Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Functional Deficiency"”.
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… in primary colorectal tumours. To determine the functional consequences of these novel cancer-associated PTEN mutations, the WT PTEN and the series of PTEN mutants (K62R, Y65C, K125E, K125X, E150Q, D153N, D153Y, N323K and the C124S and G129E controls) were transiently transfected into: (A) PTEN …
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Influence of retinal states on the development and maintenance of retinofugal projections
… retina, not downstream anomalies, explains this functional deficiency. These observations suggest that changes to eye-specific segregation are limited once projections are established, regardless of retinal activity or remodeling. These observations bode well for future retina-based treatments of …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… selectively induced by IL-12. Furthermore, the functionally identified effector memory CTL population expressed higher levels of MAP3K8 mRNA ex vivo compared to the naïve/central memory CTL population. MAP3K8 or Tpl2 has been shown to play an important role in activating the MAP kinase pathways …
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Machine learning and data analytics for liver disease modeling
… to date and identified profound dysbiosis and a functional deficiency in microbial bile acid deconjugation. By incorporating these microbiome-derived functional parameters into the REMEDI framework, we created an entero-augmented version that captures host–microbiome interactions and demonstrates …
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Role of Stat3 In Human Nk Cell Functions
… pharmacological and genetic models of STAT3 deficiency to study the role of STAT3 in human NK cell proliferation. Treatment with STAT3 inhibitor S3I-201 reduced expansion of human NK cells stimulated with mbIL21 and membrane bound IL-15 (mbIL15). mbIL21 and mbIL15 induced expansion was also …