Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Function Structure"”.
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Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties
Plant aromatic amino acid decarboxylases (AAADs) are a group of economically important enzymes categorically joined through their pyridoxal 5'-phosphate (PLP) dependence and sequence homology. Extensive evolutionary divergence of this enzyme family has resulted in a selection of enzymes with …
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Systematic functional and object-oriented product design frameworks
… of mechatronic products. Three innovative functional and object-oriented integrated design frameworks and one virtual prototyping application, which leverages on these three design frameworks, have been developed for co-design of mechatronic products. The three frameworks are: I) …
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Product family architecture modularity using function and variety heuristics
This thesis examines the market and functional aspects of developing a product portfolio architecture. Product use based market analysis of customer needs and product features is performed to determine the set of portfolio target values. The variation in these target values among and within …
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Extracellular Vesicles to Evaluate the Effects of Mesenchymal Stromal Cells in the Premature Lung
… features of experimental BPD, such as lung function, structure, and inflammation. The HULC-1 trial assessed the safety of MSCs for BPD. Since MSC mechanisms in the premature lung remain unclear, we hypothesized that extracellular vesicles (EVs) might reflect MSC effects. We analyzed EVs from …
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Generative Diffusion Models Towards De Novo Protein Design
… design aims to generate proteins with desired functions by rationally engineering novel protein structures and sequences. The structure requires modeling continuous 3D coordinates of atoms with rigid biochemical constraints of the polymer chain while the sequence is a series of discrete amino …
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Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base
… size and complexity but also its diversity of functions. It is essential for many mitotic and interphase transport processes and its misregulation or malfunction results in devastating neurological disorders. Over 20 years of research in the field has identified many recruitment and regulatory …
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Building a rational model for the identification of allosteric sites
Allostery is the regulation of protein function, structure and/or flexibility that is induced by the binding of a ligand at a site distinct from the orthosteric site.1, 2 Interaction of a small molecule with these sites can bring greater selectivity as they are not conserved within a family and …
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Analogy matching with function, flow and performance
… generation by specifying a set of critical functions and desired design performance improvements. DAPPS uses performance parameter metrics to compare user inputs to potential analogical sources, thus stimulating analogical reasoning and innovative designs. We showcase the validation aspect …
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On the Design of Instream Structures in the Mid-Atlantic United States: An Investigation of the Design, Project, and Watershed Factors that Affect Structure Success
Instream structures are used to reinforce channel margins, redirect flows, and create habitat, but there is little consensus about their design or whether they function as intended. In this study, 536 instream structures in the state of Maryland were assessed to determine the effect of structure-, …
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The Expression and Characterization of Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Tobacco
… in heterologous systems, the exact protein function/structure relationship is unknown. Expression of CFTR in E. coli is lethal and mammalian culture systems are expensive and low yielding. However, successful bioproduction of many complex human proteins has been shown in transgenic plants. …
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The role of Walsh structure and ordinal linkage in the optimisation of pseudo-Boolean functions under monotonicity invariance.
… on implicit or explicit assumptions about the structure of the black-box fitness function they optimise. A review of the literature shows that understanding of structure and linkage is helpful to the design and analysis of heuristics. The aim of this thesis is to investigate the role that …
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Transborder Economic Development: A Collaborative Partnership in the San Diego-Tijuana Region
… methodology is applied to explain the role, function, structure, decision making processes and collaborative leadership relationships of the BPCC. The study also addresses the perceived need by some to create sustainable economic development strategies for the region and the necessity to …
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Understanding travel mode choice: A new approach for city scale simulation
… ML classifier is used to inform the utility function structure in a utility-based choice model, is then explored. The results identify three key findings. Firstly, the Gradient Boosting Decision Trees (GBDT) model is the highest performing classifier for this task. Secondly, the relative …
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Understanding corporate social investment practice in South Africa
… gap by providing an exploratory analysis of the structure and evolution of CSI practice in South Africa. The motivation behind this research is to use the research to optimise the social impact that CSI participation can provide, as well as integrating corporate funding into the broader approach …
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A local model network approach to nonlinear modelling
… framework for the integration of different model structures and learning algorithms.A major difficulty with Local Model Nets is the optimisation of the model structure. A novel Multi-Resolution Constructive (MRC) structure identification algorithm for local model networksis developed. The …
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Analyzing the proliferation resistance of advanced nuclear fuel cycles : in search of an assessment methodology for use in fuel cycle simulations
… fuel cycle simulations. Method assumptions and structure are explained, and reference technology cases are presented to test the model. Eleven metrics are presented to evaluate the proliferation resistance of once-through, COmbined Non-Fertile and Uranium (CONFU), Mixed-Oxide (MOX), and Advanced …
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Synthesis and testing of novel polypeptides for biological applications
… that assemble into complex, highly ordered structures. In particular, proteins and peptides derived from the 20 naturally occurring amino acids are sequenced macromolecules that can fold into secondary and tertiary structures and can self assemble into quaternary structures. Through weak …
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