Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Functional Enrichment"”.
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Integration of Functional Enrichment Analysis Techniques
Η λειτουργική ανάλυση εμπλουτισμού αποτελεί βασικό εργαλείο ερμηνείας ομικών πειραμάτων. Ωστόσο, τα αποτελέσματα της επηρεάζονται σημαντικά από μια σειρά αναλυτικών επιλογών που σπάνια τεκμηριώνονται: ποιο εργαλείο χρησιμοποιείται, πώς ορίζεται το σύνολο αναφοράς, ποιες βάσεις γνώσης ερωτώνται, …
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Bridging Methodological Gaps in Network-Based Systems Biology
… methodological gaps in systems biology. i. Functional enrichment methods provide a summary of biological functions that are overrepresented in an interesting collection of genes (e.g., highly differentially expressed genes between a diseased cell and a healthy cell). Standard functional …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… of classical, SCC-like, and normal-like BCCs. Functional enrichment and pathway analyses revealed the molecular characteristics of each subtype. The classical BCC showed the enriched expression and transcription signature with the activation of Wnt and Hedgehog signaling pathways, which were …
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Identifying Evolutionarily Conserved Protein Interaction Networks
… many conserved networks with a high degree of functional enrichment. Using our method, we find many conserved protein interaction networks involved in functions such as DNA replication, protein folding, response to heat, protein serine/threonine phosphatase activity, kinase activity, and ATPase …
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Identifying the Role of Transcription Factor RFX3 in 9PDeletion Syndrome
… Differential Gene Expression analysis, and Functional Enrichment analysis. The findings indicate that RFX3 plays a significant role but is not the sole driver of the neuronal phenotypes. SMARCA2, a gene linked to intellectual disability and part of the SWI/SNF complex, was identified as a …
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Predicting Genetic Interactions Using Functional Interaction Networks
… foundation for coessentiality networks which are functional maps derived from correlated fitness profiles. Yet, existing coessentiality networks are often limited by static representations, lack of contextual resolution, and difficulty capturing context-dependent or multifunctional gene roles. …
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Identification of novel transcripts in hepatocellular carcinoma using RNA-seq
… has been studied, however, prediction of their functional roles in cancers are not studied thoroughly. Here, I constructed new pipeline to identify putative novel transcripts which might play functional roles in hepatocellular carcinoma (HCC) using reference based assembly method, which revealed …
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The transcriptome response of leaves of the resurrection plant, Xerophyta humilis to desiccation
… of water loss in the leaves of X. humilis. Functional enrichment analysis showed that genes that were down-regulated during desiccation were over-represented with genes involved in photosynthesis, cellular developmental processes, as well as transcription regulator activity. Three distinct …
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Study of proteins after recovery from bacterial infection
… gain insights through differential detection and enrichment analysis. Detection relied on tandem mass spectrometry proteomics. The database search software PEAKS was used to detect peptides and proteins in the treated and control samples. Differential detection was performed using SAS procedures …
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The effect of age on human monocyte epigenetics and function
… analysis, differential expression analysis and functional enrichment analysis were used to identify which genes and pathways exhibit changes with age, be it in their methylation level or their transcription. It was determined that differentially methylated regions often mapped to genes involved …
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A high-resolution study of the chromatin environment around regulatory elements
… for that region, a state that carries functional significance. This work seeks to better understand the importance of not just presence, but also distribution of modifications within regulatory regions. One approach aimed at improving our understanding is to cluster regulatory regions …
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Towards Understanding the Genetic Basis of Virulence in Pseudomonas aeruginosa
… these, 280 were genes that do not currently have functional annotations. Functional enrichment analysis of genes highlighted the importance of amino acid biosynthesis and metabolism, nucleotide biosynthesis and metabolism, and biogenesis of motility related structures. This study has laid the …
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The role of citrate in plant-pathogen interactions
… transcriptional reprogramming. In this study, functional enrichment analysis revealed statistically significant enrichment for gene ontology terms associated with defence in both citrate up-regulated and down-regulated gene sets. Furthermore this project demonstrated that exogenous citrate can …
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Spatial Transcriptomics Analysis Reveals Transcriptomic and Cellular Topology Associations in Breast and Prostate Cancers
… with ITFs and we can pursue this using functional enrichment analysis. Moreover, we also find the similarity between gene clusters and some image features clusters using the ranking of correlation coefficient in order to identify, compare and contrast the TAGs across breast and prostate …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… These DEGs were analyzed using g:Profiler2 for functional enrichment. Selected genes from enriched metabolic and immune pathways were then validated by RT-qPCR following treatment with DMSO, DAPT, or the more specific Notch inhibitor IMR-1A. Results revealed that Notch inhibition modulates …
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Identification of genetic and epigenetic alterations in workers exposed to benzene [Identificazione di alterazioni genetiche ed epigenetiche in lavoratori esposti a benzene]
… loro rilevanza come biomarcatori. Le analisi di functional enrichment e network interaction hanno rivelato un significativo ruolo per questi geni nei percorsi di risposta metabolica e immunitaria, con CRK, CXCR6 e NFKB1 ampiamente coinvolti nel pathway di segnalazione delle chemiochine, …
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Bioinformatics characterization of the molecular pathways impacted by immune challenges in the amygdala
… spliced between MIA and control pigs within sex. Functional enrichment analysis provided insight into affected pathways, while protein-protein interaction networks identified non-canonical relationships impacted by MIA. Additionally, complementary analyses, such as transcription factor enrichment …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… in AD brains with concurrent infection. Functional enrichment of validated miR-375-3p targets revealed associations with vascular regulation, and antiviral response pathways, suggesting a role in maintaining blood–brain barrier integrity under inflammatory stress. Integration of miRNA …
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Inference of Gene Regulatory Networks with integration of prior knowledge
… prior knowledge. Using real lung cancer data, functional enrichment analysis and literature validation confirmed the biological plausibility of the networks inferred by FLAP. Different sources of prior knowledge impacted the results, with GIANT providing the most biologically relevant networks, …
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THE HCMV INTERACTOME: A QUANTITATIVE ANALYSIS OF HUMAN CYTOMEGALOVIRUS-HOST PROTEIN INTERACTIONS
… not yet clear how many non-canonical ORFs encode functional polypeptides. Recent studies have provided an extensive overview on the modulation of gene expression as well as the spatio-temporal dynamics of viral and host proteins during HCMV infection. However, characterisation of specific …
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