quantify cell-cell interactions in mixed cultures with primary neurons and reveal functional interaction partners of synaptogenic …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… elements played a significant role in creating genomic diversity and phenotypic variability among strains of H. somni. Functional characterization of H. somni luxS in the genomic context revealed that the gene encodes S-ribosylhomocysteinase that can complement biosynthesis of AI-2 quorum …
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Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
… elucidating the activated PPAR-gamma controlled genomic program responsible for these observed phenotypes, functional genomic analysis was performed using a two-class longitudinal microarray data set in the presence and absence of RS5444. Differential expression of genes was obtained using an …
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CRISPRI-based high-throughput functional genomic approaches for use in mycobacteria
… significant efforts have been made to complete functional annotation of the genome. However, these efforts have generally been performed on a single-gene basis, ensuring slow progress and leaving large portions of the genome unannotated. High-throughput approaches to understanding the functional …
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CRISPR/CASTE: Functional Genomic Studies of the Major Evolutionary Innovations of Ants
<p>Ants are social organisms that live in groups and depend intimately on their nestmates for growth and survival. Ants have evolved a number of highly sophisticated, social phenotypes that allow them to form coherent colonies. This thesis explores two particularly derived features of ant biology: …
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Functional genomic analysis of cell cycle progression in human tissue culture cells
… a major technical advance for large-scale functional genomic studies in mammalian tissue culture cells and provides novel insights into various aspects of cell cycle progression. (Die Druckexemplare enthalten jeweils eine CD-ROM als Anlagenteil: 217 MB: Movies, Rohdaten - Nutzung: Referat …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
Aspergillus fumigatus is an opportunistic pathogen which can cause severe disease in immunocompromised patients. A. fumigatus produces metabolites, through a non-ribosomal peptide synthesis mechanism, including iron-chelating molecules known as siderophores and other unusual compounds such as …
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Improving Statistical Learning within Functional Genomic Experiments by means of Feature Selection
… including microarray data as well as other functional genomic experiments. Microarray technology allow measuring tens of thousands of genes (features) simultaneously. However, the expressions of these genes are usually observed in a small number, tens to few hundreds, of tissue samples …
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Functional Genomic and Image-Based Screening Approaches for Probing Host-Pathogen Interactions
… this thesis, I describe approaches to leverage functional genomics and image-based screening to perturb and profile host-pathogen interactions, including responses to two RNA viruses, Sendai virus and Ebola virus. These provide case studies highlighting the utility of high-content image-based …
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Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota
… in vivo. I have used comparative and functional genomics, proteomics and biochemical assays to identify the ways they marshal their genomic resources to adapt to life together in the distal gut. I first annotated the complete genome sequences of two human gut Bacteroidetes …
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Mutual information relevance networks : functional genomic networks built from pair-wise entropy measurements
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
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Functional Genomic Approaches to Study Cell Polarity Regulation by G1 Cyclins in Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1-, Cln2-Cdc28 and Pcl1-, Pcl2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, like most genes in S. …
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